PMID- 28584318
OWN - NLM
STAT- MEDLINE
DCOM- 20180312
LR  - 20180312
IS  - 1896-494X (Electronic)
IS  - 1232-1087 (Linking)
VI  - 30
IP  - 4
DP  - 2017 Jun 19
TI  - Albumin adducts and urinary metabolites resulting from occupational exposure to 
      1,5-naphthalene diisocyanate.
PG  - 579-591
LID - 62649 [pii]
LID - 10.13075/ijomeh.1896.00863 [doi]
AB  - OBJECTIVES: 1,5-Naphthalene diisocyanate (NDI) is used in the plastic industry as 
      a curing agent. 1,5-Naphthalene diisocyanate is classified as a sensitizing 
      agent. The objective of this study has been to develop biomonitoring methods for 
      the evaluation of exposure to NDI. MATERIAL AND METHODS: We obtained blood and 
      urine samples from a group of 20 male workers exposed to NDI. The workers 
      answered a questionnaire about their exposure history, job description, the 
      number of years with the company and the time spent working with NDI over the 10 
      days of the study. Total plasma, albumin, and urine were analyzed for the 
      presence of 1,5-naphthalenediamine (NDA) after acid hydrolysis using gas 
      chromatography-mass spectrometry (GC-MS). RESULTS: 1,5-Naphthalenediamine was 
      found in about 60% of the samples obtained from the workers. 
      1,5-Naphthalenediamine was obtained after acid hydrolysis of plasma, albumin, and 
      urine at levels up to 1.5 pmol NDA/mg of plasma proteins, 1.15 pmol NDA/mg of 
      albumin, and 55.3 pmol NDA/ml of urine, respectively. CONCLUSIONS: 
      1,5-Naphthalenediamine found in urine correlates best with the plasma levels (r = 
      0.91, p < 0.01). The albumin-adduct levels did not correlate with the 
      NDI-specific immunoglobulin E (IgE) or total IgE present in the workers. The 
      adduct and metabolite levels correlate with the air levels of NDI. Int J Occup 
      Med Environ Health 2017;30(4):579-591.
CI  - This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL 
      license.
FAU - Sepai, Ovnair
AU  - Sepai O
AD  - University of Wurzburg, Wurzburg, Germany (Department of Toxicology). 
      Ovnair.Sepai@phe.gov.uk.
FAU - Sabbioni, Gabriele
AU  - Sabbioni G
AD  - University of Wurzburg, Wurzburg, Germany (Department of Toxicology). 
      gabriele.sabbioni@bluewin.ch.
LA  - eng
PT  - Journal Article
DEP - 20170420
PL  - Poland
TA  - Int J Occup Med Environ Health
JT  - International journal of occupational medicine and environmental health
JID - 9437093
RN  - 0 (Albumins)
RN  - 0 (Biomarkers)
RN  - 0 (Isocyanates)
RN  - 2243-62-1 (1,5-naphthalenediamine)
RN  - 3173-72-6 (1,5-naphthylene di-isocyanate)
RN  - 9753I242R5 (1-Naphthylamine)
SB  - IM
MH  - 1-Naphthylamine/*analogs & derivatives/analysis
MH  - Adult
MH  - Albumins/chemistry
MH  - Biomarkers/blood/urine
MH  - Environmental Monitoring/methods
MH  - Humans
MH  - Isocyanates/*analysis/blood/urine
MH  - Male
MH  - Middle Aged
MH  - Occupational Exposure/*analysis
OTO - NOTNLM
OT  - albumin adducts
OT  - arylamine
OT  - biomonitoring
OT  - diisocyanates
OT  - occupational hygiene
OT  - urinary metabolites
EDAT- 2017/06/07 06:00
MHDA- 2018/03/13 06:00
CRDT- 2017/06/07 06:00
PHST- 2017/06/07 06:00 [pubmed]
PHST- 2018/03/13 06:00 [medline]
PHST- 2017/06/07 06:00 [entrez]
AID - 62649 [pii]
AID - 10.13075/ijomeh.1896.00863 [doi]
PST - ppublish
SO  - Int J Occup Med Environ Health. 2017 Jun 19;30(4):579-591. doi: 
      10.13075/ijomeh.1896.00863. Epub 2017 Apr 20.