PMID- 28584630
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220316
IS  - 2049-9434 (Print)
IS  - 2049-9442 (Electronic)
IS  - 2049-9434 (Linking)
VI  - 6
IP  - 6
DP  - 2017 Jun
TI  - Connexin 43: Key roles in the skin.
PG  - 605-611
LID - 10.3892/br.2017.903 [doi]
AB  - Gap junctions are tightly packed intercellular channels that serve a common 
      purpose of allowing the intercellular exchange of small metabolites, second 
      messengers and electrical signals. Connexins (Cxs) are gap junction proteins. 
      Currently, 20 and 21 members of Cxs have been characterized in mice and humans, 
      respectively. Connexin 43 (Cx43) is the most ubiquitously expressed type of Cx in 
      the skin. It is produced by various different types of skin cell, such as 
      keratinocytes, fibroblasts, endothelial and basal cells, melanocytes and dermal 
      papilla cells. At present, more evidence indicates that Cx43 has an important 
      role in skin repair and skin tumor development, as well as in skin cell invasion 
      and metastasis. In this review, current knowledge regarding the regulation and 
      function of Cx43 is summarized and the therapeutic potential of regulating Cx43 
      activity is discussed.
FAU - Zhang, Xiao-Fei
AU  - Zhang XF
AD  - Department of Biological Sciences and Biotechnology, School of Chemistry, 
      Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 
      Hubei 430070, P.R. China.
FAU - Cui, Xiaofeng
AU  - Cui X
AD  - Department of Biological Sciences and Biotechnology, School of Chemistry, 
      Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 
      Hubei 430070, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170503
PL  - England
TA  - Biomed Rep
JT  - Biomedical reports
JID - 101613227
PMC - PMC5449964
OTO - NOTNLM
OT  - connexin 43
OT  - gap junction
OT  - mimetic peptides
OT  - skin diseases
OT  - wound healing
EDAT- 2017/06/07 06:00
MHDA- 2017/06/07 06:01
PMCR- 2017/05/03
CRDT- 2017/06/07 06:00
PHST- 2016/11/21 00:00 [received]
PHST- 2017/03/17 00:00 [accepted]
PHST- 2017/06/07 06:00 [entrez]
PHST- 2017/06/07 06:00 [pubmed]
PHST- 2017/06/07 06:01 [medline]
PHST- 2017/05/03 00:00 [pmc-release]
AID - BR-0-0-903 [pii]
AID - 10.3892/br.2017.903 [doi]
PST - ppublish
SO  - Biomed Rep. 2017 Jun;6(6):605-611. doi: 10.3892/br.2017.903. Epub 2017 May 3.