PMID- 28576669
OWN - NLM
STAT- MEDLINE
DCOM- 20171213
LR  - 20191210
IS  - 1531-5053 (Electronic)
IS  - 0278-2391 (Linking)
VI  - 75
IP  - 12
DP  - 2017 Dec
TI  - Impact of Autologous Bone Marrow-Derived Stem Cells on Degenerative Changes of 
      Articulating Surfaces Associated With the Arthritic Temporomandibular Joint: An 
      Experimental Study in Rabbits.
PG  - 2529-2539
LID - S0278-2391(17)30501-3 [pii]
LID - 10.1016/j.joms.2017.05.001 [doi]
AB  - PURPOSE: This study evaluated the effect of bone marrow-derived stem cells 
      (BMSCs) on degenerative changes of TMJ associated with bovine collagen type II 
      (BCII) induced-arthritis. MATERIALS AND METHODS: Fifty rabbits were divided into 
      3 groups. Group I (n = 10) received no treatment. Group II (n = 20) was divided 
      into 2 subgroups according to treatment type. One subgroup (n = 10) received an 
      intra-articular (IA) injection of phosphate buffered saline (PBS) and the other 
      (n = 10) received an IA injection of PBS plus BMSCs. Group III (n = 20) received 
      an injection of oil emulsion of BCII before treatment with PBS or PBS plus BMSCs 
      as in group II. Rabbits were euthanized after the third week and the joints were 
      processed for histology. RESULTS: Compared to TMJs of subgroup III treated with 
      PBS, TMJs of subgroup III treated with combined therapy showed improvements in 
      all parameters tested. Mean values in mm(3) for this subgroup regarding fibrous 
      condylar covering, cartilaginous condylar plate, subchondral bone, articular 
      eminence, upper joint cavity, lower joint cavity and disc thickness were 
      4.04+/-0.13, 5.09+/-0.08, 25.29+/-0.36, 10.54+/-0.36, 4.53+/-0.44, 3.21+/-0.27, and 
      24.52+/-0.41, respectively. Significant differences were found between subgroups 
      mean values of group II and group IIII. CONCLUSIONS: BMSCs can be used safely and 
      effectively to repair degenerative changes in rabbit TMJs associated with 
      BCII-induced arthritis.
CI  - Copyright (c) 2017 American Association of Oral and Maxillofacial Surgeons. 
      Published by Elsevier Inc. All rights reserved.
FAU - Zaki, Ahmed Abdelfatah
AU  - Zaki AA
AD  - Colleague of Master Degree of Oral and Maxillofacial Surgery, Mansoura, Egypt.
FAU - Zaghloul, Mohamed
AU  - Zaghloul M
AD  - Associate Professor, Department of Oral Surgery, Faculty of Dentistry, Mansoura 
      University, Mansoura, Egypt.
FAU - Helal, Mohamed E
AU  - Helal ME
AD  - Professor, Department of Oral Biology, Faculty of Dentistry, Mansoura University, 
      Mansoura, Egypt.
FAU - Mansour, Noha Ahmed
AU  - Mansour NA
AD  - Lecturer, Department of Oral Surgery, Faculty of Dentistry, Mansoura University, 
      Mansoura, Egypt.
FAU - Grawish, Mohammed E
AU  - Grawish ME
AD  - Professor, Department of Oral Biology, Faculty of Dentistry, Mansoura University; 
      Department of Oral Biology, Faculty of Oral and Dental Medicine, Delta University 
      for Science and Technology, Gamasa, Mansoura, Egypt. Electronic address: 
      grawish2005@yahoo.com.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20170510
PL  - United States
TA  - J Oral Maxillofac Surg
JT  - Journal of oral and maxillofacial surgery : official journal of the American 
      Association of Oral and Maxillofacial Surgeons
JID - 8206428
SB  - IM
MH  - Animals
MH  - Arthritis/pathology/*therapy
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Male
MH  - Rabbits
MH  - Random Allocation
MH  - Temporomandibular Joint/*pathology
MH  - Temporomandibular Joint Disorders/pathology/*therapy
MH  - Transplantation, Autologous
MH  - Treatment Outcome
EDAT- 2017/06/04 06:00
MHDA- 2017/12/14 06:00
CRDT- 2017/06/04 06:00
PHST- 2017/03/27 00:00 [received]
PHST- 2017/05/02 00:00 [revised]
PHST- 2017/05/02 00:00 [accepted]
PHST- 2017/06/04 06:00 [pubmed]
PHST- 2017/12/14 06:00 [medline]
PHST- 2017/06/04 06:00 [entrez]
AID - S0278-2391(17)30501-3 [pii]
AID - 10.1016/j.joms.2017.05.001 [doi]
PST - ppublish
SO  - J Oral Maxillofac Surg. 2017 Dec;75(12):2529-2539. doi: 
      10.1016/j.joms.2017.05.001. Epub 2017 May 10.