PMID- 28581998
OWN - NLM
STAT- MEDLINE
DCOM- 20181018
LR  - 20181018
IS  - 2211-7466 (Electronic)
IS  - 2211-7458 (Linking)
VI  - 5
IP  - 4
DP  - 2016 Oct
TI  - Controversies in the Management of ST Elevation Myocardial Infarction: Thrombin 
      Inhibition.
PG  - 497-511
LID - S2211-7458(16)30063-3 [pii]
LID - 10.1016/j.iccl.2016.06.008 [doi]
AB  - Anticoagulation is essential in patients with ST elevation myocardial infarction 
      (STEMI) to prevent further thrombosis and to maintain patency of the 
      infarct-related artery after reperfusion. The various anticoagulant medications 
      available for use in patients with STEMI include unfractionated heparin (UFH), 
      low-molecular-weight heparin, fondaparinux, and bivalirudin, a direct thrombin 
      inhibitor. The authors review the current anticoagulation strategies for patients 
      with STEMI undergoing primary percutaneous coronary intervention (PCI), 
      fibrinolysis, or no reperfusion. The authors present the latest evidence and 
      controversies on this topic, with a focus on bivalirudin versus UFH in the 
      setting of primary PCI for STEMI.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Shah, Neeraj
AU  - Shah N
AD  - Department of Cardiology, Lehigh Valley Heath Network, 1250 S Cedar Crest 
      Boulevard, Allentown, PA 18103, USA.
FAU - Cox, David
AU  - Cox D
AD  - Department of Cardiology, Lehigh Valley Heath Network, 1250 S Cedar Crest 
      Boulevard, Allentown, PA 18103, USA. Electronic address: david.cox@lvhn.org.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160810
PL  - Netherlands
TA  - Interv Cardiol Clin
JT  - Interventional cardiology clinics
JID - 101615153
RN  - 0 (Fibrinolytic Agents)
RN  - 9005-49-6 (Heparin)
RN  - EC 3.4.21.5 (Thrombin)
SB  - IM
MH  - Fibrinolytic Agents/therapeutic use
MH  - Heparin/therapeutic use
MH  - Humans
MH  - *Percutaneous Coronary Intervention
MH  - ST Elevation Myocardial Infarction/*therapy
MH  - Thrombin/*antagonists & inhibitors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Bivalirudin
OT  - Direct thrombin inhibitors
OT  - Fibrinolysis
OT  - Primary percutaneous coronary intervention (primary PCI)
OT  - ST elevation myocardial infarction (STEMI)
OT  - Unfractionated heparin (UFH)
EDAT- 2017/06/06 06:00
MHDA- 2018/10/20 06:00
CRDT- 2017/06/06 06:00
PHST- 2017/06/06 06:00 [entrez]
PHST- 2017/06/06 06:00 [pubmed]
PHST- 2018/10/20 06:00 [medline]
AID - S2211-7458(16)30063-3 [pii]
AID - 10.1016/j.iccl.2016.06.008 [doi]
PST - ppublish
SO  - Interv Cardiol Clin. 2016 Oct;5(4):497-511. doi: 10.1016/j.iccl.2016.06.008. Epub 
      2016 Aug 10.