PMID- 28587230
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20181113
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 18
IP  - 6
DP  - 2017 Jun 5
TI  - Aronia melanocarpa (Black Chokeberry) Reduces Ethanol-Induced Gastric Damage via 
      Regulation of HSP-70, NF-kappaB, and MCP-1 Signaling.
LID - 10.3390/ijms18061195 [doi]
LID - 1195
AB  - Aronia melanocarpa (Michx.) Ell. belongs to the Rosaceae family. The purpose of 
      this study is to explore the gastroprotective effect of the Aronia melanocarpa 
      hydro-alcoholic extract (AMHAE) against ethanol-induced gastric ulcer in a rat 
      model. Different concentrations (50, 100, and 200 mg/kg) of AMHAE, or 30 mg/kg of 
      omeprazole, significantly inhibited the gastric injury formation. The 
      ethanol-induced ulcer group showed significant increases of malondialdehyde 
      (MDA), myeloperoxidase (MPO), tumor necrosis factor (TNF)-alpha, nuclear 
      factor-kappaB p65 (NF-kappaB p65), and monocyte chemoattractant protein (MCP)-1, and 
      decreased activities of superoxide dismutase (SOD), catalase (CAT), glutathione 
      peroxidase (GSH-px), and interleukin (IL)-4. However, AMHAE (200 mg/kg) 
      pretreatment significantly reversed the altered pathophysiological levels of 
      these biomolecules to near normal stages. The gastroprotective activity of AMHAE 
      was abolished by pretreatment with l-NAME, naloxone, capsazepine, and 
      indomethacin, demonstrating the participation of nitric oxide (NO), opioids, TRPV 
      (vanilloid receptor-related transient receptor potential), and prostaglandins in 
      AMHAE-assisted gastroprotection against ethanol-induced gastric injuries. This 
      gastroprotective effect of AMHAE might be due to the downregulation of 
      TNF-alpha-based NF-kappaB, MCP-1 signaling and strong antioxidant properties.
FAU - Paulrayer, Antonisamy
AU  - Paulrayer A
AD  - College of Veterinary Medicine, BK21PLUS project, Chonbuk National University, 79 
      Gobong-ro, Iksan-city, Jeollabuk-do 54596, Korea. evolutionantony@gmail.com.
FAU - Adithan, Aravinthan
AU  - Adithan A
AD  - College of Veterinary Medicine, BK21PLUS project, Chonbuk National University, 79 
      Gobong-ro, Iksan-city, Jeollabuk-do 54596, Korea. aravinthchandra@gmail.com.
FAU - Lee, Jeong Ho
AU  - Lee JH
AD  - Sunchang Reserch Institute of Health and Longevity, Ingye-myeon Indeok-ro, 
      Sunchang-gun, Jeollabuk-do 56015, Korea. wooju0717@hanmail.net.
FAU - Moon, Kwang Hyun
AU  - Moon KH
AD  - Sunchang Reserch Institute of Health and Longevity, Ingye-myeon Indeok-ro, 
      Sunchang-gun, Jeollabuk-do 56015, Korea. khmoon@korea.kr.
FAU - Kim, Dae Geun
AU  - Kim DG
AD  - Sunchang Reserch Institute of Health and Longevity, Ingye-myeon Indeok-ro, 
      Sunchang-gun, Jeollabuk-do 56015, Korea. roofdg@hanmail.net.
FAU - Im, So Yeon
AU  - Im SY
AD  - Sunchang Reserch Institute of Health and Longevity, Ingye-myeon Indeok-ro, 
      Sunchang-gun, Jeollabuk-do 56015, Korea. soyoun5005@hanmail.net.
FAU - Kang, Chang-Won
AU  - Kang CW
AD  - College of Veterinary Medicine, BK21PLUS project, Chonbuk National University, 79 
      Gobong-ro, Iksan-city, Jeollabuk-do 54596, Korea. cwkang@chonbuk.ac.kr.
FAU - Kim, Nam Soo
AU  - Kim NS
AD  - College of Veterinary Medicine, BK21PLUS project, Chonbuk National University, 79 
      Gobong-ro, Iksan-city, Jeollabuk-do 54596, Korea. namsoo@jbnu.ac.kr.
FAU - Kim, Jong-Hoon
AU  - Kim JH
AD  - College of Veterinary Medicine, BK21PLUS project, Chonbuk National University, 79 
      Gobong-ro, Iksan-city, Jeollabuk-do 54596, Korea. jhkim1@jbnu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20170605
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Chemokine CCL2)
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (NF-kappa B)
RN  - 0 (Phytochemicals)
RN  - 0 (Plant Extracts)
RN  - 0 (Protective Agents)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Animals
MH  - Anti-Ulcer Agents/chemistry/pharmacology
MH  - Chemokine CCL2/*metabolism
MH  - Chromatography, High Pressure Liquid
MH  - Disease Models, Animal
MH  - Ethanol/*adverse effects
MH  - Gastric Mucosa/drug effects/metabolism/pathology
MH  - HSP70 Heat-Shock Proteins/*metabolism
MH  - Male
MH  - NF-kappa B/*metabolism
MH  - Photinia/*chemistry
MH  - Phytochemicals/chemistry
MH  - Plant Extracts/chemistry/*pharmacology
MH  - Protective Agents/pharmacology
MH  - Rats
MH  - Signal Transduction/*drug effects
MH  - Stomach Ulcer/*chemically induced/drug therapy/*metabolism/pathology
PMC - PMC5486018
OTO - NOTNLM
OT  - Aronia melanocarpa
OT  - ethanol-induced gastric ulcer
OT  - gastroprotective activity
OT  - ulcer index
COIS- The authors declare no conflict of interest.
EDAT- 2017/06/08 06:00
MHDA- 2018/03/27 06:00
PMCR- 2017/06/01
CRDT- 2017/06/08 06:00
PHST- 2017/02/21 00:00 [received]
PHST- 2017/05/15 00:00 [revised]
PHST- 2017/05/17 00:00 [accepted]
PHST- 2017/06/08 06:00 [entrez]
PHST- 2017/06/08 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
PHST- 2017/06/01 00:00 [pmc-release]
AID - ijms18061195 [pii]
AID - ijms-18-01195 [pii]
AID - 10.3390/ijms18061195 [doi]
PST - epublish
SO  - Int J Mol Sci. 2017 Jun 5;18(6):1195. doi: 10.3390/ijms18061195.