PMID- 28584104
OWN - NLM
STAT- MEDLINE
DCOM- 20180503
LR  - 20211204
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 114
IP  - 25
DP  - 2017 Jun 20
TI  - Phosphorylation and negative regulation of CONSTITUTIVELY PHOTOMORPHOGENIC 1 by 
      PINOID in Arabidopsis.
PG  - 6617-6622
LID - 10.1073/pnas.1702984114 [doi]
AB  - CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) plays crucial roles in various cellular 
      processes via its E3 ubiquitin ligase activity in organisms, ranging from fungi 
      to humans. As a key component in regulating various biological events, COP1 
      itself is precisely controlled at multiple layers. Here, we report a negative 
      regulator of COP1, PINOID (PID), which positively mediates photomorphogenic 
      development. Specifically, PID genetically and physically interacts with COP1 and 
      directly phosphorylates COP1 at Ser20. As a result, this posttranslational 
      modification serves to repress COP1 activity and promote photomorphogenesis. Our 
      findings signify a key regulatory mechanism for precisely maintaining COP1 
      activity, thereby ensuring appropriate development in plants.
FAU - Lin, Fang
AU  - Lin F
AD  - Department of Biology, Southern University of Science and Technology, Shenzhen 
      518055, China.
AD  - State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center 
      for Life Sciences, School of Advanced Agriculture Sciences and School of Life 
      Sciences, Peking University, Beijing 100871, China.
FAU - Xu, Dongqing
AU  - Xu D
AD  - Department of Biology, Southern University of Science and Technology, Shenzhen 
      518055, China; deng@sustc.edu.cn xudq@sustc.edu.cn.
FAU - Jiang, Yan
AU  - Jiang Y
AD  - Department of Biology, Southern University of Science and Technology, Shenzhen 
      518055, China.
AD  - State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center 
      for Life Sciences, School of Advanced Agriculture Sciences and School of Life 
      Sciences, Peking University, Beijing 100871, China.
FAU - Chen, Haodong
AU  - Chen H
AD  - State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center 
      for Life Sciences, School of Advanced Agriculture Sciences and School of Life 
      Sciences, Peking University, Beijing 100871, China.
FAU - Fan, Liumin
AU  - Fan L
AD  - State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center 
      for Life Sciences, School of Advanced Agriculture Sciences and School of Life 
      Sciences, Peking University, Beijing 100871, China.
FAU - Holm, Magnus
AU  - Holm M
AD  - Department of Biological and Environmental Sciences, Gothenburg University, 
      SE-405 30 Gothenburg, Sweden.
FAU - Deng, Xing Wang
AU  - Deng XW
AD  - Department of Biology, Southern University of Science and Technology, Shenzhen 
      518055, China; deng@sustc.edu.cn xudq@sustc.edu.cn.
AD  - State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center 
      for Life Sciences, School of Advanced Agriculture Sciences and School of Life 
      Sciences, Peking University, Beijing 100871, China.
LA  - eng
GR  - R01 GM047850/GM/NIGMS NIH HHS/United States
GR  - R37 GM047850/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20170605
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Arabidopsis Proteins)
RN  - EC 2.3.2.27 (AT2G32950 protein, Arabidopsis)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
RN  - EC 2.7.1.- (PINOID protein, Arabidopsis)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
CIN - Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8136-E8137. PMID: 28912351
CIN - Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8134-E8135. PMID: 28912352
MH  - Arabidopsis/*metabolism
MH  - Arabidopsis Proteins/*metabolism
MH  - Gene Expression Regulation, Plant/physiology
MH  - Light
MH  - Phosphorylation/*physiology
MH  - Protein Binding/physiology
MH  - Protein Processing, Post-Translational/physiology
MH  - Protein Serine-Threonine Kinases/*metabolism
MH  - Ubiquitin-Protein Ligases/*metabolism
MH  - Ubiquitination/physiology
PMC - PMC5488946
OTO - NOTNLM
OT  - Arabidopsis
OT  - COP1
OT  - PID
OT  - phosphorylation
OT  - photomorphogenesis
COIS- The authors declare no conflict of interest.
EDAT- 2017/06/07 06:00
MHDA- 2018/05/04 06:00
PMCR- 2017/12/20
CRDT- 2017/06/07 06:00
PHST- 2017/06/07 06:00 [pubmed]
PHST- 2018/05/04 06:00 [medline]
PHST- 2017/06/07 06:00 [entrez]
PHST- 2017/12/20 00:00 [pmc-release]
AID - 1702984114 [pii]
AID - 201702984 [pii]
AID - 10.1073/pnas.1702984114 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6617-6622. doi: 
      10.1073/pnas.1702984114. Epub 2017 Jun 5.