PMID- 28588672
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 13
IP  - 6
DP  - 2017 Jun
TI  - ABCG1 as a potential oncogene in lung cancer.
PG  - 3189-3194
LID - 10.3892/etm.2017.4393 [doi]
AB  - ATP-binding cassette transporter G1 (ABCG1) is a member of the ABC transporter 
      family and regulates cellular cholesterol homeostasis. It has important roles in 
      cholesterol homeostasis and tumor immunity, which has, however, not been reported 
      in lung cancer. The present study showed that ABCG1 protein is upregulated in 
      lung cancer compared with adjacent normal tissues and furthermore, aberrant ABCG1 
      expression was detected in lung cancer cell lines. ABCG1 was shown to promote the 
      proliferation of HKULC4 lung cancer cells. Moreover, ABCG1 was found to regulate 
      proliferation-, apoptosis- and cancer stem cell-associated markers in HKULC4 
      cells, implying that ABCG1 has important roles not only in the regulation of 
      proliferation but also of apoptosis and cancer stem cells. A microRNA microarray 
      analysis showed that ABCG1 significantly downregulated miR-29a, -b and -c 
      expression in HKULC4 cells. Finally, it was demonstrated that ABCG1 promoted the 
      migration and invasion in HKULC4 cells. Thus, ABCG1 may be a novel therapeutic 
      target to improve the treatment of non-small cell lung cancer.
FAU - Tian, Chunyan
AU  - Tian C
AD  - Department of Health Care and Geriatrics, Yidu Central Hospital Affiliated to 
      Weifang Medical University, Qingzhou, Shandong 262500, P.R. China.
FAU - Huang, Di
AU  - Huang D
AD  - Department of Clinical Medicine, Medical School of Shandong University, Jinan, 
      Shandong 250012, P.R. China.
FAU - Yu, Yanli
AU  - Yu Y
AD  - Department of Health Care and Geriatrics, Yidu Central Hospital Affiliated to 
      Weifang Medical University, Qingzhou, Shandong 262500, P.R. China.
FAU - Zhang, Jihong
AU  - Zhang J
AD  - Department of Critical Care Medicine (ICU), Weifang People's Hospital, Weifang, 
      Shandong 261041, P.R. China.
FAU - Fang, Qingxin
AU  - Fang Q
AD  - Department of Health Care and Geriatrics, Yidu Central Hospital Affiliated to 
      Weifang Medical University, Qingzhou, Shandong 262500, P.R. China.
FAU - Xie, Chao
AU  - Xie C
AD  - The Third Department of Internal Medicine, Shandong Cancer Hospital, Jinan, 
      Shandong 250017, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170427
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5450787
OTO - NOTNLM
OT  - ATP-binding cassette transporter G1
OT  - lung cancer
OT  - microRNA
OT  - oncogene
EDAT- 2017/06/08 06:00
MHDA- 2017/06/08 06:01
PMCR- 2017/04/27
CRDT- 2017/06/08 06:00
PHST- 2015/09/18 00:00 [received]
PHST- 2016/11/18 00:00 [accepted]
PHST- 2017/06/08 06:00 [entrez]
PHST- 2017/06/08 06:00 [pubmed]
PHST- 2017/06/08 06:01 [medline]
PHST- 2017/04/27 00:00 [pmc-release]
AID - ETM-0-0-4393 [pii]
AID - 10.3892/etm.2017.4393 [doi]
PST - ppublish
SO  - Exp Ther Med. 2017 Jun;13(6):3189-3194. doi: 10.3892/etm.2017.4393. Epub 2017 Apr 
      27.