PMID- 28588456
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1662-5129 (Print)
IS  - 1662-5129 (Electronic)
IS  - 1662-5129 (Linking)
VI  - 11
DP  - 2017
TI  - Activity Dependent Modulation of Granule Cell Survival in the Accessory Olfactory 
      Bulb at Puberty.
PG  - 44
LID - 10.3389/fnana.2017.00044 [doi]
LID - 44
AB  - The vomeronasal system (VNS) is specialized in the detection of salient chemical 
      cues triggering social and neuroendocrine responses. Such responses are not 
      always stereotyped, instead, they vary depending on age, sex, and reproductive 
      state, yet the mechanisms underlying this variability are unclear. Here, by 
      analyzing neuronal survival in the first processing nucleus of the VNS, namely 
      the accessory olfactory bulb (AOB), through multiple bromodeoxyuridine 
      birthdating protocols, we show that exposure of female mice to male soiled 
      bedding material affects the integration of newborn granule interneurons mainly 
      after puberty. This effect is induced by urine compounds produced by mature 
      males, as bedding soiled by younger males was ineffective. The granule cell 
      increase induced by mature male odor exposure is not prevented by pre-pubertal 
      ovariectomy, indicating a lesser role of circulating estrogens in this 
      plasticity. Interestingly, the intake of adult male urine-derived cues by the 
      female vomeronasal organ increases during puberty, suggesting a direct 
      correlation between sensory activity and AOB neuronal plasticity. Thus, as odor 
      exposure increases the responses of newly born cells to the experienced stimuli, 
      the addition of new GABAergic inhibitory cells to the AOB might contribute to the 
      shaping of vomeronasal processing of male cues after puberty. Consistently, only 
      after puberty, female mice are capable to discriminate individual male odors 
      through the VNS.
FAU - Oboti, Livio
AU  - Oboti L
AD  - Center for Neuroscience Research, Children's National Health System, 
      WashingtonDC, United States.
FAU - Trova, Sara
AU  - Trova S
AD  - Department of Life Sciences and Systems Biology, Neuroscience Institute Cavalieri 
      Ottolenghi, University of TorinoOrbassano, Italy.
FAU - Schellino, Roberta
AU  - Schellino R
AD  - Department of Life Sciences and Systems Biology, Neuroscience Institute Cavalieri 
      Ottolenghi, University of TorinoOrbassano, Italy.
AD  - Department of Neurosciences "Rita Levi Montalcini", University of TurinTurin, 
      Italy.
FAU - Marraudino, Marilena
AU  - Marraudino M
AD  - Department of Life Sciences and Systems Biology, Neuroscience Institute Cavalieri 
      Ottolenghi, University of TorinoOrbassano, Italy.
AD  - Department of Neurosciences "Rita Levi Montalcini", University of TurinTurin, 
      Italy.
FAU - Harris, Natalie R
AU  - Harris NR
AD  - Department of Biological Sciences, University of Maryland, Baltimore County, 
      BaltimoreMD, United States.
FAU - Abiona, Olubukola M
AU  - Abiona OM
AD  - Department of Biological Sciences, University of Maryland, Baltimore County, 
      BaltimoreMD, United States.
FAU - Stampar, Mojca
AU  - Stampar M
AD  - Research Center for Genetic Medicine, Children's National Health System, 
      WashingtonDC, United States.
FAU - Lin, Weihong
AU  - Lin W
AD  - Department of Biological Sciences, University of Maryland, Baltimore County, 
      BaltimoreMD, United States.
FAU - Peretto, Paolo
AU  - Peretto P
AD  - Department of Life Sciences and Systems Biology, Neuroscience Institute Cavalieri 
      Ottolenghi, University of TorinoOrbassano, Italy.
LA  - eng
GR  - R01 DC012831/DC/NIDCD NIH HHS/United States
PT  - Journal Article
DEP - 20170523
PL  - Switzerland
TA  - Front Neuroanat
JT  - Frontiers in neuroanatomy
JID - 101477943
PMC - PMC5440572
OTO - NOTNLM
OT  - neurogenesis
OT  - puberty
OT  - sensory adaptation
OT  - sexual signals
OT  - vomeronasal system
EDAT- 2017/06/08 06:00
MHDA- 2017/06/08 06:01
PMCR- 2017/01/01
CRDT- 2017/06/08 06:00
PHST- 2017/02/23 00:00 [received]
PHST- 2017/05/01 00:00 [accepted]
PHST- 2017/06/08 06:00 [entrez]
PHST- 2017/06/08 06:00 [pubmed]
PHST- 2017/06/08 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fnana.2017.00044 [doi]
PST - epublish
SO  - Front Neuroanat. 2017 May 23;11:44. doi: 10.3389/fnana.2017.00044. eCollection 
      2017.