PMID- 28584599
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1999-768X (Print)
IS  - 2070-5204 (Electronic)
IS  - 1999-768X (Linking)
VI  - 32
IP  - 3
DP  - 2017 May
TI  - The Role of Insulin Therapy in Correcting Hepcidin Levels in Patients with Type 2 
      Diabetes Mellitus.
PG  - 195-200
LID - 10.5001/omj.2017.37 [doi]
AB  - OBJECTIVES: Iron overload can cause or contribute to the pathogenesis of type 2 
      diabetes mellitus (T2DM), but how the major parameters of iron metabolism change 
      in different settings of diabetes are still unclear. The aim of this study was to 
      determine the relationship between iron, ferritin, and hepcidin levels in 
      diabetic patients and the effect of insulin treatment. METHODS: The study 
      included 80 subjects, 60 with T2DM and 20 without (control group). Serum 
      hepcidin, insulin, ferritin, and iron levels were determined as well as other 
      clinical parameters. The associations between these parameters were analyzed 
      between both groups. RESULTS: Hepcidin levels expressed as mean+/- standard 
      deviation between groups showed no significant changes (14.4+/-6.7 ng/mL for the 
      control group, and 18.4+/-7.9 ng/mL for patients with diabetes, p = 0.069). 
      Parameters of iron metabolism showed modest correlation with the parameters of 
      glucose metabolism. However, the correlation between ferritin and insulin in both 
      groups was statistically significant (p = 0.032; rho = 0.480 vs. p = 0.011; rho = 
      0.328). CONCLUSIONS: Our study showed that hepcidin levels in patients with T2DM 
      on insulin therapy do not change, which might be a result of treatment with 
      insulin. In this context, insulin treatment can be used as a novel method for 
      correction of hepcidin levels. By correcting hepcidin levels, we can prevent 
      cellular iron overload and reduce the risk of diabetes.
FAU - Vela, Driton
AU  - Vela D
AD  - Faculty of Medicine, University of Prishtina, Prishtina, Kosovo.
FAU - Leshoski, Jovica
AU  - Leshoski J
AD  - Institute of Biology, Faculty of Natural Sciences, Saints Cyril and Methodius 
      University of Skopje, Skopje, Macedonia.
FAU - Gjorgievska, Elizabeta S
AU  - Gjorgievska ES
AD  - Faculty of Dental Medicine, Saints Cyril and Methodius University of Skopje, 
      Skopje, Macedonia.
FAU - Hadzi-Petrushev, Nikola
AU  - Hadzi-Petrushev N
AD  - Institute of Biology, Faculty of Natural Sciences, Saints Cyril and Methodius 
      University of Skopje, Skopje, Macedonia.
FAU - Jakupaj, Muharrem
AU  - Jakupaj M
AD  - Faculty of Medicine, University of Prishtina, Prishtina, Kosovo.
FAU - Sopi, Ramadan B
AU  - Sopi RB
AD  - Faculty of Medicine, University of Prishtina, Prishtina, Kosovo.
FAU - Mladenov, Mitko
AU  - Mladenov M
AD  - Institute of Biology, Faculty of Natural Sciences, Saints Cyril and Methodius 
      University of Skopje, Skopje, Macedonia.
LA  - eng
PT  - Journal Article
PL  - Oman
TA  - Oman Med J
JT  - Oman medical journal
JID - 101526350
PMC - PMC5447797
OTO - NOTNLM
OT  - Ferritin
OT  - Hepcidin
OT  - Insulin
EDAT- 2017/06/07 06:00
MHDA- 2017/06/07 06:01
PMCR- 2017/05/01
CRDT- 2017/06/07 06:00
PHST- 2017/06/07 06:00 [entrez]
PHST- 2017/06/07 06:00 [pubmed]
PHST- 2017/06/07 06:01 [medline]
PHST- 2017/05/01 00:00 [pmc-release]
AID - OMJ-D-16-00115 [pii]
AID - 10.5001/omj.2017.37 [doi]
PST - ppublish
SO  - Oman Med J. 2017 May;32(3):195-200. doi: 10.5001/omj.2017.37.