PMID- 28575807
OWN - NLM
STAT- MEDLINE
DCOM- 20180403
LR  - 20220408
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 92
DP  - 2017 Aug
TI  - A holistic review on the autoimmune disease vitiligo with emphasis on the causal 
      factors.
PG  - 501-508
LID - S0753-3322(17)31751-1 [pii]
LID - 10.1016/j.biopha.2017.05.095 [doi]
AB  - Vitiligo is an idiopathic systemic autoimmune disease affecting skin, hair and 
      oral mucosa. This genetic yet acquired disease characterized by melanin loss is a 
      cause of morbidity across all races. Though thyroid disturbance has been 
      recognized as a key trigger of this pathology, an array of other factors plays 
      critical role in its manifestation. Multiple hormones (corticotropin-releasing 
      hormone, adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, 
      melatonin, calcitriol, testosterone, estrogen), genes (Human leukocyte antigen 
      (HLA), Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), Forkhead box D3 
      (FOXD3), Cluster of differentiation 117 (CD117), Estrogen receptor (ESR) 1, 
      Cyclooxygenase-2 (COX2), Vitiligo-associated protein 1 (VIT1)), and lifestyle 
      choices (stress, diet, cosmetic products, and medications) have been suspected as 
      drivers of this disorder. The pathological mechanisms have been understood in 
      recent times, with the aid of genomic studies; however a universally-effective 
      therapy is yet to be achieved. This review discusses these under-investigated 
      facets of vitiligo onset and progression; hence, it is expected to enrich 
      vitiligo research.
CI  - Copyright (c) 2017 Elsevier Masson SAS. All rights reserved.
FAU - Patel, Seema
AU  - Patel S
AD  - Bioinformatics and Medical Informatics Research Center, San Diego State 
      University, 5500 Campanile Dr, San Diego, 92182, USA. Electronic address: 
      seemabiotech83@gmail.com.
FAU - Rauf, Abdur
AU  - Rauf A
AD  - Department of Chemistry, University of Swabi, Anbar, 23561, K.P.K, Pakistan. 
      Electronic address: mashaljcs@yahoo.com.
FAU - Khan, Haroon
AU  - Khan H
AD  - Department of Pharmacy, Abdul Wali Khan University, Mardan, 23200, Pakistan.
FAU - Meher, Biswa Ranjan
AU  - Meher BR
AD  - Centre for Life Sciences, Central University of Jharkhand, Brambe, Ranchi, 
      835205, Jharkhand, India.
FAU - Hassan, Syed Shams Ul
AU  - Hassan SSU
AD  - Department of Marine Chemistry and Natural Products, Ocean College, Zhejiang 
      University, Hangzhou, 310058, PR China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170530
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Cosmetics)
RN  - 0 (Melanins)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - FXC9231JVH (Calcitriol)
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/chemically induced/*etiology/*metabolism
MH  - Calcitriol/metabolism
MH  - Cosmetics/adverse effects
MH  - Cyclooxygenase 2/metabolism
MH  - Humans
MH  - Life Style
MH  - Melanins/metabolism
MH  - Melanocytes/drug effects/metabolism
MH  - Oxidative Stress/drug effects/physiology
MH  - Vitiligo/chemically induced/*etiology/*metabolism
OTO - NOTNLM
OT  - Autoimmune disease
OT  - Melanin loss
OT  - Thyroid gland
OT  - Tyrosine
OT  - Vitiligo
EDAT- 2017/06/03 06:00
MHDA- 2018/04/04 06:00
CRDT- 2017/06/03 06:00
PHST- 2017/04/10 00:00 [received]
PHST- 2017/05/12 00:00 [revised]
PHST- 2017/05/22 00:00 [accepted]
PHST- 2017/06/03 06:00 [pubmed]
PHST- 2018/04/04 06:00 [medline]
PHST- 2017/06/03 06:00 [entrez]
AID - S0753-3322(17)31751-1 [pii]
AID - 10.1016/j.biopha.2017.05.095 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2017 Aug;92:501-508. doi: 10.1016/j.biopha.2017.05.095. Epub 
      2017 May 30.