PMID- 28587813
OWN - NLM
STAT- MEDLINE
DCOM- 20181031
LR  - 20220409
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 192
DP  - 2018 Feb
TI  - Abnormal regional homogeneity as a potential imaging biomarker for 
      adolescent-onset schizophrenia: A resting-state fMRI study and support vector 
      machine analysis.
PG  - 179-184
LID - S0920-9964(17)30315-8 [pii]
LID - 10.1016/j.schres.2017.05.038 [doi]
AB  - OBJECTIVE: Structural and functional abnormalities have been reported in the 
      brain of patients with adolescent-onset schizophrenia (AOS). The brain regional 
      functional synchronization in patients with AOS remains unclear. METHODS: We 
      analyzed resting-state functional magnetic resonance scans in 48 drug-naive 
      patients with AOS and 31 healthy controls by using regional homogeneity (ReHo), a 
      measurement that reflects brain local functional connectivity or synchronization 
      and indicates regional integration of information processing. Then, receiver 
      operating characteristic curves and support vector machines were used to evaluate 
      the effect of abnormal regional homogeneity in differentiating patients from 
      controls. RESULTS: Patients with AOS showed significantly increased ReHo values 
      in the bilateral superior medial prefrontal cortex (MPFC) and significantly 
      decreased ReHo values in the left superior temporal gyrus (STG), right precentral 
      lobule, right inferior parietal lobule (IPL), and left paracentral lobule when 
      compared with controls. A combination of the ReHo values in bilateral superior 
      MPFC, left STG, and right IPL was able to discriminate patients from controls 
      with the sensitivity of 88.24%, specificity of 91.89%, and accuracy of 90.14%. 
      CONCLUSION: The brain regional functional synchronization abnormalities exist in 
      drug-naive patients with AOS. A combination of ReHo values in these abnormal 
      regions might serve as potential imaging biomarker to identify patients with AOS.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Wang, Shuai
AU  - Wang S
AD  - Department of Psychiatry, the Second Xiangya Hospital, Central South University, 
      Changsha, China; Mental Health Institute of the Second Xiangya Hospital, Central 
      South University, Changsha, China; National Clinical Research Center on Mental 
      Disorders, Changsha, China; National Technology Institute on Mental Disorders, 
      Changsha, China; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, 
      China.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Henan Key Laboratory of Biological Psychiatry, Henan Mental Hospital, Second 
      Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
FAU - Lv, Luxian
AU  - Lv L
AD  - Henan Key Laboratory of Biological Psychiatry, Henan Mental Hospital, Second 
      Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
FAU - Wu, Renrong
AU  - Wu R
AD  - Department of Psychiatry, the Second Xiangya Hospital, Central South University, 
      Changsha, China; Mental Health Institute of the Second Xiangya Hospital, Central 
      South University, Changsha, China; National Clinical Research Center on Mental 
      Disorders, Changsha, China; National Technology Institute on Mental Disorders, 
      Changsha, China; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, 
      China.
FAU - Fan, Xiaoduo
AU  - Fan X
AD  - UMass Memorial Medical Center, UMass Medical School, Worcester, USA.
FAU - Zhao, Jingping
AU  - Zhao J
AD  - Department of Psychiatry, the Second Xiangya Hospital, Central South University, 
      Changsha, China; Mental Health Institute of the Second Xiangya Hospital, Central 
      South University, Changsha, China; National Clinical Research Center on Mental 
      Disorders, Changsha, China; National Technology Institute on Mental Disorders, 
      Changsha, China; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, 
      China; Henan Key Laboratory of Biological Psychiatry, Henan Mental Hospital, 
      Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China. 
      Electronic address: zhaojingpingcsu@163.com.
FAU - Guo, Wenbin
AU  - Guo W
AD  - Department of Psychiatry, the Second Xiangya Hospital, Central South University, 
      Changsha, China; Mental Health Institute of the Second Xiangya Hospital, Central 
      South University, Changsha, China; National Clinical Research Center on Mental 
      Disorders, Changsha, China; National Technology Institute on Mental Disorders, 
      Changsha, China; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, 
      China. Electronic address: guowenbin76@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170603
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adolescent
MH  - Brain/*diagnostic imaging/pathology
MH  - Brain Mapping
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Neural Pathways/diagnostic imaging
MH  - ROC Curve
MH  - *Rest
MH  - Schizophrenia/*diagnostic imaging
MH  - *Support Vector Machine
OTO - NOTNLM
OT  - Adolescent-onset schizophrenia
OT  - Biomarker
OT  - Regional homogeneity
OT  - Resting-state functional magnetic resonance
OT  - Support vector machine
EDAT- 2017/06/08 06:00
MHDA- 2018/11/01 06:00
CRDT- 2017/06/08 06:00
PHST- 2016/07/13 00:00 [received]
PHST- 2017/05/04 00:00 [revised]
PHST- 2017/05/30 00:00 [accepted]
PHST- 2017/06/08 06:00 [pubmed]
PHST- 2018/11/01 06:00 [medline]
PHST- 2017/06/08 06:00 [entrez]
AID - S0920-9964(17)30315-8 [pii]
AID - 10.1016/j.schres.2017.05.038 [doi]
PST - ppublish
SO  - Schizophr Res. 2018 Feb;192:179-184. doi: 10.1016/j.schres.2017.05.038. Epub 2017 
      Jun 3.