PMID- 28580666
OWN - NLM
STAT- MEDLINE
DCOM- 20180622
LR  - 20181206
IS  - 1097-4547 (Electronic)
IS  - 0360-4012 (Print)
IS  - 0360-4012 (Linking)
VI  - 96
IP  - 1
DP  - 2018 Jan
TI  - Connexins and pannexins: At the junction of neuro-glial homeostasis & disease.
PG  - 31-44
LID - 10.1002/jnr.24088 [doi]
AB  - In the central nervous system (CNS), connexin (Cx)s and pannexin (Panx)s are an 
      integral component of homeostatic neuronal excitability and synaptic plasticity. 
      Neuronal Cx gap junctions form electrical synapses across biochemically similar 
      GABAergic networks, allowing rapid and extensive inhibition in response to 
      principle neuron excitation. Glial Cx gap junctions link astrocytes and 
      oligodendrocytes in the pan-glial network that is responsible for removing 
      excitotoxic ions and metabolites. In addition, glial gap junctions help constrain 
      excessive excitatory activity in neurons and facilitate astrocyte Ca(2+) slow 
      wave propagation. Panxs do not form gap junctions in vivo, but Panx hemichannels 
      participate in autocrine and paracrine gliotransmission, alongside Cx 
      hemichannels. ATP and other gliotransmitters released by Cx and Panx hemichannels 
      maintain physiologic glutamatergic tone by strengthening synapses and mitigating 
      aberrant high frequency bursting. Under pathological depolarizing and 
      inflammatory conditions, gap junctions and hemichannels become dysregulated, 
      resulting in excessive neuronal firing and seizure. In this review, we present 
      known contributions of Cxs and Panxs to physiologic neuronal excitation and 
      explore how the disruption of gap junctions and hemichannels lead to abnormal 
      glutamatergic transmission, purinergic signaling, and seizures.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Lapato, Andrew S
AU  - Lapato AS
AD  - Division of Biomedical Sciences, School of Medicine, University of California 
      Riverside, Riverside, CA, 92521.
AD  - Center for Glial-Neuronal Interactions, University of California Riverside, 
      Riverside, CA, 92521.
FAU - Tiwari-Woodruff, Seema K
AU  - Tiwari-Woodruff SK
AUID- ORCID: 0000-0001-7608-4763
AD  - Division of Biomedical Sciences, School of Medicine, University of California 
      Riverside, Riverside, CA, 92521.
AD  - Center for Glial-Neuronal Interactions, University of California Riverside, 
      Riverside, CA, 92521.
AD  - Neuroscience Graduate Program, University of California Riverside, Riverside, CA, 
      92521.
LA  - eng
GR  - R01 NS081141/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20170605
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Connexins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (PANX1 protein, human)
SB  - IM
MH  - Animals
MH  - Calcium Signaling/physiology
MH  - Central Nervous System Diseases/*metabolism/pathology
MH  - Connexins/chemistry/*metabolism
MH  - Gap Junctions/chemistry/*metabolism
MH  - Homeostasis/*physiology
MH  - Humans
MH  - Nerve Tissue Proteins/chemistry/metabolism
MH  - Neuroglia/chemistry/*metabolism/pathology
PMC - PMC5749981
MID - NIHMS874015
OTO - NOTNLM
OT  - astrocyte
OT  - connexin
OT  - electrical synapse
OT  - epilepsy
OT  - gap junction
OT  - gliotransmission
OT  - hemichannel
OT  - neuronal excitability
OT  - pan-glial network
OT  - pannexin
OT  - purinergic signaling
OT  - seizure
OT  - synaptic plasticity
COIS- Conflict of interest statement: The authors have no conflicts of interest, 
      including any financial, personal, or other relationships with people or 
      organizations that could influence the present article.
EDAT- 2017/06/06 06:00
MHDA- 2018/06/23 06:00
PMCR- 2018/07/01
CRDT- 2017/06/06 06:00
PHST- 2017/02/07 00:00 [received]
PHST- 2017/04/08 00:00 [revised]
PHST- 2017/05/01 00:00 [accepted]
PHST- 2017/06/06 06:00 [pubmed]
PHST- 2018/06/23 06:00 [medline]
PHST- 2017/06/06 06:00 [entrez]
PHST- 2018/07/01 00:00 [pmc-release]
AID - 10.1002/jnr.24088 [doi]
PST - ppublish
SO  - J Neurosci Res. 2018 Jan;96(1):31-44. doi: 10.1002/jnr.24088. Epub 2017 Jun 5.