PMID- 28588684
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 13
IP  - 6
DP  - 2017 Jun
TI  - Successful treatment of granulomatosis with polyangiitis with hydropneumothorax 
      using corticosteroids and immunosuppressant.
PG  - 3586-3590
LID - 10.3892/etm.2017.4440 [doi]
AB  - Pneumothorax and pleural effusion is a rare and serious complication of 
      granulomatosis with polyangiitis (GPA). The present study reported a case with a 
      history of sinusitis for 20 years, dry cough for three years and exacerbated 
      purulent nasal discharge and recurrent skin ulcers for two years. The patient 
      experienced sudden difficulty in breathing two months prior to presentation. Lung 
      computed tomography (CT) showed multiple bilateral lung nodules and cavitary 
      nodules as well as right hydropneumothorax. Paranasal sinus CT showed soft tissue 
      infiltration. The cytoplasmic pattern of anti-neutrophil cytoplasmic antibody 
      (c-ANCA) was positive and anti-proteinase 3 (PR3) antibodies, erythrocyte 
      sedimentation rate and C-reactive protein were elevated. After pleural drainage 
      and methylprednisolone pulse treatment, followed by cyclophosphamide and 
      cyclosporine, the patient's symptoms were ameliorated, lungs were re-expanded, 
      and c-ANCA, PR3 and inflammatory markers returned to normal levels.
FAU - Shi, Xu-Hua
AU  - Shi XH
AD  - Department of Rheumatology and Immunology, Beijing Chao-Yang Hospital, Capital 
      Medical University, Beijing 100020, P.R. China.
FAU - Zhang, Yong-Feng
AU  - Zhang YF
AD  - Department of Rheumatology and Immunology, Beijing Chao-Yang Hospital, Capital 
      Medical University, Beijing 100020, P.R. China.
FAU - Lu, Yue-Wu
AU  - Lu YW
AD  - Department of Rheumatology and Immunology, Beijing Chao-Yang Hospital, Capital 
      Medical University, Beijing 100020, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170508
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5450793
OTO - NOTNLM
OT  - Wegener's granulomatosis
OT  - corticosteroids
OT  - granulomatosis with polyangiitis
OT  - immunosuppressant
OT  - pneumothorax
OT  - therapy
EDAT- 2017/06/08 06:00
MHDA- 2017/06/08 06:01
PMCR- 2017/05/08
CRDT- 2017/06/08 06:00
PHST- 2016/02/03 00:00 [received]
PHST- 2017/02/10 00:00 [accepted]
PHST- 2017/06/08 06:00 [entrez]
PHST- 2017/06/08 06:00 [pubmed]
PHST- 2017/06/08 06:01 [medline]
PHST- 2017/05/08 00:00 [pmc-release]
AID - ETM-0-0-4440 [pii]
AID - 10.3892/etm.2017.4440 [doi]
PST - ppublish
SO  - Exp Ther Med. 2017 Jun;13(6):3586-3590. doi: 10.3892/etm.2017.4440. Epub 2017 May 
      8.