PMID- 28586276
OWN - NLM
STAT- MEDLINE
DCOM- 20171005
LR  - 20240327
IS  - 1535-4989 (Electronic)
IS  - 1044-1549 (Print)
IS  - 1044-1549 (Linking)
VI  - 57
IP  - 4
DP  - 2017 Oct
TI  - Dendritic Cell Trafficking and Function in Rare Lung Diseases.
PG  - 393-402
LID - 10.1165/rcmb.2017-0051PS [doi]
AB  - Dendritic cells (DCs) are highly specialized immune cells that capture antigens 
      and then migrate to lymphoid tissue and present antigen to T cells. This critical 
      function of DCs is well defined, and recent studies further demonstrate that DCs 
      are also key regulators of several innate immune responses. Studies focused on 
      the roles of DCs in the pathogenesis of common lung diseases, such as asthma, 
      infection, and cancer, have traditionally driven our mechanistic understanding of 
      pulmonary DC biology. The emerging development of novel DC reagents, techniques, 
      and genetically modified animal models has provided abundant data revealing 
      distinct populations of DCs in the lung, and allow us to examine mechanisms of DC 
      development, migration, and function in pulmonary disease with unprecedented 
      detail. This enhanced understanding of DCs permits the examination of the 
      potential role of DCs in diseases with known or suspected immunological 
      underpinnings. Recent advances in the study of rare lung diseases, including 
      pulmonary Langerhans cell histiocytosis, sarcoidosis, hypersensitivity 
      pneumonitis, and pulmonary fibrosis, reveal expanding potential pathogenic roles 
      for DCs. Here, we provide a review of DC development, trafficking, and effector 
      functions in the lung, and discuss how alterations in these DC pathways 
      contribute to the pathogenesis of rare lung diseases.
FAU - Liu, Huan
AU  - Liu H
AD  - 1 Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep 
      Medicine, University of Cincinnati, Cincinnati, Ohio.
FAU - Jakubzick, Claudia
AU  - Jakubzick C
AD  - 2 Department of Immunology and Microbiology, National Jewish Health and 
      University of Colorado, Denver, Colorado; and.
FAU - Osterburg, Andrew R
AU  - Osterburg AR
AD  - 1 Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep 
      Medicine, University of Cincinnati, Cincinnati, Ohio.
FAU - Nelson, Rebecca L
AU  - Nelson RL
AD  - 1 Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep 
      Medicine, University of Cincinnati, Cincinnati, Ohio.
FAU - Gupta, Nishant
AU  - Gupta N
AUID- ORCID: 0000-0001-9112-1315
AD  - 1 Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep 
      Medicine, University of Cincinnati, Cincinnati, Ohio.
AD  - 3 Cincinnati Veteran's Affairs Medical Center, Cincinnati, Ohio.
FAU - McCormack, Francis X
AU  - McCormack FX
AD  - 1 Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep 
      Medicine, University of Cincinnati, Cincinnati, Ohio.
AD  - 3 Cincinnati Veteran's Affairs Medical Center, Cincinnati, Ohio.
FAU - Borchers, Michael T
AU  - Borchers MT
AD  - 1 Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep 
      Medicine, University of Cincinnati, Cincinnati, Ohio.
AD  - 3 Cincinnati Veteran's Affairs Medical Center, Cincinnati, Ohio.
LA  - eng
GR  - I01 BX002347/BX/BLRD VA/United States
GR  - R01 HL115334/HL/NHLBI NIH HHS/United States
GR  - R01 HL119538/HL/NHLBI NIH HHS/United States
GR  - U54 HL127672/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - Am J Respir Cell Mol Biol
JT  - American journal of respiratory cell and molecular biology
JID - 8917225
SB  - IM
MH  - Alveolitis, Extrinsic Allergic/*immunology/pathology/therapy
MH  - Animals
MH  - Antigen Presentation
MH  - Cell Movement/*immunology
MH  - Dendritic Cells/*immunology/pathology
MH  - Histiocytosis, Langerhans-Cell/*immunology/pathology/therapy
MH  - Humans
MH  - Pulmonary Fibrosis/*immunology/pathology/therapy
MH  - Sarcoidosis, Pulmonary/*immunology/pathology/therapy
MH  - T-Lymphocytes/immunology/pathology
PMC - PMC5650088
OTO - NOTNLM
OT  - dendritic cells
OT  - fibrosis
OT  - histiocytosis
OT  - hypersensitivity pneumonitis
OT  - sarcoidosis
EDAT- 2017/06/07 06:00
MHDA- 2017/10/06 06:00
PMCR- 2018/10/01
CRDT- 2017/06/07 06:00
PHST- 2017/06/07 06:00 [pubmed]
PHST- 2017/10/06 06:00 [medline]
PHST- 2017/06/07 06:00 [entrez]
PHST- 2018/10/01 00:00 [pmc-release]
AID - 10.1165/rcmb.2017-0051PS [doi]
PST - ppublish
SO  - Am J Respir Cell Mol Biol. 2017 Oct;57(4):393-402. doi: 10.1165/rcmb.2017-0051PS.