PMID- 28577123
OWN - NLM
STAT- MEDLINE
DCOM- 20180709
LR  - 20201209
IS  - 1573-0832 (Electronic)
IS  - 0301-486X (Linking)
VI  - 182
IP  - 9-10
DP  - 2017 Oct
TI  - Hepatic Disease with Portal Hypertension and Acute Juvenile 
      Paracoccidioidomycosis: A Report of Two Cases and Literature Review.
PG  - 915-919
LID - 10.1007/s11046-017-0152-6 [doi]
AB  - Paracoccidioidomycosis (PCM) is a neglected systemic mycosis endemic to Latin 
      America caused by dimorphic fungi of the genus Paracoccidioides. The acute 
      juvenile PCM is a severe type of presentation that usually affects young 
      vulnerable patients and rarely progresses to portal hypertension. Here, two cases 
      of liver disease and portal hypertension as complications of acute juvenile PCM 
      are reported. Diagnosis of PCM was performed by isolation of the fungus and 
      molecular identification of the strains provided through partial sequencing of 
      two protein encoding genes, arf and gp43. Genotypic analysis revealed that 
      Paracoccidioides brasiliensis S1 was the phylogenic species involved in both 
      cases. Patients presented a good clinical response to amphotericin B and 
      sulfamethoxazole-trimethoprim. These results highlight the importance of the 
      interdisciplinary approach in patients with severe forms of PCM to avoid and 
      treat complications, and the necessity of further investigations focusing on 
      host-pathogen interaction in order to explain the broad clinical spectrum in PCM 
      as well as the severity and poor outcome in some clinical cases.
FAU - de Macedo, Priscila Marques
AU  - de Macedo PM
AD  - Infectious Dermatology Clinical Research Laboratory, Evandro Chagas National 
      Institute of Infectious Diseases, Fiocruz, Rio de Janeiro, Brazil. 
      priscila.marques@ini.fiocruz.br.
AD  - Laboratorio de Pesquisa Clinica em Dermatologia Infecciosa, Instituto Nacional de 
      Infectologia Evandro Chagas, Fundacao Oswaldo Cruz, Avenida Brasil, 4365, 
      Manguinhos, Rio de Janeiro, 21045-900, Brazil. priscila.marques@ini.fiocruz.br.
FAU - Almeida-Paes, Rodrigo
AU  - Almeida-Paes R
AD  - Mycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, 
      Fiocruz, Rio de Janeiro, Brazil.
FAU - Freitas, Dayvison Francis Saraiva
AU  - Freitas DFS
AD  - Infectious Dermatology Clinical Research Laboratory, Evandro Chagas National 
      Institute of Infectious Diseases, Fiocruz, Rio de Janeiro, Brazil.
FAU - Brito-Santos, Fabio
AU  - Brito-Santos F
AD  - Mycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, 
      Fiocruz, Rio de Janeiro, Brazil.
FAU - Figueiredo-Carvalho, Maria Helena Galdino
AU  - Figueiredo-Carvalho MHG
AD  - Mycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, 
      Fiocruz, Rio de Janeiro, Brazil.
FAU - de Almeida Soares, Joao Carlos
AU  - de Almeida Soares JC
AD  - Department of Gastroenterology, Evandro Chagas National Institute of Infectious 
      Diseases, Fiocruz, Rio de Janeiro, Brazil.
FAU - Freitas, Andrea D'Avila
AU  - Freitas AD
AD  - Department of Inpatient Health Care, Evandro Chagas National Institute of 
      Infectious Diseases, Fiocruz, Rio de Janeiro, Brazil.
FAU - Zancope-Oliveira, Rosely Maria
AU  - Zancope-Oliveira RM
AD  - Mycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, 
      Fiocruz, Rio de Janeiro, Brazil.
FAU - do Valle, Antonio Carlos Francesconi
AU  - do Valle ACF
AD  - Department of Inpatient Health Care, Evandro Chagas National Institute of 
      Infectious Diseases, Fiocruz, Rio de Janeiro, Brazil.
LA  - eng
GR  - 304976/2013-0/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/
GR  - E-26/010.002203/2015/Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado 
      do Rio de Janeiro/
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20170602
PL  - Netherlands
TA  - Mycopathologia
JT  - Mycopathologia
JID - 7505689
RN  - 0 (Fungal Proteins)
RN  - 7XU7A7DROE (Amphotericin B)
RN  - 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Amphotericin B/therapeutic use
MH  - Female
MH  - Fungal Proteins/genetics
MH  - Humans
MH  - Hypertension, Portal/*etiology/*pathology
MH  - Latin America
MH  - Liver Diseases/*etiology/*pathology
MH  - Male
MH  - Paracoccidioides/classification/genetics/*isolation & purification
MH  - Paracoccidioidomycosis/*complications/*diagnosis/drug therapy
MH  - Phylogeny
MH  - Sequence Analysis, DNA
MH  - Treatment Outcome
MH  - Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use
OTO - NOTNLM
OT  - Acute juvenile paracoccidioidomycosis
OT  - Complications
OT  - Hepatic disease
OT  - Paracoccidioides brasiliensis S1
OT  - Portal hypertension
EDAT- 2017/06/04 06:00
MHDA- 2018/07/10 06:00
CRDT- 2017/06/04 06:00
PHST- 2016/12/28 00:00 [received]
PHST- 2017/05/22 00:00 [accepted]
PHST- 2017/06/04 06:00 [pubmed]
PHST- 2018/07/10 06:00 [medline]
PHST- 2017/06/04 06:00 [entrez]
AID - 10.1007/s11046-017-0152-6 [pii]
AID - 10.1007/s11046-017-0152-6 [doi]
PST - ppublish
SO  - Mycopathologia. 2017 Oct;182(9-10):915-919. doi: 10.1007/s11046-017-0152-6. Epub 
      2017 Jun 2.