PMID- 28585196
OWN - NLM
STAT- MEDLINE
DCOM- 20170912
LR  - 20170912
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 960
DP  - 2017
TI  - Obesity, Persistent Organic Pollutants and Related Health Problems.
PG  - 81-110
LID - 10.1007/978-3-319-48382-5_4 [doi]
AB  - The present review aims to delve into persistent organic pollutants (POPs) , as 
      xenobiotics, in correlation to human health. POPs exhibit a group of common 
      characteristics, including lipophilicity, persistence to decomposition and 
      bioaccumulation in tissues. POPs have been thoroughly studied by former 
      researchers, as they offer a particular interest in the elucidation of metabolic, 
      endocrine and immune perturbation caused by their synergy with intracellular 
      mechanisms. Herein particular focus is attributed to the relationship of POPs 
      with obesity provocation. Obesity nowadays receives epidemic dimensions, as its 
      prevalence elevates in an exponential degree. POPs-induced obesity rotates around 
      interfering in metabolic and endocrinal procedures and interacting with 
      peroxisome-proliferator and retinoic receptors. Moreover, polymorphisms in CYP 
      gene families exert a negative result, as they incapacitate detoxification of 
      POPs. Obesity could be deemed as a multidimensional condition, as various factors 
      interact to lead to an obesogenic result. Therefore, concomitant disorders may 
      occur, from mild to lethal, and get intensified due to POPs exposure. POPs exact 
      function mechanisms remain rather enigmatic, thus further investigation should be 
      prospectively performed, for a more lucid picture of this issue, and, 
      consequently for the establishment of alternative solutions.
FAU - Vassilopoulou, Loukia
AU  - Vassilopoulou L
AD  - Laboratory of Toxicology, Medical School, University of Crete, Voutes, 71409, 
      Heraklion, Crete, Greece.
FAU - Psycharakis, Christos
AU  - Psycharakis C
AD  - Laboratory of Toxicology, Medical School, University of Crete, Voutes, 71409, 
      Heraklion, Crete, Greece.
FAU - Petrakis, Demetrios
AU  - Petrakis D
AD  - Laboratory of Toxicology, Medical School, University of Crete, Voutes, 71409, 
      Heraklion, Crete, Greece.
FAU - Tsiaoussis, John
AU  - Tsiaoussis J
AD  - Laboratory of Anatomy, Medical School, University of Crete, Voutes, 71110, 
      Heraklion, Crete, Greece.
FAU - Tsatsakis, Aristides M
AU  - Tsatsakis AM
AD  - Department of Forensic Sciences and Toxicology, Medical School, University of 
      Crete, Voutes, 71003, Heraklion, Crete, Greece. aris@med.uoc.gr.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Environmental Pollutants)
RN  - 0 (Xenobiotics)
SB  - IM
MH  - Environmental Pollutants/*adverse effects
MH  - Humans
MH  - Obesity/*epidemiology/*etiology
MH  - Xenobiotics/*adverse effects
OTO - NOTNLM
OT  - Bioaccumulation
OT  - CYP polymorphism
OT  - Diabetes
OT  - Endocrine signaling
OT  - Metabolism
OT  - Obesity
OT  - Persistent organic pollutants
OT  - Toxicokinetics
OT  - Xenobiotics
EDAT- 2017/06/07 06:00
MHDA- 2017/09/13 06:00
CRDT- 2017/06/07 06:00
PHST- 2017/06/07 06:00 [entrez]
PHST- 2017/06/07 06:00 [pubmed]
PHST- 2017/09/13 06:00 [medline]
AID - 10.1007/978-3-319-48382-5_4 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2017;960:81-110. doi: 10.1007/978-3-319-48382-5_4.