PMID- 28576622
OWN - NLM
STAT- MEDLINE
DCOM- 20171116
LR  - 20181202
IS  - 1873-2380 (Electronic)
IS  - 0021-9290 (Linking)
VI  - 58
DP  - 2017 Jun 14
TI  - Haemodynamic effects of stent diameter and compaction ratio on flow-diversion 
      treatment of intracranial aneurysms: A numerical study of a successful and an 
      unsuccessful case.
PG  - 179-186
LID - S0021-9290(17)30242-7 [pii]
LID - 10.1016/j.jbiomech.2017.05.001 [doi]
AB  - BACKGROUND: Compacting a flow-diverting (FD) stent is an emerging technique to 
      create a denser configuration of wires across the aneurysm ostium. However, 
      quantitative analyses of post-stenting haemodynamics affected by the compaction 
      level of different stent sizes remain inconclusive. OBJECTIVE: To compare the 
      aneurysmal haemodynamic alterations after virtual FD treatments with different 
      device diameters at different compaction ratios. METHODS: We virtually implanted 
      three sizes of FD stent, with each size deployed at four compaction ratios, into 
      two patient aneurysms previously treated with the Silk+FD-one successful case and 
      the other unsuccessful. Wire configurations of the FD in the 24 treatment 
      scenarios were examined, and aneurysmal haemodynamic alterations were resolved by 
      computational fluid dynamics (CFD) simulations. We investigated the aneurysmal 
      flow patterns, aneurysmal average velocity (AAV), mass flowrate (MF), and energy 
      loss (EL) in each scenario. RESULTS: Compactions of the stent in the successful 
      case resulted in a greater metal coverage rate than that achieved in the 
      unsuccessful one. A 25% increment in compaction ratio further decreased the AAV 
      (12%), MF (11%), and EL (9%) in both cases (average values). The averaged maximum 
      differences attributable to device size were 10% (AAV), 8% (MF), and 9% (EL). 
      CONCLUSIONS: Both stent size and compaction level could markedly affect the FD 
      treatment outcomes. It is therefore important to individualise the treatment plan 
      by selecting the optimal stent size and deployment procedure. CFD simulation can 
      be used to investigate the treatment outcomes, thereby assisting doctors in 
      choosing a favourable treatment plan.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Zhang, Mingzi
AU  - Zhang M
AD  - Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 
      Macquarie University, Sydney, New South Wales, Australia; Graduate School of 
      Engineering, Tohoku University, Sendai, Miyagi, Japan.
FAU - Li, Yujie
AU  - Li Y
AD  - Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 
      Macquarie University, Sydney, New South Wales, Australia; Graduate School of 
      Engineering, Tohoku University, Sendai, Miyagi, Japan.
FAU - Zhao, Xi
AU  - Zhao X
AD  - Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 
      Macquarie University, Sydney, New South Wales, Australia.
FAU - Verrelli, David I
AU  - Verrelli DI
AD  - Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 
      Macquarie University, Sydney, New South Wales, Australia.
FAU - Chong, Winston
AU  - Chong W
AD  - Neuroradiology Department, Monash Medical Centre, Melbourne, Victoria, Australia; 
      Department of Surgery, School of Clinical Sciences, Faculty of Medicine, Nursing 
      and Health Sciences, Monash University, Clayton, Victoria, Australia.
FAU - Ohta, Makoto
AU  - Ohta M
AD  - Institute of Fluid Science, Tohoku University, Sendai, Miyagi, Japan.
FAU - Qian, Yi
AU  - Qian Y
AD  - Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 
      Macquarie University, Sydney, New South Wales, Australia. Electronic address: 
      yi.qian@mq.edu.au.
LA  - eng
PT  - Journal Article
DEP - 20170516
PL  - United States
TA  - J Biomech
JT  - Journal of biomechanics
JID - 0157375
SB  - IM
MH  - Hemodynamics
MH  - Humans
MH  - Hydrodynamics
MH  - Intracranial Aneurysm/physiopathology/*therapy
MH  - *Stents
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Compaction ratio
OT  - Computational fluid dynamics
OT  - Device diameter
OT  - Flow-diverting stent
OT  - Intracranial aneurysm
EDAT- 2017/06/04 06:00
MHDA- 2017/11/29 06:00
CRDT- 2017/06/04 06:00
PHST- 2017/01/01 00:00 [received]
PHST- 2017/04/02 00:00 [revised]
PHST- 2017/05/05 00:00 [accepted]
PHST- 2017/06/04 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2017/06/04 06:00 [entrez]
AID - S0021-9290(17)30242-7 [pii]
AID - 10.1016/j.jbiomech.2017.05.001 [doi]
PST - ppublish
SO  - J Biomech. 2017 Jun 14;58:179-186. doi: 10.1016/j.jbiomech.2017.05.001. Epub 2017 
      May 16.