PMID- 28588480
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 9
DP  - 2017
TI  - Reduced Gray Matter Volume in Patients with Type 2 Diabetes Mellitus.
PG  - 161
LID - 10.3389/fnagi.2017.00161 [doi]
LID - 161
AB  - Background and Purpose: Previous studies of voxel-based morphometry (VBM) have 
      found that patients with type 2 diabetes mellitus (T2DM) exhibit gray matter 
      alterations, but these findings are inconsistent and have not been quantitatively 
      reviewed. Therefore, the aim of this study was to conduct a quantitative 
      meta-analysis of VBM studies of patients with T2DM. Materials and Methods: The 
      seed-based d mapping method was applied to quantitatively estimate the regional 
      gray matter abnormalities in T2DM patients. We also used meta-regression to 
      explore the effects of some demographics and clinical characteristics. Results: 
      Seven studies, with 8 datasets comprising 530 participants with T2DM and 549 
      non-T2DM controls, were included. The pooled and subgroup meta-analyses found 
      that T2DM patients showed robustly reduced gray matter in the bilateral superior 
      temporal gyrus, middle temporal gyrus, medial superior frontal gyrus, insula, 
      median cingulate cortex, precuneus cortex and the left lentiform nucleus 
      extending into the parahippocampus. The meta-regression also found that the 
      percentage of female patients with T2DM was negatively associated with gray 
      matter in the right superior temporal gyrus and illness duration was negatively 
      associated with gray matter in the right middle temporal gyrus. Conclusion: This 
      meta-analysis indicates that T2DM patients have significantly and robustly 
      reduced gray matter mainly in the cortical-striatal-limbic networks, which are 
      associated with human cognition. Thereby implicating this finding in the 
      pathophysiology of cognitive impairment in T2DM patients.
FAU - Liu, Jia
AU  - Liu J
AD  - Department of Radiology, Henan Provincial People's Hospital and the People's 
      Hospital of Zhengzhou UniversityZhengzhou, China.
AD  - Department of Radiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and TechnologyWuhan, China.
FAU - Liu, Taiyuan
AU  - Liu T
AD  - Department of Radiology, Henan Provincial People's Hospital and the People's 
      Hospital of Zhengzhou UniversityZhengzhou, China.
FAU - Wang, Wenhui
AU  - Wang W
AD  - Department of Radiology, Henan Provincial People's Hospital and the People's 
      Hospital of Zhengzhou UniversityZhengzhou, China.
FAU - Ma, Lun
AU  - Ma L
AD  - Department of Radiology, Henan Provincial People's Hospital and the People's 
      Hospital of Zhengzhou UniversityZhengzhou, China.
FAU - Ma, Xiaoyue
AU  - Ma X
AD  - Department of Radiology, Henan Provincial People's Hospital and the People's 
      Hospital of Zhengzhou UniversityZhengzhou, China.
FAU - Shi, Shaojie
AU  - Shi S
AD  - Department of Radiology, Henan Provincial People's Hospital and the People's 
      Hospital of Zhengzhou UniversityZhengzhou, China.
FAU - Gong, Qiyong
AU  - Gong Q
AD  - Huaxi MR Research Center, Department of Radiology, West China Hospital of Sichuan 
      UniversityChengdu, China.
FAU - Wang, Meiyun
AU  - Wang M
AD  - Department of Radiology, Henan Provincial People's Hospital and the People's 
      Hospital of Zhengzhou UniversityZhengzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20170522
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC5439076
OTO - NOTNLM
OT  - gray matter
OT  - meta-analysis
OT  - seed-based d mapping
OT  - type 2 diabetes
OT  - voxel-based morphometry
EDAT- 2017/06/08 06:00
MHDA- 2017/06/08 06:01
PMCR- 2017/01/01
CRDT- 2017/06/08 06:00
PHST- 2017/02/05 00:00 [received]
PHST- 2017/05/08 00:00 [accepted]
PHST- 2017/06/08 06:00 [entrez]
PHST- 2017/06/08 06:00 [pubmed]
PHST- 2017/06/08 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2017.00161 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2017 May 22;9:161. doi: 10.3389/fnagi.2017.00161. 
      eCollection 2017.