PMID- 28589478 OWN - NLM STAT- MEDLINE DCOM- 20171213 LR - 20181202 IS - 1432-0711 (Electronic) IS - 0932-0067 (Linking) VI - 296 IP - 2 DP - 2017 Aug TI - Placental and cord blood brain derived neurotrophic factor levels are decreased in nondiabetic macrosomia. PG - 205-213 LID - 10.1007/s00404-017-4414-9 [doi] AB - PURPOSE: To measure levels of placental brain derived neurotrophic factor (BDNF) gene expression and umbilical cord blood BDNF in neonates with nondiabetic macrosomia and determine associations between these levels and macrosomia. METHODS: This case-control study included 58 nondiabetic macrosomic and 59 normal birth weight mother-infant pairs. Data were collected from interviews and our hospital's database. BDNF gene expression was quantified in placental tissues using quantitative real-time polymerase chain reaction (n = 117). Umbilical cord blood BDNF levels were measured by enzyme-linked immunosorbent assay (n = 90). Multivariate logistic regression models were used to evaluate associations between BDNF levels and macrosomia. RESULTS: Placental BDNF gene expression (P = 0.026) and cord blood BDNF (P = 0.008) were lower in neonates with nondiabetic macrosomia than in normal birth weight controls. Cord blood BDNF was significantly lower in vaginally delivered macrosomic neonates than vaginally delivered controls (P = 0.014), but cord BDNF did not differ between vaginal and cesarean section delivery modes in macrosomic neonates. Cord blood BDNF was positively associated with gestational age in control neonates (r = 0.496, P < 0.001), but not in macrosomic neonates. Cord blood BDNF was positively associated with placental BDNF relative expression (r (s) = 0.245, P = 0.02) in the total group. Higher cord blood BDNF levels were independently associated with protection against nondiabetic macrosomia (adjusted odds ratio 0.992; 95% confidence interval 0.986-0.998). CONCLUSIONS: Both placental BDNF gene expression and cord blood BDNF were downregulated in neonates with nondiabetic macrosomia compared with normal birth weight neonates. Cord BDNF may partly derive from BDNF secreted by the placenta. Higher cord plasma BDNF levels protected against nondiabetic macrosomia. FAU - Cai, Qian-Ying AU - Cai QY AD - Department of Preventive Medicine, School of Environmental Science and Public Health, Wenzhou Medical University, University Town, Wenzhou, 325035, Zhejiang, People's Republic of China. FAU - Zhang, Heng-Xin AU - Zhang HX AD - Department of Preventive Medicine, School of Environmental Science and Public Health, Wenzhou Medical University, University Town, Wenzhou, 325035, Zhejiang, People's Republic of China. FAU - Wang, Chen-Chen AU - Wang CC AD - Department of Preventive Medicine, School of Environmental Science and Public Health, Wenzhou Medical University, University Town, Wenzhou, 325035, Zhejiang, People's Republic of China. FAU - Sun, Hao AU - Sun H AD - Department of Preventive Medicine, School of Environmental Science and Public Health, Wenzhou Medical University, University Town, Wenzhou, 325035, Zhejiang, People's Republic of China. FAU - Sun, Shu-Qiang AU - Sun SQ AD - Department of Preventive Medicine, School of Environmental Science and Public Health, Wenzhou Medical University, University Town, Wenzhou, 325035, Zhejiang, People's Republic of China. FAU - Wang, Yu-Huan AU - Wang YH AD - Department of Obstetrics, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People's Republic of China. FAU - Yan, Hong-Tao AU - Yan HT AD - Department of Preventive Medicine, School of Environmental Science and Public Health, Wenzhou Medical University, University Town, Wenzhou, 325035, Zhejiang, People's Republic of China. FAU - Yang, Xin-Jun AU - Yang XJ AD - Department of Preventive Medicine, School of Environmental Science and Public Health, Wenzhou Medical University, University Town, Wenzhou, 325035, Zhejiang, People's Republic of China. xjyang@wzmc.edu.cn. LA - eng PT - Journal Article DEP - 20170606 PL - Germany TA - Arch Gynecol Obstet JT - Archives of gynecology and obstetrics JID - 8710213 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (RNA, Messenger) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adult MH - Animals MH - Birth Weight MH - Body Weight MH - Brain-Derived Neurotrophic Factor/genetics/*metabolism MH - Case-Control Studies MH - Enzyme-Linked Immunosorbent Assay MH - Female MH - Fetal Blood/*metabolism MH - Fetal Macrosomia/*blood/genetics MH - Gene Expression Regulation MH - Gestational Age MH - Humans MH - Infant, Newborn MH - Placenta/*metabolism MH - Pregnancy MH - RNA, Messenger MH - Real-Time Polymerase Chain Reaction OTO - NOTNLM OT - Brain derived neurotrophic factor OT - Case-control study OT - Macrosomia OT - Placenta OT - Umbilical cord blood EDAT- 2017/06/08 06:00 MHDA- 2017/12/14 06:00 CRDT- 2017/06/08 06:00 PHST- 2016/06/28 00:00 [received] PHST- 2017/05/30 00:00 [accepted] PHST- 2017/06/08 06:00 [pubmed] PHST- 2017/12/14 06:00 [medline] PHST- 2017/06/08 06:00 [entrez] AID - 10.1007/s00404-017-4414-9 [pii] AID - 10.1007/s00404-017-4414-9 [doi] PST - ppublish SO - Arch Gynecol Obstet. 2017 Aug;296(2):205-213. doi: 10.1007/s00404-017-4414-9. Epub 2017 Jun 6.