PMID- 28588469
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1662-5161 (Print)
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 11
DP  - 2017
TI  - Oxytocin Increases the Perceived Value of Both Self- and Other-Owned Items and 
      Alters Medial Prefrontal Cortex Activity in an Endowment Task.
PG  - 272
LID - 10.3389/fnhum.2017.00272 [doi]
LID - 272
AB  - The neuropeptide oxytocin (OXT) can influence self-processing and may help 
      motivate us to value the attributes of others in a more self-like manner by 
      reducing medial prefrontal cortex (mPFC) responses. We do not know however 
      whether this OXT effect extends to possessions. We tend to place a higher 
      monetary value on specific objects that belong to us compared to others, known as 
      the "endowment effect". In two double-blind, between-subject placebo (PLC) 
      controlled experiments in subjects from a collectivist culture, we investigated 
      the influence of intranasal OXT on the endowment effect, with the second study 
      incorporating functional magnetic resonance imaging (fMRI). In the task, subjects 
      decided whether to buy or sell their own or others' 
      (mother/father/classmate/stranger) possessions at various prices. Both 
      experiments demonstrated an endowment effect in the self-owned condition which 
      extended to close others (mother/father) and OXT increased this for self and all 
      other-owned items. This OXT effect was associated with reduced activity in the 
      ventral mPFC (vmPFC) in the self-owned condition but increased in the 
      mother-condition. For the classmate- and stranger-owned conditions OXT increased 
      activity in the dorsal mPFC (dmPFC). Changes in vmPFC activation were associated 
      with the size of the endowment effect for self- and mother-owned items. 
      Functional connectivity between the dmPFC and ventral striatum (VStr) was reduced 
      by OXT in self- and mother-owned conditions and between vmPFC and precuneus in 
      the self-condition. Overall our results show that OXT enhances the endowment 
      effect for both self- and other-owned items in Chinese subjects. This effect is 
      associated with reduced mPFC activation in the self-condition but enhanced 
      activation in all other-conditions and involves differential actions on both 
      dorsal and ventral regions as well as functional connectivity with brain reward 
      and other self-processing regions. Overall our findings suggest that OXT 
      increases the perceived value of both self- and other-owned items by acting on 
      neural circuitry involved in self-processing and reward.
FAU - Zhao, Weihua
AU  - Zhao W
AD  - Key Laboratory for Neuroinformation, Center for Information in Medicine, School 
      of Life Science and Technology, University of Electronic Science and Technology 
      of ChinaChengdu, China.
FAU - Geng, Yayuan
AU  - Geng Y
AD  - Key Laboratory for Neuroinformation, Center for Information in Medicine, School 
      of Life Science and Technology, University of Electronic Science and Technology 
      of ChinaChengdu, China.
FAU - Luo, Lizhu
AU  - Luo L
AD  - Key Laboratory for Neuroinformation, Center for Information in Medicine, School 
      of Life Science and Technology, University of Electronic Science and Technology 
      of ChinaChengdu, China.
FAU - Zhao, Zhiying
AU  - Zhao Z
AD  - Key Laboratory for Neuroinformation, Center for Information in Medicine, School 
      of Life Science and Technology, University of Electronic Science and Technology 
      of ChinaChengdu, China.
FAU - Ma, Xiaole
AU  - Ma X
AD  - Key Laboratory for Neuroinformation, Center for Information in Medicine, School 
      of Life Science and Technology, University of Electronic Science and Technology 
      of ChinaChengdu, China.
FAU - Xu, Lei
AU  - Xu L
AD  - Key Laboratory for Neuroinformation, Center for Information in Medicine, School 
      of Life Science and Technology, University of Electronic Science and Technology 
      of ChinaChengdu, China.
FAU - Yao, Shuxia
AU  - Yao S
AD  - Key Laboratory for Neuroinformation, Center for Information in Medicine, School 
      of Life Science and Technology, University of Electronic Science and Technology 
      of ChinaChengdu, China.
FAU - Kendrick, Keith M
AU  - Kendrick KM
AD  - Key Laboratory for Neuroinformation, Center for Information in Medicine, School 
      of Life Science and Technology, University of Electronic Science and Technology 
      of ChinaChengdu, China.
LA  - eng
PT  - Journal Article
DEP - 20170523
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC5440465
OTO - NOTNLM
OT  - endowment effect
OT  - medial prefrontal cortex
OT  - oxytocin
OT  - self-processing
OT  - value
EDAT- 2017/06/08 06:00
MHDA- 2017/06/08 06:01
PMCR- 2017/01/01
CRDT- 2017/06/08 06:00
PHST- 2016/12/13 00:00 [received]
PHST- 2017/05/08 00:00 [accepted]
PHST- 2017/06/08 06:00 [entrez]
PHST- 2017/06/08 06:00 [pubmed]
PHST- 2017/06/08 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fnhum.2017.00272 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2017 May 23;11:272. doi: 10.3389/fnhum.2017.00272. 
      eCollection 2017.