PMID- 28576603
OWN - NLM
STAT- MEDLINE
DCOM- 20180423
LR  - 20180423
IS  - 1873-5126 (Electronic)
IS  - 1353-8020 (Linking)
VI  - 41
DP  - 2017 Aug
TI  - Association of low serum BDNF with depression in patients with Parkinson's 
      disease.
PG  - 73-78
LID - S1353-8020(17)30178-5 [pii]
LID - 10.1016/j.parkreldis.2017.05.012 [doi]
AB  - OBJECTIVE: Increasing evidence shows that brain-derived neurotrophic factor 
      (BDNF) plays a critical role in the development of depression and the mechanisms 
      of antidepressant. Parkinson disease (PD) is associated with depression and 
      decreased BDNF. The aim of the present study was to examine the association of 
      BDNF with depression in PD, which has not been investigated. METHODS: We 
      recruited 96 PD patients with (n = 46) and without depression (n = 50) and 102 
      healthy controls and measured the serum BDNF levels in both groups. Zung 
      Self-Rating Depression Scale (SDS) was administered for the severity of 
      depression and Hoehn-Yahr staging scale for motor abilities in PD patients. 
      RESULTS: Serum BDNF levels were significantly lower in PD patients than healthy 
      controls (p < 0.01). Also serum BDNF levels were significantly decreased in PD 
      patients with than without depression (p < 0.01). BDNF levels were negatively 
      associated with SDS in both PD patients with and without depression (both 
      p < 0.01). Multiple regression analysis confirmed that in either PD with or 
      without depression group, BDNF was an independent contributor to SDS (both 
      p < 0.05). CONCLUSIONS: Our findings suggest that decreased serum BDNF may be 
      involved in the pathophysiology of depression in PD patients.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Wang, Yu
AU  - Wang Y
AD  - Department of Neurology, Tianjin Medical University General Hospital, Tianjin 
      300052, China.
FAU - Liu, Hong
AU  - Liu H
AD  - Department of Neurology, Heping Hospital Af fi liated to Changzhi Medical College, 
      Shanxi Province, China.
FAU - Du, Xiang-Dong
AU  - Du XD
AD  - Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow 
      University, Jiangsu, China.
FAU - Zhang, Yingyang
AU  - Zhang Y
AD  - Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow 
      University, Jiangsu, China.
FAU - Yin, Guangzhong
AU  - Yin G
AD  - Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow 
      University, Jiangsu, China.
FAU - Zhang, Ben-Shu
AU  - Zhang BS
AD  - Department of Neurology, Tianjin Medical University General Hospital, Tianjin 
      300052, China.
FAU - Soares, Jair C
AU  - Soares JC
AD  - Department of Psychiatry and Behavioral Sciences, The University of Texas Health 
      Science Center at Houston, Houston, TX, USA.
FAU - Zhang, Xiang Yang
AU  - Zhang XY
AD  - Beijing HuiLongGuan Hospital, Peking University, Beijing, China. Electronic 
      address: zhangxy9@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20170517
PL  - England
TA  - Parkinsonism Relat Disord
JT  - Parkinsonism & related disorders
JID - 9513583
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Analysis of Variance
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - China
MH  - Depression/*blood/*complications/ethnology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*blood/*complications/ethnology
MH  - Psychiatric Status Rating Scales
MH  - Statistics as Topic
OTO - NOTNLM
OT  - Association
OT  - BDNF
OT  - Depression
OT  - Parkinson's disease
EDAT- 2017/06/04 06:00
MHDA- 2018/04/24 06:00
CRDT- 2017/06/04 06:00
PHST- 2017/02/25 00:00 [received]
PHST- 2017/04/30 00:00 [revised]
PHST- 2017/05/17 00:00 [accepted]
PHST- 2017/06/04 06:00 [pubmed]
PHST- 2018/04/24 06:00 [medline]
PHST- 2017/06/04 06:00 [entrez]
AID - S1353-8020(17)30178-5 [pii]
AID - 10.1016/j.parkreldis.2017.05.012 [doi]
PST - ppublish
SO  - Parkinsonism Relat Disord. 2017 Aug;41:73-78. doi: 
      10.1016/j.parkreldis.2017.05.012. Epub 2017 May 17.