PMID- 28588675
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 13
IP  - 6
DP  - 2017 Jun
TI  - Fragmented QRS complex is a prognostic marker of microvascular reperfusion and 
      changes in LV function occur in patients with ST elevation myocardial infarction 
      who underwent primary percutaneous coronary intervention.
PG  - 3231-3238
LID - 10.3892/etm.2017.4380 [doi]
AB  - The present study aimed to investigate the in-hospital and long-term prognostic 
      value of fragmented QRS complex (fQRS) for microvascular reperfusion and changes 
      in left ventricular (LV) function in patients with ST elevation myocardial 
      infarction (STEMI) who underwent primary percutaneous coronary intervention 
      (PCI). A total of 216 patients with STEMI undergoing primary PCI were included in 
      the current study. Patients were divided into two groups based on the presence 
      (n=126) or absence (n=90) of fQRS following electrocardiograms (ECGs) on 
      admission. Following primary PCI and follow up, patients were divided into four 
      groups based on new onset, resolution, persistence and absence of fQRS. Major 
      adverse cardiac events were defined to include cardiovascular death, arrhythmia, 
      heart failure, reinfarction and target vessel revascularization. The percentage 
      of patients with heart failure and microvascular reperfusion differed 
      significantly between the fQRS(+) and fQRS(-) groups. Levels of N-terminal 
      pro-brain natriuretic peptide (NT-proBNP), Peak creatine kinase-MB (CK-MB) and 
      Troponin I levels were observed to be significantly higher in the fQRS(+) group 
      compared with the fQRS(-) group. In univariate logistic regression analysis, left 
      ventricular ejection fraction (LVEF), NT-proBNP, Troponin I, Peak CK-MB and 
      microvascular reperfusion were found to be associated with fQRS. Multivariate 
      analysis identified that LVEF, NT-proBNP, Troponin I and microvascular 
      reperfusion may be independent predictors of fQRS. The presence of fQRS was 
      demonstrated to be associated with left ventricular dysfunction at follow up 
      assessments. The presence of fQRS was not only significantly associated with 
      myocardial microvascular reperfusion and left ventricular function, but was also 
      a prognostic marker in STEMI.
FAU - Zhang, Ruoxi
AU  - Zhang R
AD  - Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical 
      University, Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 
      Harbin, Heilongjiang 150086, P.R. China.
FAU - Chen, Shuyuan
AU  - Chen S
AD  - Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical 
      University, Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 
      Harbin, Heilongjiang 150086, P.R. China.
FAU - Zhao, Qi
AU  - Zhao Q
AD  - Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical 
      University, Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 
      Harbin, Heilongjiang 150086, P.R. China.
FAU - Sun, Meng
AU  - Sun M
AD  - Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical 
      University, Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 
      Harbin, Heilongjiang 150086, P.R. China.
FAU - Yu, Bo
AU  - Yu B
AD  - Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical 
      University, Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 
      Harbin, Heilongjiang 150086, P.R. China.
FAU - Hou, Jingbo
AU  - Hou J
AD  - Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical 
      University, Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 
      Harbin, Heilongjiang 150086, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170425
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5450773
OTO - NOTNLM
OT  - ST elevation myocardial infarction
OT  - fragmented QRS
OT  - left ventricular function
OT  - myocardial microvascular reperfusion
OT  - primary percutaneous coronary intervention
EDAT- 2017/06/08 06:00
MHDA- 2017/06/08 06:01
PMCR- 2017/04/25
CRDT- 2017/06/08 06:00
PHST- 2015/12/13 00:00 [received]
PHST- 2017/01/20 00:00 [accepted]
PHST- 2017/06/08 06:00 [entrez]
PHST- 2017/06/08 06:00 [pubmed]
PHST- 2017/06/08 06:01 [medline]
PHST- 2017/04/25 00:00 [pmc-release]
AID - ETM-0-0-4380 [pii]
AID - 10.3892/etm.2017.4380 [doi]
PST - ppublish
SO  - Exp Ther Med. 2017 Jun;13(6):3231-3238. doi: 10.3892/etm.2017.4380. Epub 2017 Apr 
      25.