PMID- 28587336
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 13
IP  - 6
DP  - 2017 Jun
TI  - Effects of polyvinylpyrrolidone-iodine on tendon-bone healing in a rabbit 
      extra-articular model.
PG  - 2751-2756
LID - 10.3892/etm.2017.4359 [doi]
AB  - Polyvinylpyrrolidone-iodine (PVP-I) is a broad-spectrum antimicrobial agent, but 
      its effects on tendon-bone healing are unclear. The purpose of this study was to 
      investigate the effects of PVP-I on bone marrow mesenchymal stem cells (BMSCs) in 
      vitro and on tendon-bone healing in vivo. In this study, following investigation 
      of the concentration-dependent effects of PVP-I on the viability and osteogenic 
      differentiation of BMSCs, the appropriate concentration of PVP-I was selected for 
      animal experiments. New Zealand white rabbits received autologous tendon 
      transplantation with and without PVP-I treatment of the graft tendon. 
      Subsequently, histological examination, biomechanical testing and reverse 
      transcription-quantitative polymerase chain reaction (RT-qPCR) analyses were 
      conducted. At 6 weeks post-surgery, connective tissue and osteogenesis was 
      observed at the tendon-bone interface in the PVP-I group. At 12 weeks 
      post-surgery, the interface width in the PVP-I group was much narrower compared 
      with that of the control group. Furthermore, the biomechanical properties of the 
      PVP-I group were significantly stronger than those in the control group (P<0.05). 
      RT-qPCR examination revealed that the mRNA levels of bone morphogenetic protein-2 
      and osteopontin in the PVP-I group were higher than those in the control group at 
      6 weeks (P<0.05). In conclusion, these results indicated that PVP-I promoted 
      tendon-bone healing via osteogenesis.
FAU - Zhang, Peng
AU  - Zhang P
AD  - Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai 
      200040, P.R. China.
FAU - Zhi, Yunlong
AU  - Zhi Y
AD  - Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai 
      200040, P.R. China.
FAU - Fang, Hongwei
AU  - Fang H
AD  - Department of Anesthesiology, Bengbu Medical College, Bengbu, Anhui 233004, P.R. 
      China.
FAU - Wu, Ziying
AU  - Wu Z
AD  - Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai 
      200040, P.R. China.
FAU - Chen, Tianwu
AU  - Chen T
AD  - Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai 
      200040, P.R. China.
FAU - Jiang, Jia
AU  - Jiang J
AD  - Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai 
      200040, P.R. China.
FAU - Chen, Shiyi
AU  - Chen S
AD  - Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai 
      200040, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170419
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5450688
OTO - NOTNLM
OT  - anterior cruciate ligament
OT  - bone marrow mesenchymal stem cells
OT  - osteogenesis
OT  - polyvinylpyrrolidone-iodine
OT  - tendon-bone healing
EDAT- 2017/06/08 06:00
MHDA- 2017/06/08 06:01
PMCR- 2017/04/19
CRDT- 2017/06/08 06:00
PHST- 2016/01/25 00:00 [received]
PHST- 2017/02/17 00:00 [accepted]
PHST- 2017/06/08 06:00 [entrez]
PHST- 2017/06/08 06:00 [pubmed]
PHST- 2017/06/08 06:01 [medline]
PHST- 2017/04/19 00:00 [pmc-release]
AID - ETM-0-0-4359 [pii]
AID - 10.3892/etm.2017.4359 [doi]
PST - ppublish
SO  - Exp Ther Med. 2017 Jun;13(6):2751-2756. doi: 10.3892/etm.2017.4359. Epub 2017 Apr 
      19.