PMID- 28586166
OWN - NLM
STAT- MEDLINE
DCOM- 20190107
LR  - 20201209
IS  - 2151-4658 (Electronic)
IS  - 2151-464X (Linking)
VI  - 70
IP  - 3
DP  - 2018 Mar
TI  - Differentiating Psoriatic Arthritis From Psoriasis Without Psoriatic Arthritis 
      Using Novel Serum Biomarkers.
PG  - 454-461
LID - 10.1002/acr.23298 [doi]
AB  - OBJECTIVE: There is a high prevalence of undiagnosed psoriatic arthritis (PsA) in 
      patients with psoriasis. Identifying soluble biomarkers for PsA will help in 
      screening psoriasis patients for appropriate rheumatology referral. We therefore 
      aimed to investigate whether serum levels of novel markers previously discovered 
      by quantitative mass spectrometric analysis of synovial fluid and skin biopsies 
      performs better than the C-reactive protein (CRP) level in differentiating PsA 
      patients from those with psoriasis without PsA (PsC). METHODS: In this 
      case-control study, serum samples were obtained from 100 subjects with PsA, 100 
      with PsC, and 100 healthy controls. Patients with PsA and PsC were group matched 
      for age, sex, psoriasis duration, and Psoriasis Area and Severity Index and were 
      not currently receiving biologic treatment. Using enzyme-linked immunosorbent 
      assay, 4 high-priority markers (Mac-2-binding protein [M2BP], CD5-like protein 
      [CD5L], myeloperoxidase [MPO], and integrin beta5 [ITGbeta5]), as well as previously 
      established markers (matrix metalloproteinase 3 [MMP-3] and CRP level) were 
      assayed. Data were analyzed using logistic regression. Receiver operating 
      characteristic (ROC) curves were plotted. RESULTS: In comparisons to controls, 
      CD5L, ITGbeta5, M2BP, MPO, MMP-3, and CRP level were independently associated with 
      PsA, while only CD5L, M2BP, and MPO were independently associated with PsC alone. 
      In comparisons to PsC, ITGbeta5, M2BP, and CRP level were independently associated 
      with PsA. ROC analysis of this model shows an area under the curve (AUC) of 0.85 
      (95% confidence interval [95% CI] 0.80-0.90). The model that included CRP level 
      alone had an AUC of 0.71 (95% CI 0.64-0.78). CONCLUSION: CD5L, ITGbeta5, M2BP, MPO, 
      MMP-3, and CRP level are markers for PsA. The combination of ITGbeta5, M2BP, and CRP 
      level differentiates PsA from PsC, and performs better than CRP level alone.
CI  - (c) 2017, American College of Rheumatology.
FAU - Cretu, Daniela
AU  - Cretu D
AD  - University of Toronto, Toronto, Ontario, Canada.
FAU - Gao, Lisa
AU  - Gao L
AD  - University of Waterloo, Waterloo, Ontario, Canada.
FAU - Liang, Kun
AU  - Liang K
AD  - University of Waterloo, Waterloo, Ontario, Canada.
FAU - Soosaipillai, Antoninus
AU  - Soosaipillai A
AD  - Mount Sinai Hospital, Toronto, Ontario, Canada.
FAU - Diamandis, Eleftherios P
AU  - Diamandis EP
AD  - Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada.
FAU - Chandran, Vinod
AU  - Chandran V
AD  - Toronto Western Hospital, Krembil Research Institute, and University of Toronto, 
      Toronto, Ontario, Canada.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arthritis Care Res (Hoboken)
JT  - Arthritis care & research
JID - 101518086
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (Biomarkers)
RN  - 0 (CD5L protein, human)
RN  - 0 (ITGB5 protein, human)
RN  - 0 (Integrin beta Chains)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Scavenger)
RN  - 0 (Scavenger Receptors, Class B)
RN  - 0 (TAA90K protein, human)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 1.11.1.7 (MPO protein, human)
RN  - EC 1.11.1.7 (Peroxidase)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Antigens, Neoplasm/blood
MH  - Apoptosis Regulatory Proteins
MH  - Arthritis, Psoriatic/*blood/*diagnosis/immunology
MH  - Biomarkers/*blood
MH  - C-Reactive Protein/analysis
MH  - Case-Control Studies
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Integrin beta Chains/blood
MH  - Male
MH  - Matrix Metalloproteinase 3/blood
MH  - Membrane Glycoproteins/blood
MH  - Middle Aged
MH  - Peroxidase/blood
MH  - Predictive Value of Tests
MH  - Psoriasis/*blood/*diagnosis/immunology
MH  - Receptors, Scavenger
MH  - Scavenger Receptors, Class B/blood
EDAT- 2017/06/07 06:00
MHDA- 2019/01/08 06:00
CRDT- 2017/06/07 06:00
PHST- 2016/12/05 00:00 [received]
PHST- 2017/06/01 00:00 [accepted]
PHST- 2017/06/07 06:00 [pubmed]
PHST- 2019/01/08 06:00 [medline]
PHST- 2017/06/07 06:00 [entrez]
AID - 10.1002/acr.23298 [doi]
PST - ppublish
SO  - Arthritis Care Res (Hoboken). 2018 Mar;70(3):454-461. doi: 10.1002/acr.23298.