PMID- 28576484
OWN - NLM
STAT- MEDLINE
DCOM- 20180502
LR  - 20221207
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 31
IP  - 8
DP  - 2017 Aug
TI  - Signs of subclinical atherosclerosis in asymptomatic patients at increased risk 
      of type 2 diabetes mellitus.
PG  - 1293-1298
LID - S1056-8727(17)30025-9 [pii]
LID - 10.1016/j.jdiacomp.2017.05.007 [doi]
AB  - AIMS: We aimed to study carotid intima media thickness (CIMT) in asymptomatic 
      patients with an increased risk of type 2 diabetes mellitus (T2DM) and in a 
      pre-diabetic state. METHODS: Diabetes risk assessment was performed in 2420 
      participants in a voluntary screening program between 2011 and 2013. The risk of 
      T2DM was estimated by the Findrisc scoring system (FR). A FR>/=12 was considered as 
      increased risk. HbA1c% between 5.7 and 6.4% signified a pre-diabetic state. 
      Carotid duplex scan was performed and CIMT above 0.9 mm was regarded as 
      pathological. Patients with T2DM or a history of cardiovascular disease were 
      excluded. RESULTS: Overall 1475 subjects were included. Four groups were 
      compared: "control" (normal HbA1c, FR<12), "HbA1c only" (HbA1c: 5.7-6.4%, FR<12), 
      "Findrisc only" (normal HbA1c, FR>/=12) and "combined" (HbA1c: 5.7-6.4%, FR>/=12). 
      Frequency of pathological maximal CIMT was 9.4%, 19.7%, 27.4% and 36.4% in the 
      groups, respectively (p<0.001). Logistic regression analysis revealed that 
      compared to control subjects, sex and risk factor-adjusted Odds Ratios for the 
      presence of pathological maximal CIMT were 2.2 (p<0.001), 3.4 (p<0.001) and 5.1 
      (p<0.001) for the groups, respectively. CONCLUSIONS: Evaluation of Findrisc score 
      and HbA1c at population level may facilitate early recognition of subclinical 
      vascular complications even in the pre-diabetic state.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Kiss, Loretta Zsuzsa
AU  - Kiss LZ
AD  - Heart and Vascular Center, Semmelweis University, Varosmajor Street 68, Budapest 
      H-1122, Hungary. Electronic address: kisslotti@gmail.com.
FAU - Bagyura, Zsolt
AU  - Bagyura Z
AD  - MTA-SE Lendulet Cardiovascular Imaging Research Group, Heart and Vascular Center, 
      Semmelweis University, Varosmajor Street 68, Budapest H-1122, Hungary. Electronic 
      address: bagyura@gmail.com.
FAU - Vadas, Reka
AU  - Vadas R
AD  - Heart and Vascular Center, Semmelweis University, Varosmajor Street 68, Budapest 
      H-1122, Hungary. Electronic address: vadasreka@gmail.com.
FAU - Polgar, Livia
AU  - Polgar L
AD  - Heart and Vascular Center, Semmelweis University, Varosmajor Street 68, Budapest 
      H-1122, Hungary. Electronic address: gorlicze@gmail.com.
FAU - Lux, Arpad
AU  - Lux A
AD  - Heart and Vascular Center, Semmelweis University, Varosmajor Street 68, Budapest 
      H-1122, Hungary. Electronic address: lux.arpad@gmail.com.
FAU - Edes, Eszter
AU  - Edes E
AD  - Heart and Vascular Center, Semmelweis University, Varosmajor Street 68, Budapest 
      H-1122, Hungary. Electronic address: eszti.edes@gmail.com.
FAU - Szenczi, Orsolya
AU  - Szenczi O
AD  - Heart and Vascular Center, Semmelweis University, Varosmajor Street 68, Budapest 
      H-1122, Hungary. Electronic address: oszenczi@yahoo.com.
FAU - Soos, Pal
AU  - Soos P
AD  - Heart and Vascular Center, Semmelweis University, Varosmajor Street 68, Budapest 
      H-1122, Hungary. Electronic address: soospal@gmail.com.
FAU - Szelid, Zsolt
AU  - Szelid Z
AD  - Heart and Vascular Center, Semmelweis University, Varosmajor Street 68, Budapest 
      H-1122, Hungary. Electronic address: szelid.zsolt@kardio.sote.hu.
FAU - Becker, David
AU  - Becker D
AD  - Heart and Vascular Center, Semmelweis University, Varosmajor Street 68, Budapest 
      H-1122, Hungary. Electronic address: becdavid@gmail.com.
FAU - Jermendy, Gyorgy
AU  - Jermendy G
AD  - Bajcsy-Zsilinszky Hospital, Maglodi Street 89-91, Budapest H-1106, Hungary. 
      Electronic address: gyjermendy@mail.datanet.hu.
FAU - Merkely, Bela
AU  - Merkely B
AD  - Heart and Vascular Center, Semmelweis University, Varosmajor Street 68, Budapest 
      H-1122, Hungary. Electronic address: merkely.bela@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20170525
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Biomarkers)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Asymptomatic Diseases/epidemiology
MH  - Atherosclerosis/blood/complications/*diagnostic imaging/epidemiology
MH  - Biomarkers/blood
MH  - Carotid Intima-Media Thickness
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/complications/*diagnosis/epidemiology
MH  - Diabetic Angiopathies/blood/*diagnostic imaging/epidemiology
MH  - *Early Diagnosis
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Health Surveys
MH  - Humans
MH  - Hungary/epidemiology
MH  - Male
MH  - Mass Screening
MH  - Middle Aged
MH  - Prediabetic State/complications/*diagnosis/epidemiology
MH  - Prevalence
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Cardiovascular complications
OT  - Carotid intima media thickness
OT  - Findrisc score
OT  - Prediabetes
OT  - Subclinical atherosclerosis
EDAT- 2017/06/04 06:00
MHDA- 2018/05/03 06:00
CRDT- 2017/06/04 06:00
PHST- 2017/01/11 00:00 [received]
PHST- 2017/05/15 00:00 [revised]
PHST- 2017/05/17 00:00 [accepted]
PHST- 2017/06/04 06:00 [pubmed]
PHST- 2018/05/03 06:00 [medline]
PHST- 2017/06/04 06:00 [entrez]
AID - S1056-8727(17)30025-9 [pii]
AID - 10.1016/j.jdiacomp.2017.05.007 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2017 Aug;31(8):1293-1298. doi: 
      10.1016/j.jdiacomp.2017.05.007. Epub 2017 May 25.