PMID- 28587741 OWN - NLM STAT- MEDLINE DCOM- 20180425 LR - 20180425 IS - 1874-1754 (Electronic) IS - 0167-5273 (Linking) VI - 243 DP - 2017 Sep 15 TI - Plasma level of big endothelin-1 predicts the prognosis in patients with hypertrophic cardiomyopathy. PG - 283-289 LID - S0167-5273(16)34319-4 [pii] LID - 10.1016/j.ijcard.2017.03.162 [doi] AB - BACKGROUND: Cardiac remodeling is one of major pathological process in hypertrophic cardiomyopathy (HCM). Endothelin-1 has been linked to cardiac remodeling. Big endothelin-1 is the precursor of endothelin-1. METHODS: A total of 245 patients with HCM were enrolled from 1999 to 2011 and partitioned to low, middle and high level groups according to their plasma big endothelin-1 levels. RESULTS: At baseline, significant associations were found between high level of big endothelin-1 and left atrium size, heart function and atrial fibrillation. Big endothelin-1 was positively correlated with N-terminal B-type natriuretic peptide (r=0.291, p<0.001) and late gadolinium enhancement (LGE) on magnetic resonance imaging (r=0.222, p=0.016). During a follow-up of 3 (range, 2-5) years, big endothelin-1 level was positively associated with the risks of all-cause mortality, cardiovascular death and progression to NYHA class 3 or 4 (p=0.020, 0.044 and 0.032, respectively). The rate of above events in the highest tertile were 18.1%, 15.7%, 24.2%, respectively. After adjusting for multiple factors related to survival and cardiac function, the significance remained in the association of big endothelin-1 with the risk of all-cause mortality (hazard ratio (HR)=4.94, 95% confidence interval (CI) 1.07-22.88; p=0.041) and progression to NYHA class 3 or 4 (HR=4.10, 95%CI 1.32-12.75, p=0.015). CONCLUSION: Our study showed that high level of plasma big endothelin-1 predicted prognosis for patients with HCM and it can be added to the marker panel in stratifying HCM patients for giving treatment priority to those at high risk. CI - Copyright (c) 2017. Published by Elsevier B.V. FAU - Wang, Yilu AU - Wang Y AD - Department of ICU, China Meitan General Hospital, Beijing, China. FAU - Tang, Yida AU - Tang Y AD - State Key Laboratory of Cardiovascular Diseases, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Zou, Yubao AU - Zou Y AD - State Key Laboratory of Cardiovascular Diseases, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Wang, Dong AU - Wang D AD - State Key Laboratory of Cardiovascular Diseases, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Zhu, Ling AU - Zhu L AD - Department of Cardiology, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China. FAU - Tian, Tao AU - Tian T AD - State Key Laboratory of Cardiovascular Diseases, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Wang, Jizheng AU - Wang J AD - Sino-German Laboratory for Molecular Medicine, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Bao, Jingru AU - Bao J AD - Center for Cardiovascular Diseases, PLA Navy General Hospital, Beijing, China. FAU - Hui, Rutai AU - Hui R AD - State Key Laboratory of Cardiovascular Diseases, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Sino-German Laboratory for Molecular Medicine, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Kang, Lianming AU - Kang L AD - State Key Laboratory of Cardiovascular Diseases, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Song, Lei AU - Song L AD - State Key Laboratory of Cardiovascular Diseases, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Sino-German Laboratory for Molecular Medicine, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. Electronic address: lsongqd@126.com. FAU - Wang, Ji AU - Wang J AD - Department of ICU, China Meitan General Hospital, Beijing, China. Electronic address: jimhanswang@126.com. LA - eng PT - Journal Article DEP - 20170420 PL - Netherlands TA - Int J Cardiol JT - International journal of cardiology JID - 8200291 RN - 0 (Biomarkers) RN - 0 (Endothelin-1) SB - IM MH - Adult MH - Biomarkers/blood MH - Cardiomyopathy, Hypertrophic/*blood/*diagnostic imaging MH - Endothelin-1/*blood MH - Female MH - Humans MH - Male MH - Middle Aged MH - Predictive Value of Tests MH - Prognosis MH - Retrospective Studies MH - Risk Factors OTO - NOTNLM OT - Biomarker OT - Endothelin-1 OT - Hypertrophic cardiomyopathy OT - Prognosis EDAT- 2017/06/08 06:00 MHDA- 2018/04/26 06:00 CRDT- 2017/06/08 06:00 PHST- 2016/12/07 00:00 [received] PHST- 2017/03/24 00:00 [revised] PHST- 2017/03/31 00:00 [accepted] PHST- 2017/06/08 06:00 [pubmed] PHST- 2018/04/26 06:00 [medline] PHST- 2017/06/08 06:00 [entrez] AID - S0167-5273(16)34319-4 [pii] AID - 10.1016/j.ijcard.2017.03.162 [doi] PST - ppublish SO - Int J Cardiol. 2017 Sep 15;243:283-289. doi: 10.1016/j.ijcard.2017.03.162. Epub 2017 Apr 20.