PMID- 28575528
OWN - NLM
STAT- MEDLINE
DCOM- 20181105
LR  - 20190113
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Print)
IS  - 0586-7614 (Linking)
VI  - 44
IP  - 1
DP  - 2018 Jan 13
TI  - Increased Striatal and Reduced Prefrontal Cerebral Blood Flow in Clinical High 
      Risk for Psychosis.
PG  - 182-192
LID - 10.1093/schbul/sbx070 [doi]
AB  - Increased striatal dopaminergic activity and decreased prefrontal functioning 
      have been reported in individuals at clinical high risk (CHR) for psychosis. 
      Abnormal metabolic rate might affect resting-state cerebral blood flow (rCBF) in 
      the respective regions. Here, we examined if striatal and prefrontal rCBF differ 
      between patients with CHR, first-episode psychosis (FEP), chronic 
      schizophrenia-spectrum disorder (SZ) and controls. Two cohorts with a total of 
      122 participants were included and analyzed separately: 32 patients with SZ and 
      31 healthy controls (HC) from the University Hospital of Psychiatry, and 59 
      patients from the Bern Early Recognition and Intervention Center (29 with CHR, 12 
      with FEP, and 18 clinical controls [CC]). Ultra-high risk criteria were assessed 
      with the Structured Interview for Psychosis-Risk Syndromes, basic symptom 
      criteria with the Schizophrenia Proneness Instrument. rCBF was measured with 
      pseudo-continuous arterial spin labeling 3T-Magnetic Resonance Imaging. Striatal 
      rCBF was significantly increased and prefrontal rCBF significantly decreased in 
      the SZ group compared to HC group and in the CHR and FEP groups compared to CC 
      group. Striatal rCBF correlated significantly with positive symptom scores in SZ 
      and CHR. An inverse correlation between striatal and frontal rCBF was found in 
      controls (HC, CC), but not in patient groups (SZ, FEP, CHR). This is the first 
      study to demonstrate increased neuronal activity within the striatum, but reduced 
      prefrontal activity in patients with CHR, FEP, and SZ compared to the respective 
      controls. Our results indicate that alterations in striatal and prefrontal rCBF 
      are reflecting metabolic abnormalities preceding the onset of frank psychosis.
CI  - (c) The Author(s) 2017. Published by Oxford University Press on behalf of the 
      Maryland Psychiatric Research Center. All rights reserved. For permissions, 
      please email: journals.permissions@oup.com.
FAU - Kindler, Jochen
AU  - Kindler J
AD  - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, 
      University of Bern, Bern, Switzerland.
FAU - Schultze-Lutter, Frauke
AU  - Schultze-Lutter F
AD  - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, 
      University of Bern, Bern, Switzerland.
FAU - Hauf, Martinus
AU  - Hauf M
AD  - Support Center for Advanced Neuroimaging (SCAN), Institute for Diagnostic and 
      Interventional Neuroradiology, University of Bern, Bern, Switzerland.
FAU - Dierks, Thomas
AU  - Dierks T
AD  - Translational Research Center, University Hospital of Psychiatry, University of 
      Bern, Bern, Switzerland.
FAU - Federspiel, Andrea
AU  - Federspiel A
AD  - Translational Research Center, University Hospital of Psychiatry, University of 
      Bern, Bern, Switzerland.
FAU - Walther, Sebastian
AU  - Walther S
AD  - Translational Research Center, University Hospital of Psychiatry, University of 
      Bern, Bern, Switzerland.
FAU - Schimmelmann, Benno G
AU  - Schimmelmann BG
AD  - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, 
      University of Bern, Bern, Switzerland.
AD  - University Hospital of Child and Adolescent Psychiatry, University Hospital 
      Hamburg Eppendorf, Hamburg, Germany.
FAU - Hubl, Daniela
AU  - Hubl D
AD  - Translational Research Center, University Hospital of Psychiatry, University of 
      Bern, Bern, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cerebrovascular Circulation/*physiology
MH  - *Corpus Striatum/blood supply/diagnostic imaging/physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - *Prefrontal Cortex/blood supply/diagnostic imaging/physiopathology
MH  - Psychotic Disorders/diagnostic imaging/*physiopathology
MH  - Risk
MH  - Schizophrenia/diagnostic imaging/*physiopathology
MH  - Young Adult
PMC - PMC5768043
OTO - NOTNLM
OT  - arterial spin labeling
OT  - cerebral blood flow
OT  - clinical high risk for psychosis
OT  - first-episode psychosis
OT  - prefrontal cortex
OT  - schizophrenia
OT  - striatum
EDAT- 2017/06/03 06:00
MHDA- 2018/11/06 06:00
PMCR- 2019/01/13
CRDT- 2017/06/03 06:00
PHST- 2017/06/03 06:00 [pubmed]
PHST- 2018/11/06 06:00 [medline]
PHST- 2017/06/03 06:00 [entrez]
PHST- 2019/01/13 00:00 [pmc-release]
AID - 3858245 [pii]
AID - sbx070 [pii]
AID - 10.1093/schbul/sbx070 [doi]
PST - ppublish
SO  - Schizophr Bull. 2018 Jan 13;44(1):182-192. doi: 10.1093/schbul/sbx070.