PMID- 28589143
OWN - NLM
STAT- MEDLINE
DCOM- 20180307
LR  - 20181202
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2017
DP  - 2017
TI  - Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Relieve 
      Inflammatory Bowel Disease in Mice.
PG  - 5356760
LID - 10.1155/2017/5356760 [doi]
LID - 5356760
AB  - Exosomes secreted by mesenchymal stem cells (MSCs) have shown repairing effects 
      on several tissue injury diseases. In this study, we aimed to investigate the 
      effects of exosomes released from human umbilical cord mesenchymal stem cells 
      (hucMSCs) on the treatment of dextran sulfate sodium- (DSS-) induced inflammatory 
      bowel disease (IBD) and to explore the underlying mechanism. We found that 
      indocyanine green (ICG) labeled exosomes homed to colon tissues of IBD mice at 12 
      hours after injection. Exosomes significantly relieved the severity of IBD in 
      mice as hucMSCs. The expression of IL-10 gene was increased while that of TNF-alpha, 
      IL-1beta, IL-6, iNOS, and IL-7 genes was decreased in the colon tissues and spleens 
      of exosomes-treated mice. Furthermore, the infiltration of macrophages into the 
      colon tissues was decreased by exosome treatment in IBD mice. In addition, we 
      provided evidence that in vitro coculture with exosomes inhibited the expression 
      of iNOS and IL-7 in mouse enterocoelia macrophages. Moreover, we found that the 
      expression of IL-7 was higher in the colon tissues of colitis patients than that 
      of healthy controls. Our findings suggest that exosomes from hucMSCs have 
      profound effects on alleviating DSS-induced IBD and may exert their impact 
      through the modulation of IL-7 expression in macrophages.
FAU - Mao, Fei
AU  - Mao F
AUID- ORCID: 0000-0001-5840-4436
AD  - Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, 
      School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
FAU - Wu, Yunbing
AU  - Wu Y
AD  - Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, 
      School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
FAU - Tang, Xudong
AU  - Tang X
AD  - Jiangsu University of Science and Technology, Zhenjiang, Jiangsu 212018, China.
FAU - Kang, Jingjing
AU  - Kang J
AD  - Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, 
      School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
FAU - Zhang, Bin
AU  - Zhang B
AD  - Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, 
      School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
FAU - Yan, Yongmin
AU  - Yan Y
AD  - Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, 
      School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
FAU - Qian, Hui
AU  - Qian H
AUID- ORCID: 0000-0002-0098-3196
AD  - Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, 
      School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
FAU - Zhang, Xu
AU  - Zhang X
AUID- ORCID: 0000-0003-3492-4618
AD  - Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, 
      School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
FAU - Xu, Wenrong
AU  - Xu W
AUID- ORCID: 0000-0003-0903-1973
AD  - Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, 
      School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
LA  - eng
PT  - Journal Article
DEP - 20170515
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Cytokines)
RN  - 9042-14-2 (Dextran Sulfate)
SB  - IM
MH  - Animals
MH  - Colon/*metabolism/pathology
MH  - Cytokines/metabolism
MH  - Dextran Sulfate/toxicity
MH  - *Exosomes/metabolism/transplantation
MH  - Humans
MH  - Inflammatory Bowel Diseases/chemically induced/metabolism/pathology/*therapy
MH  - Macrophages/*metabolism/pathology
MH  - Mesenchymal Stem Cells/*metabolism/pathology
MH  - Mice
MH  - Umbilical Cord/*metabolism/pathology
PMC - PMC5447283
EDAT- 2017/06/08 06:00
MHDA- 2018/03/08 06:00
PMCR- 2017/05/15
CRDT- 2017/06/08 06:00
PHST- 2017/01/13 00:00 [received]
PHST- 2017/03/06 00:00 [revised]
PHST- 2017/03/14 00:00 [accepted]
PHST- 2017/06/08 06:00 [entrez]
PHST- 2017/06/08 06:00 [pubmed]
PHST- 2018/03/08 06:00 [medline]
PHST- 2017/05/15 00:00 [pmc-release]
AID - 10.1155/2017/5356760 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:5356760. doi: 10.1155/2017/5356760. Epub 2017 May 15.