PMID- 28578131 OWN - NLM STAT- MEDLINE DCOM- 20180528 LR - 20210109 IS - 1095-9572 (Electronic) IS - 1053-8119 (Print) IS - 1053-8119 (Linking) VI - 157 DP - 2017 Aug 15 TI - Predicting behavior change from persuasive messages using neural representational similarity and social network analyses. PG - 118-128 LID - S1053-8119(17)30464-0 [pii] LID - 10.1016/j.neuroimage.2017.05.063 [doi] AB - Neural activity in medial prefrontal cortex (MPFC), identified as engaging in self-related processing, predicts later health behavior change. However, it is unknown to what extent individual differences in neural representation of content and lived experience influence this brain-behavior relationship. We examined whether the strength of content-specific representations during persuasive messaging relates to later behavior change, and whether these relationships change as a function of individuals' social network composition. In our study, smokers viewed anti-smoking messages while undergoing fMRI and we measured changes in their smoking behavior one month later. Using representational similarity analyses, we found that the degree to which message content (i.e. health, social, or valence information) was represented in a self-related processing MPFC region was associated with later smoking behavior, with increased representations of negatively valenced (risk) information corresponding to greater message-consistent behavior change. Furthermore, the relationship between representations and behavior change depended on social network composition: smokers who had proportionally fewer smokers in their network showed increases in smoking behavior when social or health content was strongly represented in MPFC, whereas message-consistent behavior (i.e., less smoking) was more likely for those with proportionally more smokers in their social network who represented social or health consequences more strongly. These results highlight the dynamic relationship between representations in MPFC and key outcomes such as health behavior change; a complete understanding of the role of MPFC in motivation and action should take into account individual differences in neural representation of stimulus attributes and social context variables such as social network composition. CI - Copyright (c) 2017 Elsevier Inc. All rights reserved. FAU - Pegors, Teresa K AU - Pegors TK AD - Department of Psychology Azusa Pacific University, 901 E Alosta Ave., Azusa, CA 91702, USA. Electronic address: tpegors@apu.edu. FAU - Tompson, Steven AU - Tompson S AD - Department of Bioengineering University of Pennsylvania, 210 South 33rd St Suit 240 Skirkanich Hall, Philadelphia, PA 19104, USA. Electronic address: stevro@seas.upenn.edu. FAU - O'Donnell, Matthew Brook AU - O'Donnell MB AD - Annenberg School for Communication University of Pennsylvania, 3620 Walnut St, Philadelphia, PA 19104, USA. Electronic address: mbod@asc.upenn.edu. FAU - Falk, Emily B AU - Falk EB AD - Annenberg School for Communication University of Pennsylvania, 3620 Walnut St, Philadelphia, PA 19104, USA. Electronic address: falk@asc.upenn.edu. LA - eng GR - DP2 DA035156/DA/NIDA NIH HHS/United States GR - P50 CA101451/CA/NCI NIH HHS/United States GR - P50 CA179546/CA/NCI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20170531 PL - United States TA - Neuroimage JT - NeuroImage JID - 9215515 SB - IM MH - Adult MH - Brain Mapping/*methods MH - Female MH - Health Behavior/*physiology MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Motivation/*physiology MH - *Persuasive Communication MH - Prefrontal Cortex/*physiology MH - *Smoking MH - *Social Support MH - Young Adult PMC - PMC5821423 MID - NIHMS882933 OTO - NOTNLM OT - FMRI OT - Health behavior OT - Motivation OT - Multivariate analyses OT - RSA OT - Smoking EDAT- 2017/06/05 06:00 MHDA- 2018/05/29 06:00 PMCR- 2018/08/15 CRDT- 2017/06/05 06:00 PHST- 2017/01/07 00:00 [received] PHST- 2017/04/22 00:00 [revised] PHST- 2017/05/30 00:00 [accepted] PHST- 2017/06/05 06:00 [pubmed] PHST- 2018/05/29 06:00 [medline] PHST- 2017/06/05 06:00 [entrez] PHST- 2018/08/15 00:00 [pmc-release] AID - S1053-8119(17)30464-0 [pii] AID - 10.1016/j.neuroimage.2017.05.063 [doi] PST - ppublish SO - Neuroimage. 2017 Aug 15;157:118-128. doi: 10.1016/j.neuroimage.2017.05.063. Epub 2017 May 31.