PMID- 28584850
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2328-8957 (Print)
IS  - 2328-8957 (Electronic)
IS  - 2328-8957 (Linking)
VI  - 4
IP  - 2
DP  - 2017 Spring
TI  - A Subset of Extreme Human Immunodeficiency Virus (HIV) Controllers Is 
      Characterized by a Small HIV Blood Reservoir and a Weak T-Cell Activation Level.
PG  - ofx064
LID - 10.1093/ofid/ofx064 [doi]
LID - ofx064
AB  - BACKGROUND: Human immunodeficiency virus controllers (HICs) form a heterogeneous 
      group of patients with regard to formal definitions, immunologic characteristics, 
      and changes over time in viral load. PATIENTS AND METHODS: The HICs with 
      undetectable viral load ([uHICs] ie, for whom a viral load had never been 
      detected with routine assays; n = 52) were compared with 178 HICs with blips 
      during the follow up (bHICs). Clinical characteristics, ultrasensitive 
      HIV-ribonucleic acid (RNA) and HIV-deoxyribonucleic acid (DNA) loads, 
      HIV1-Western blot profiles, and immune parameters were analyzed. RESULTS: 
      Relative to bHICs, uHICs had significantly lower ultrasensitive plasma HIV-RNA 
      loads (P < .0001) and HIV-DNA levels in peripheral blood mononuclear cells (P = 
      .0004), higher CD4(+) T-cell count (P = .04) at enrollment, and lower T-cell 
      activation levels. Between diagnosis and inclusion in the cohort, the CD4(+) 
      T-cell count had not changed in uHICs but had significantly decreased in bHICs. 
      Twenty-one percent of the uHICs lacked specific anti-HIV immunoglobulin G 
      antibodies, and these individuals also had very low levels of HIV-DNA. Half of 
      the uHICs had a protective human leukocyte antigen (HLA) allele (-B57/58/B27), a 
      weak CD8(+) T-cell response, and very small HIV-DNA reservoir. CONCLUSIONS: We 
      suggest that an interesting HIC phenotype combines protective HLA alleles, low 
      level of HIV blood reservoirs, and reduced immune activation. Prospective studies 
      aimed at evaluating the benefit of combined antiretroviral therapy in HICs might 
      take into account the identification of uHICs and bHICs.
CI  - (c) The Author 2017. Published by Oxford University Press on behalf of Infectious 
      Diseases Society of America.
FAU - Canoui, Etienne
AU  - Canoui E
AD  - Assistance Publique-Hopitaux de Paris (AP-HP), Service de Medecine Interne et 
      Immunologie Clinique, Groupe Hospitalier Universitaire Paris Sud, Hopital 
      Bicetre, Le Kremlin-Bicetre, France.
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM) Unite Mixte de 
      Recherche 1184, Immunologie des Maladies Virales et Autoimmunes, Universite Paris 
      Sud, Le Kremlin-Bicetre, France.
AD  - Commissariat a l'Energie Atomique et aux Energies Alternatives (CEA), Direction 
      des sciences du vivant/Institut des maladies emergentes et des therapies 
      innovantes (DSV/iMETI), Division of Immuno-Virology, Infectious Disease Models 
      and Innovative Therapies (IDMIT), France.
AD  - Universite Paris Sud, Le Kremlin-Bicetre, France.
FAU - Lecuroux, Camille
AU  - Lecuroux C
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM) Unite Mixte de 
      Recherche 1184, Immunologie des Maladies Virales et Autoimmunes, Universite Paris 
      Sud, Le Kremlin-Bicetre, France.
AD  - Commissariat a l'Energie Atomique et aux Energies Alternatives (CEA), Direction 
      des sciences du vivant/Institut des maladies emergentes et des therapies 
      innovantes (DSV/iMETI), Division of Immuno-Virology, Infectious Disease Models 
      and Innovative Therapies (IDMIT), France.
AD  - Universite Paris Sud, Le Kremlin-Bicetre, France.
FAU - Avettand-Fenoel, Veronique
AU  - Avettand-Fenoel V
AD  - Universite Paris Descartes, Sorbonne Paris Cite, Faculte de Medecine, EA 7327 
      Paris, France AP-HP, Laboratoire de Virologie, Hopital Necker-Enfants Malades, 
      Paris, France.
FAU - Gousset, Marine
AU  - Gousset M
AD  - Universite Paris Descartes, Sorbonne Paris Cite, Faculte de Medecine, EA 7327 
      Paris, France AP-HP, Laboratoire de Virologie, Hopital Necker-Enfants Malades, 
      Paris, France.
FAU - Rouzioux, Christine
AU  - Rouzioux C
AD  - Universite Paris Descartes, Sorbonne Paris Cite, Faculte de Medecine, EA 7327 
      Paris, France AP-HP, Laboratoire de Virologie, Hopital Necker-Enfants Malades, 
      Paris, France.
FAU - Saez-Cirion, Asier
AU  - Saez-Cirion A
AD  - Institut Pasteur, Unite HIV Inflammation et Persistance, Paris, France.
FAU - Meyer, Laurence
AU  - Meyer L
AD  - Universite Paris Sud, Le Kremlin-Bicetre, France.
AD  - INSERM CESP U1018, Centre de Recherche en Epidemiologie et Sante des Populations, 
      Le Kremlin-Bicetre, France; and.
AD  - AP-HP, Service d'Epidemiologie et de Sante Publique, Hopitaux Universitaires 
      Paris Sud, Hopital Bicetre, Le Kremlin-Bicetre, France.
FAU - Boufassa, Faroudy
AU  - Boufassa F
AD  - Universite Paris Sud, Le Kremlin-Bicetre, France.
AD  - INSERM CESP U1018, Centre de Recherche en Epidemiologie et Sante des Populations, 
      Le Kremlin-Bicetre, France; and.
FAU - Lambotte, Olivier
AU  - Lambotte O
AD  - Assistance Publique-Hopitaux de Paris (AP-HP), Service de Medecine Interne et 
      Immunologie Clinique, Groupe Hospitalier Universitaire Paris Sud, Hopital 
      Bicetre, Le Kremlin-Bicetre, France.
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM) Unite Mixte de 
      Recherche 1184, Immunologie des Maladies Virales et Autoimmunes, Universite Paris 
      Sud, Le Kremlin-Bicetre, France.
AD  - Commissariat a l'Energie Atomique et aux Energies Alternatives (CEA), Direction 
      des sciences du vivant/Institut des maladies emergentes et des therapies 
      innovantes (DSV/iMETI), Division of Immuno-Virology, Infectious Disease Models 
      and Innovative Therapies (IDMIT), France.
AD  - Universite Paris Sud, Le Kremlin-Bicetre, France.
FAU - Noel, Nicolas
AU  - Noel N
AD  - Assistance Publique-Hopitaux de Paris (AP-HP), Service de Medecine Interne et 
      Immunologie Clinique, Groupe Hospitalier Universitaire Paris Sud, Hopital 
      Bicetre, Le Kremlin-Bicetre, France.
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM) Unite Mixte de 
      Recherche 1184, Immunologie des Maladies Virales et Autoimmunes, Universite Paris 
      Sud, Le Kremlin-Bicetre, France.
AD  - Commissariat a l'Energie Atomique et aux Energies Alternatives (CEA), Direction 
      des sciences du vivant/Institut des maladies emergentes et des therapies 
      innovantes (DSV/iMETI), Division of Immuno-Virology, Infectious Disease Models 
      and Innovative Therapies (IDMIT), France.
AD  - Universite Paris Sud, Le Kremlin-Bicetre, France.
CN  - and the ANRS CO21 CODEX Study Group
LA  - eng
PT  - Journal Article
DEP - 20170403
PL  - United States
TA  - Open Forum Infect Dis
JT  - Open forum infectious diseases
JID - 101637045
PMC - PMC5450900
OTO - NOTNLM
OT  - HIV controllers
OT  - HIV-DNA in PBMC
OT  - HLA
OT  - immune activation
OT  - ultrasensitive plasma HIV-RNA load.
EDAT- 2017/06/07 06:00
MHDA- 2017/06/07 06:01
PMCR- 2017/04/03
CRDT- 2017/06/07 06:00
PHST- 2017/02/08 00:00 [received]
PHST- 2017/03/30 00:00 [accepted]
PHST- 2017/06/07 06:00 [entrez]
PHST- 2017/06/07 06:00 [pubmed]
PHST- 2017/06/07 06:01 [medline]
PHST- 2017/04/03 00:00 [pmc-release]
AID - ofx064 [pii]
AID - 10.1093/ofid/ofx064 [doi]
PST - epublish
SO  - Open Forum Infect Dis. 2017 Apr 3;4(2):ofx064. doi: 10.1093/ofid/ofx064. 
      eCollection 2017 Spring.