PMID- 28585128
OWN - NLM
STAT- MEDLINE
DCOM- 20180316
LR  - 20181113
IS  - 1993-1352 (Electronic)
IS  - 1672-0733 (Linking)
VI  - 37
IP  - 3
DP  - 2017 Jun
TI  - Expression of IL-17 and syndecan-1 in nasal polyps and their correlation with 
      nasal polyps.
PG  - 412-418
LID - 10.1007/s11596-017-1749-1 [doi]
AB  - Nasal polyp (NP) is a common chronic inflammatory disease of the nasal cavity and 
      sinuses. Although some authors have suggested that NP is related to inflammatory 
      factors such as interleukin (IL)-1beta, IL-5, IL-8, granulocyte-macrophage 
      colony-stimulating factor (GM-CSF), tumor necrosis factor (TNF)-alpha, and IL-17, the 
      mechanisms underlying the pathogenesis and progression of NP remain obscure. This 
      study investigated the expression and distribution of IL-17 and syndecan-1 in NP, 
      and explored the roles of these two molecules in the pathogenesis of eosinophilic 
      chronic rhinosinusitis with nasal polyps (Eos CRSwNP) and non-Eos CRSwNP. 
      Real-time PCR and immunohistochemistry were used to detect the expression of 
      IL-17 and syndecan-1 in samples [NP, unciform process (UP) from patients with 
      CRS, and middle turbinate (MT) from healthy controls undergoing pituitary tumor 
      surgery]. The results showed that the expression levels of IL-17 and syndecan-1 
      were upregulated in both NP and UP tissues, but both factors were higher in NP 
      tissues than in UP tissues. There was no significant difference in IL-17 levels 
      between the Eos CRSwNP and non-Eos CRSwNP samples, and syndecan-1 levels were 
      increased in the non-Eos CRSwNP tissues as compared with those in Eos CRSwNP 
      tissues. In all of the groups, there was a close correlation between the 
      expression of IL-17 and syndecan-1 in nasal mucosa epithelial cells, glandular 
      epithelial cells, and inflammatory cells, suggesting that IL-17 and syndecan-1 
      may play a role, and interact with each other, in the pathogenesis of non-Eos 
      CRSwNP.
FAU - Gong, Guo-Qing
AU  - Gong GQ
AD  - Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Ren, Fang-Fang
AU  - Ren FF
AD  - Department of Otolaryngology, The Fifth Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, 450052, China.
FAU - Wang, Yan-Jun
AU  - Wang YJ
AD  - Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Wan, Lang
AU  - Wan L
AD  - Department of Otolarygology, Huangshi Central Hospital, Huangshi, 435000, China.
FAU - Chen, Shan
AU  - Chen S
AD  - Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Yuan, Jie
AU  - Yuan J
AD  - Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Yang, Chuan-Mei
AU  - Yang CM
AD  - Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Liu, Bang-Hua
AU  - Liu BH
AD  - Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China. 
      liubanghuaxhyy@163.com.
FAU - Kong, Wei-Jia
AU  - Kong WJ
AD  - Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China. 
      entwjkong@hust.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170606
PL  - China
TA  - J Huazhong Univ Sci Technolog Med Sci
JT  - Journal of Huazhong University of Science and Technology. Medical sciences = Hua 
      zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. 
      Yixue Yingdewen ban
JID - 101169627
RN  - 0 (Interleukin-17)
RN  - 0 (SDC1 protein, human)
RN  - 0 (Syndecan-1)
SB  - IM
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - Eosinophilia/*genetics/immunology/pathology
MH  - Epithelial Cells/immunology/pathology
MH  - Gene Expression Regulation
MH  - Humans
MH  - Interleukin-17/*genetics/immunology
MH  - Nasal Cavity/immunology/pathology
MH  - Nasal Mucosa/immunology/pathology
MH  - Nasal Polyps/complications/*genetics/immunology/pathology
MH  - Rhinitis/complications/*genetics/immunology/pathology
MH  - Sinusitis/complications/*genetics/immunology/pathology
MH  - Syndecan-1/*genetics/immunology
OTO - NOTNLM
OT  - interleukin-17
OT  - nasal polyps
OT  - syndecan-1
EDAT- 2017/06/07 06:00
MHDA- 2018/03/17 06:00
CRDT- 2017/06/07 06:00
PHST- 2017/01/24 00:00 [received]
PHST- 2017/04/25 00:00 [revised]
PHST- 2017/06/07 06:00 [entrez]
PHST- 2017/06/07 06:00 [pubmed]
PHST- 2018/03/17 06:00 [medline]
AID - 10.1007/s11596-017-1749-1 [pii]
AID - 10.1007/s11596-017-1749-1 [doi]
PST - ppublish
SO  - J Huazhong Univ Sci Technolog Med Sci. 2017 Jun;37(3):412-418. doi: 
      10.1007/s11596-017-1749-1. Epub 2017 Jun 6.