PMID- 28584720
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2167-8359 (Print)
IS  - 2167-8359 (Electronic)
IS  - 2167-8359 (Linking)
VI  - 5
DP  - 2017
TI  - Clinical impact of human papillomavirus in laryngeal squamous cell carcinoma: a 
      retrospective study.
PG  - e3395
LID - 10.7717/peerj.3395 [doi]
LID - e3395
AB  - OBJECTIVES: The purpose of this study is to determine the prevalence and clinical 
      impact of human papillomavirus (HPV) related laryngeal squamous cell carcinoma 
      (LSCC). METHODS: A total of 106 LSCC patients who underwent primary surgical 
      resection with or without adjuvant radiotherapy/chemoradiotherapy were enrolled 
      retrospectively. Tumors collected from paraffin-embedded samples were used for 
      HPV detection by polymerase chain reaction and in situ hybridization technique. 
      Clinicopathological parameters were recorded for analysis. RESULTS: The 
      prevalence of HPV in patients with LSCC was 13.2% in our series and 12 out of 14 
      (85.7%) HPV-positive tumors were HPV-16. The patients with HPV-positive tumors 
      were older (p = 0.042), less local/regional recurrence (p = 0.037) and non-smoker 
      (p = 0.068). There was no significant difference in the 5-year overall survival 
      (OS) (p = 0.8056) between HPV-positive and -negative tumors. The patients with 
      HPV-positive tumors had a better 5-year disease-specific survival (DSS) (100% vs. 
      84.8%, p = 0.1485), although the difference did not reach statistical 
      significance. However, the local/regional control rate was significantly better 
      in HPV-positive tumors than in HPV-negative tumors (100% vs. 75%, p = 0.0494). 
      CONCLUSIONS: A low prevalence of HPV infection in our series suggests that HPV is 
      not a major cause of LSCC. However, a 100% local/regional control rate and DSS 
      were observed in HPV-positive tumors. This finding suggests a different tumor 
      behavior between HPV-positive and HPV-negative LSCC. Further research with a 
      larger sample size is necessary to confirm our observations.
FAU - Chen, Wei-Chih
AU  - Chen WC
AD  - Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang 
      Gung University College of Medicine, Kaohsiung, Taiwan.
AD  - Head and Neck Oncologic Group, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 
      Taiwan.
FAU - Chuang, Hui-Ching
AU  - Chuang HC
AD  - Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang 
      Gung University College of Medicine, Kaohsiung, Taiwan.
AD  - Head and Neck Oncologic Group, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 
      Taiwan.
FAU - Lin, Yu-Tsai
AU  - Lin YT
AD  - Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang 
      Gung University College of Medicine, Kaohsiung, Taiwan.
AD  - Head and Neck Oncologic Group, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 
      Taiwan.
FAU - Huang, Chao-Cheng
AU  - Huang CC
AD  - Head and Neck Oncologic Group, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 
      Taiwan.
AD  - Department of Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan.
FAU - Chien, Chih-Yen
AU  - Chien CY
AD  - Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang 
      Gung University College of Medicine, Kaohsiung, Taiwan.
AD  - Head and Neck Oncologic Group, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 
      Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20170530
PL  - United States
TA  - PeerJ
JT  - PeerJ
JID - 101603425
PMC - PMC5452968
OTO - NOTNLM
OT  - HPV
OT  - Laryngeal cancer
OT  - Prevalence
OT  - Recurrence
OT  - Survival
COIS- The authors declare there are no competing interests.
EDAT- 2017/06/07 06:00
MHDA- 2017/06/07 06:01
PMCR- 2017/05/30
CRDT- 2017/06/07 06:00
PHST- 2017/03/09 00:00 [received]
PHST- 2017/05/09 00:00 [accepted]
PHST- 2017/06/07 06:00 [entrez]
PHST- 2017/06/07 06:00 [pubmed]
PHST- 2017/06/07 06:01 [medline]
PHST- 2017/05/30 00:00 [pmc-release]
AID - 3395 [pii]
AID - 10.7717/peerj.3395 [doi]
PST - epublish
SO  - PeerJ. 2017 May 30;5:e3395. doi: 10.7717/peerj.3395. eCollection 2017.