PMID- 28581270
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20181113
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 32
IP  - 7
DP  - 2017 Jul
TI  - Potential Association of Triglyceride Glucose Index with Cardiac Autonomic 
      Neuropathy in Type 2 Diabetes Mellitus Patients.
PG  - 1131-1138
LID - 10.3346/jkms.2017.32.7.1131 [doi]
AB  - Cardiac autonomic neuropathy (CAN) is a common and most neglected complication of 
      diabetes, estimated to be roughly 8% in recently diagnosed patients and greater 
      than 50% in patients with chronic disease history. The insulin resistance (IR) 
      itself is bidirectionally associated with increased risk of type 2 diabetes 
      mellitus (T2DM) and CAN is a predisposing factor. The primary objective of the 
      present study was aimed to find a correlation of triglyceride glucose index (TyG 
      index) in CAN patients along with the prevalence of CAN in T2DM patients as a 
      secondary objective. This prevalence study was conducted on 202 patients visiting 
      the diabetic clinic of Hamdard Institute of Medical Sciences and Research, Jamia 
      Hamdard (HIMSR) teaching hospital in New Delhi, India who fulfilled the inclusion 
      criteria. The Ewings autonomic function test was used for diagnosis of CAN. TyG 
      index was calculated for patients based on fasting levels of glucose and 
      triglyceride. The CAN was diagnosed in 62 participants out of 202 T2DM patients 
      (overall prevalence 30.7%). The mean +/- standard deviation (SD) for TyG index was 
      10.3 +/- 0.2 and 9.5 +/- 0.2 in CAN positive, T2DM patients, respectively. The 
      difference of TyG index, in CAN positive and T2DM patients, was highly 
      significant (P < 0.001). Further correlation analysis was performed to find an 
      association of TyG index, duration, and age with patient groups. TyG index showed 
      a positive correlation with heart rate during deep breathing (HRD), heart rate 
      variation during standing (HRS), blood pressure (BP) response to handgrip and BP 
      response to standing. Our finding highlights the TyG index, low-cost IR index, 
      might be useful as an alternative tool for the early screening of patients at a 
      high risk of diabetic neuropathy.
CI  - (c) 2017 The Korean Academy of Medical Sciences.
FAU - Akbar, Md
AU  - Akbar M
AUID- ORCID: 0000-0002-5117-9413
AD  - Department of Pharmaceutical Medicine, Faculty of Pharmacy, Hamdard University, 
      New Delhi, India.
FAU - Bhandari, Uma
AU  - Bhandari U
AUID- ORCID: 0000-0003-2277-9142
AD  - Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi, 
      India. uma_bora@hotmail.com.
FAU - Habib, Anwar
AU  - Habib A
AUID- ORCID: 0000-0003-3589-8810
AD  - Department of Medicine, Hamdard Institute of Medical Sciences and Research, 
      Hamdard University, New Delhi, India.
FAU - Ahmad, Razi
AU  - Ahmad R
AUID- ORCID: 0000-0002-9541-5633
AD  - Department of Pharmacology, Hamdard Institute of Medical Sciences and Research, 
      Hamdard University, New Delhi, India.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 0 (Blood Glucose)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Glucose/*analysis
MH  - Blood Pressure/physiology
MH  - Diabetes Mellitus, Type 2/blood/complications/*pathology
MH  - Diabetic Neuropathies/complications/*pathology
MH  - Female
MH  - Hand Strength/physiology
MH  - Heart Diseases/complications/*pathology
MH  - Heart Rate/physiology
MH  - Humans
MH  - Insulin Resistance/physiology
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Triglycerides/*blood
MH  - Young Adult
PMC - PMC5461317
OTO - NOTNLM
OT  - Autonomic Function Test
OT  - Cardiac Autonomic Neuropathy
OT  - Insulin Resistance
OT  - Triglyceride Glucose Index
OT  - Type 2 Diabetes Mellitus
COIS- The authors have no potential conflicts of interest to disclose.
EDAT- 2017/06/06 06:00
MHDA- 2018/03/27 06:00
PMCR- 2017/07/01
CRDT- 2017/06/06 06:00
PHST- 2016/12/19 00:00 [received]
PHST- 2017/03/19 00:00 [accepted]
PHST- 2017/07/01 00:00 [pmc-release]
PHST- 2017/06/06 06:00 [entrez]
PHST- 2017/06/06 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
AID - 32.1131 [pii]
AID - 10.3346/jkms.2017.32.7.1131 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2017 Jul;32(7):1131-1138. doi: 10.3346/jkms.2017.32.7.1131.