PMID- 28589140
OWN - NLM
STAT- MEDLINE
DCOM- 20180307
LR  - 20181113
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2017
DP  - 2017
TI  - Brain-Derived Neurotropic Factor Val66Met Polymorphism and Posttraumatic Stress 
      Disorder among Survivors of the 1998 Dongting Lake Flood in China.
PG  - 4569698
LID - 10.1155/2017/4569698 [doi]
LID - 4569698
AB  - OBJECTIVE: This study mainly aimed to explore the association between 
      brain-derived neurotropic factor (BDNF) Val66Met polymorphism and posttraumatic 
      stress disorder (PTSD) among flood survivors in China. METHODS: Individuals who 
      experienced the 1998 Dongting Lake flood in Southeast Huarong, China, were 
      enrolled in this study. Qualified health personnel carried out face-to-face 
      interviews with participants. PTSD was identified using PTSD Checklist-Civilian 
      version (PCL-C). Blood samples were collected from the participants to extract 
      DNA for genotyping. RESULTS: A total of 175 participants were enrolled in this 
      study. The prevalence of PTSD among flood survivors at 17-year follow-up was 
      16.0% (28/175). Individuals with PTSD were more likely to be female, experience 
      at least three flood-related stressors, experience at least three postflood 
      stressors, and carry the Met than those without PTSD. Compared with Val/Val 
      homozygotes, Met carriers had higher scores of PCL-C (mean +/- standard error: 
      23.60 +/- 7.23 versus 27.19 +/- 9.48, P < 0.05). Multivariable logistic regression 
      analysis indicated that Met carriers (aOR = 4.76, 95% CI = 1.02-22.15, P < 0.05) 
      were more likely to develop PTSD than Val/Val homozygotes. CONCLUSIONS: Met 
      carriers for BDNF rs6265 are at higher risk of developing PTSD and also exhibit 
      more severe PTSD symptoms than Val/Val homozygotes among flood survivors in 
      China.
FAU - Dai, Wenjie
AU  - Dai W
AD  - Department of Epidemiology and Health Statistics, Xiangya School of Public 
      Health, Central South University, Changsha, Hunan 410008, China.
FAU - Kaminga, Atipatsa C
AU  - Kaminga AC
AD  - Department of Epidemiology and Health Statistics, Xiangya School of Public 
      Health, Central South University, Changsha, Hunan 410008, China.
AD  - Department of Mathematics, Mzuzu University, Private Bag 201, Mzuzu 2, Malawi.
FAU - Wu, Xin
AU  - Wu X
AD  - Department of Epidemiology and Health Statistics, Xiangya School of Public 
      Health, Central South University, Changsha, Hunan 410008, China.
FAU - Wen, Shi Wu
AU  - Wen SW
AUID- ORCID: 0000-0002-7227-0283
AD  - Department of Epidemiology and Health Statistics, Xiangya School of Public 
      Health, Central South University, Changsha, Hunan 410008, China.
AD  - OMNI Research Group, Department of Obstetrics and Gynecology, Faculty of 
      Medicine, University of Ottawa, Ottawa, ON, Canada.
AD  - Ottawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa, ON, 
      Canada.
AD  - School of Epidemiology, Public Health, and Preventive Medicine, Faculty of 
      Medicine, University of Ottawa, Ottawa, ON, Canada.
FAU - Tan, Hongzhuan
AU  - Tan H
AD  - Department of Epidemiology and Health Statistics, Xiangya School of Public 
      Health, Central South University, Changsha, Hunan 410008, China.
FAU - Yan, Junxia
AU  - Yan J
AD  - Department of Epidemiology and Health Statistics, Xiangya School of Public 
      Health, Central South University, Changsha, Hunan 410008, China.
FAU - Deng, Jing
AU  - Deng J
AD  - Department of Epidemiology and Health Statistics, Xiangya School of Public 
      Health, Central South University, Changsha, Hunan 410008, China.
FAU - Lai, Zhiwei
AU  - Lai Z
AD  - Immune Planning Division, Hunan Provincial Center for Disease Control and 
      Prevention, Changsha, Hunan 410005, China.
FAU - Liu, Aizhong
AU  - Liu A
AUID- ORCID: 0000-0002-6794-4730
AD  - Department of Epidemiology and Health Statistics, Xiangya School of Public 
      Health, Central South University, Changsha, Hunan 410008, China.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20170514
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Amino Acid Substitution
MH  - Brain-Derived Neurotrophic Factor
MH  - China/epidemiology
MH  - Female
MH  - *Floods
MH  - Follow-Up Studies
MH  - Humans
MH  - *Lakes
MH  - Male
MH  - Middle Aged
MH  - *Mutation, Missense
MH  - *Polymorphism, Single Nucleotide
MH  - Prevalence
MH  - Stress Disorders, Post-Traumatic/epidemiology/*genetics
PMC - PMC5446855
EDAT- 2017/06/08 06:00
MHDA- 2018/03/08 06:00
PMCR- 2017/05/14
CRDT- 2017/06/08 06:00
PHST- 2017/01/24 00:00 [received]
PHST- 2017/04/20 00:00 [accepted]
PHST- 2017/06/08 06:00 [entrez]
PHST- 2017/06/08 06:00 [pubmed]
PHST- 2018/03/08 06:00 [medline]
PHST- 2017/05/14 00:00 [pmc-release]
AID - 10.1155/2017/4569698 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:4569698. doi: 10.1155/2017/4569698. Epub 2017 May 14.