PMID- 28576309
OWN - NLM
STAT- MEDLINE
DCOM- 20171219
LR  - 20230414
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 332
DP  - 2017 Aug 14
TI  - BNDF heterozygosity is associated with memory deficits and alterations in 
      cortical and hippocampal EEG power.
PG  - 154-163
LID - S0166-4328(17)30524-7 [pii]
LID - 10.1016/j.bbr.2017.05.039 [doi]
AB  - Brain derived neurotrophic factor (BDNF) plays a pivotal role in structural 
      plasticity, learning, and memory. Electroencephalogram (EEG) spectral power in 
      the cortex and hippocampus has also been correlated with learning and memory. In 
      this study, we investigated the effect of globally reduced BDNF levels on 
      learning behavior and EEG power via BDNF heterozygous (KO) rats. We employed 
      several behavioral tests that are thought to depend on cortical and hippocampal 
      plasticity to varying degrees: novel object recognition, a test that is reliant 
      on a variety of cognitive systems; contextual fear, which is highly 
      hippocampal-dependent; and cued fear, which has been shown to be 
      amygdala-dependent. We also examined the effects of BDNF reduction on cortical 
      and hippocampal EEG spectral power via chronically implanted electrodes in the 
      motor cortex and dorsal hippocampus. We found that BDNF KO rats were impaired in 
      novelty recognition and fear memory retention, while hippocampal EEG power was 
      decreased in slow waves and increased in fast waves. Interestingly, our results, 
      for the first time, show sexual dimorphism in each of our tests. These results 
      support the hypothesis that BDNF drives both cognitive plasticity and coordinates 
      EEG activity patterns, potentially serving as a link between the two.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Geist, Phillip A
AU  - Geist PA
AD  - Department of Anesthesiology, Graduate School of Medicine, The University of 
      Tennessee, 1924 Alcoa Highway, Knoxville, TN 37920, United States.
FAU - Dulka, Brooke N
AU  - Dulka BN
AD  - Department of Psychology, College of Arts and Sciences, 1404 Circle Drive, United 
      States.
FAU - Barnes, Abigail
AU  - Barnes A
AD  - Department of Anesthesiology, Graduate School of Medicine, The University of 
      Tennessee, 1924 Alcoa Highway, Knoxville, TN 37920, United States; Department of 
      Psychology, College of Arts and Sciences, 1404 Circle Drive, United States.
FAU - Totty, Michael
AU  - Totty M
AD  - Department of Anesthesiology, Graduate School of Medicine, The University of 
      Tennessee, 1924 Alcoa Highway, Knoxville, TN 37920, United States.
FAU - Datta, Subimal
AU  - Datta S
AD  - Department of Anesthesiology, Graduate School of Medicine, The University of 
      Tennessee, 1924 Alcoa Highway, Knoxville, TN 37920, United States; Department of 
      Psychology, College of Arts and Sciences, 1404 Circle Drive, United States; 
      Program in Comparative and Experimental Medicine, 2407 River Drive, RM A102, The 
      University of Tennessee, Knoxville, TN 37996, United States. Electronic address: 
      sdatta1@utk.edu.
LA  - eng
GR  - R01 MH059839/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Retracted Publication
DEP - 20170531
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
RIN - Behav Brain Res. 2023 May 28;446:114400. PMID: 37004410
MH  - Animals
MH  - Brain Waves/physiology
MH  - Brain-Derived Neurotrophic Factor/*deficiency/genetics
MH  - Electrocorticography
MH  - Exploratory Behavior/physiology
MH  - Fear/physiology
MH  - Female
MH  - Heterozygote
MH  - Hippocampus/*physiopathology
MH  - Learning/*physiology
MH  - Male
MH  - Memory Disorders/*physiopathology
MH  - Motor Cortex/*physiopathology
MH  - Rats, Sprague-Dawley
MH  - Rats, Transgenic
MH  - Recognition, Psychology/physiology
MH  - *Sex Characteristics
PMC - PMC5534188
MID - NIHMS883162
OTO - NOTNLM
OT  - Cortical theta
OT  - Fear acquisition
OT  - Fear retention
OT  - Hippocampal gamma
OT  - Novelty recognition
OT  - Rats
EDAT- 2017/06/04 06:00
MHDA- 2017/12/20 06:00
PMCR- 2018/08/14
CRDT- 2017/06/04 06:00
PHST- 2017/03/24 00:00 [received]
PHST- 2017/05/02 00:00 [revised]
PHST- 2017/05/11 00:00 [accepted]
PHST- 2017/06/04 06:00 [pubmed]
PHST- 2017/12/20 06:00 [medline]
PHST- 2017/06/04 06:00 [entrez]
PHST- 2018/08/14 00:00 [pmc-release]
AID - S0166-4328(17)30524-7 [pii]
AID - 10.1016/j.bbr.2017.05.039 [doi]
PST - ppublish
SO  - Behav Brain Res. 2017 Aug 14;332:154-163. doi: 10.1016/j.bbr.2017.05.039. Epub 
      2017 May 31.