PMID- 28590303
OWN - NLM
STAT- MEDLINE
DCOM- 20180416
LR  - 20200317
IS  - 1473-5849 (Electronic)
IS  - 0955-8810 (Linking)
VI  - 28
IP  - 6
DP  - 2017 Sep
TI  - The immunomodulatory tellurium compound ammonium trichloro (dioxoethylene-O,O') 
      tellurate reduces anxiety-like behavior and corticosterone levels of submissive 
      mice.
PG  - 458-465
LID - 10.1097/FBP.0000000000000319 [doi]
AB  - Ammonium trichloro (dioxoethylene-O,O') tellurate (AS101) is a synthetic 
      organotellurium compound with potent immunomodulatory and neuroprotective 
      properties shown to inhibit the function of integrin alphavbeta3, a presynaptic 
      cell-surface-adhesion receptor. As partial deletion of alphavbeta3 downregulated 
      reuptake of serotonin by the serotonin transporter, we hypothesized that AS101 
      may influence pathways regulating anxiety. AS101 was tested in the modulation of 
      anxiety-like behavior using the selectively bred Submissive (Sub) mouse strain 
      that develop anxiety-like behavior in response to an i.p. injection. Mice were 
      treated daily with AS101 (i.p., 125 or 200 mug/kg) or vehicle for 3 weeks, after 
      which their anxiety-like behavior was measured in the elevated plus maze. Animals 
      were then culled for the measurement of serum corticosterone levels by ELISA and 
      hippocampal expression of brain-derived neurotrophic factor (BDNF) by RT-PCR. 
      Chronic administration of AS101 significantly reduced anxiety-like behavior of 
      Sub mice in the elevated plus maze, according to both time spent and entries to 
      open arms, relative to vehicle-treated controls. AS101 also markedly reduced 
      serum corticosterone levels of the treated mice and increased their hippocampal 
      BDNF expression. Anxiolytic-like effects of AS101 may be attributed to the 
      modulation of the regulatory influence integrin of alphavbeta3 upon the serotonin 
      transporter, suggesting a multifaceted mechanism by which AS101 buffers the 
      hypothalamic-pituitary-adrenal axis response to injection stress, enabling 
      recovery of hippocampal BDNF expression and anxiety-like behavior in Sub mice. 
      Further studies should advance the potential of AS101 in the context of 
      anxiety-related disorders.
FAU - Gross, Moshe
AU  - Gross M
AD  - aDepartment of Molecular Biology, Ariel University, Ariel bThe Safdie AIDS and 
      Immunology Research Center, C.A.I.R. Institute, The Mina and Everard Goodman 
      Faculty of Life Sciences cInterdisciplinary Department, Faculty of Social 
      Sciences, Bar-Ilan University, Ramat-Gan, Israel.
FAU - Stanciu, Emanuel
AU  - Stanciu E
FAU - Kenigsbuch-Sredni, Dvora
AU  - Kenigsbuch-Sredni D
FAU - Sredni, Benjamin
AU  - Sredni B
FAU - Pinhasov, Albert
AU  - Pinhasov A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Behav Pharmacol
JT  - Behavioural pharmacology
JID - 9013016
RN  - 0 (Ammonium Compounds)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Ethylenes)
RN  - 0 (Integrin alphaVbeta3)
RN  - 0 (Neuroprotective Agents)
RN  - 708681952A (ammonium trichloro(dioxoethylene-O,O'-)tellurate)
RN  - NQA0O090ZJ (Tellurium)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Ammonium Compounds
MH  - Animals
MH  - Anxiety/*drug therapy/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Corticosterone/analysis/blood
MH  - Disease Models, Animal
MH  - Ethylenes/metabolism/*pharmacology
MH  - Hypothalamo-Hypophyseal System/metabolism
MH  - Immunomodulation
MH  - Integrin alphaVbeta3/metabolism
MH  - Mice
MH  - Neuroprotective Agents
MH  - Pituitary-Adrenal System/metabolism
MH  - Tellurium
EDAT- 2017/06/08 06:00
MHDA- 2018/04/17 06:00
CRDT- 2017/06/08 06:00
PHST- 2017/06/08 06:00 [pubmed]
PHST- 2018/04/17 06:00 [medline]
PHST- 2017/06/08 06:00 [entrez]
AID - 10.1097/FBP.0000000000000319 [doi]
PST - ppublish
SO  - Behav Pharmacol. 2017 Sep;28(6):458-465. doi: 10.1097/FBP.0000000000000319.