PMID- 28591361
OWN - NLM
STAT- MEDLINE
DCOM- 20170822
LR  - 20220310
IS  - 1678-2674 (Electronic)
IS  - 0102-8650 (Linking)
VI  - 32
IP  - 5
DP  - 2017 May
TI  - Doppler velocimetry in fetal rats exposed to enoxaparin and unfractionated 
      heparin (UFH) during pregnancy.
PG  - 325-333
LID - S0102-86502017000500325 [pii]
LID - 10.1590/s0102-865020170050000001 [doi]
AB  - PURPOSE: To evaluate the effects of enoxaparin and unfractionated heparin (UFH) 
      administered in prophylactic and therapeutic doses on fetal vessels in healthy 
      pregnant Wistar rats, according to Doppler velocimetry measurements. METHODS: 
      Fifty animals were assigned to one of five groups: controls (saline), 
      prophylactic and therapeutic enoxaparin (1 and 2 mg/kg/day, respectively), and 
      prophylactic and therapeutic UFH (72 and 400 UI/kg/day, respectively). Uterine 
      horns were examined by ultrasound for identification of live fetuses. A sample of 
      these fetuses underwent Doppler velocimetry. Spectral curves, peak systolic 
      velocity (PSV), pulsatility index (PI), and resistance index (RI) of the middle 
      cerebral artery, ductus venosus, and umbilical artery were investigated. 
      Differences were considered statistically significant when p<0.05. RESULTS: No 
      significant differences in PSV, PI, or RI values were observed among the groups. 
      CONCLUSION: Doppler velocimetry measurements revealed no significant effects of 
      enoxaparin or unfractionated heparin on fetal vessels in pregnant Wistar rats.
FAU - Senefonte, Flavio Renato de Almeida
AU  - Senefonte FRA
AD  - Fellow PhD degree, Postgraduate Program in Health and Development, Universidade 
      Federal de Mato Grosso do Sul (UFMS), Campo Grande-MS, Brazil. Conception, 
      design, intellectual and scientific content of the study; technical procedures; 
      acquisition and interpretation of data; statistical analysis; manuscript writing; 
      critical revision.
FAU - Aydos, Ricardo Dutra
AU  - Aydos RD
AD  - PhD, Associate Professor, Department of Surgery, UFMS, Campo Grande-MS, Brazil. 
      Intellectual and scientific content of the study, critical revision, final 
      approval.
FAU - Oliveira, Vanessa Marcon de
AU  - Oliveira VM
AD  - PhD, Pharmacist, Centro de Ciencias Biologicas e da Saude, UFMS, Campo Grande-MS, 
      Brazil. Technical procedures, acquisition and interpretation of data.
FAU - Bosio, Marco Antonio Costa
AU  - Bosio MAC
AD  - MD, UFMS, Campo Grande-MS, Brazil. Technical procedures, acquisition and 
      interpretation of data.
FAU - Figueiro-Filho, Ernesto Antonio
AU  - Figueiro-Filho EA
AD  - PhD, Associate Professor, UFMS, Campo Grande-MS, Brazil. Conception, design, 
      intellectual and scientific content of the study; critical revision; final 
      approval.
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Acta Cir Bras
JT  - Acta cirurgica brasileira
JID - 9103983
RN  - 0 (Anticoagulants)
RN  - 0 (Enoxaparin)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Animals
MH  - Anticoagulants/*pharmacology
MH  - Blood Flow Velocity/*drug effects
MH  - Echocardiography, Doppler, Pulsed/methods
MH  - Enoxaparin/*pharmacology
MH  - Female
MH  - Fetus/*blood supply
MH  - Heparin/*pharmacology
MH  - Middle Cerebral Artery/*drug effects/physiopathology
MH  - Models, Animal
MH  - Pregnancy
MH  - Rats, Wistar
MH  - Ultrasonography, Prenatal/methods
MH  - Umbilical Arteries/*drug effects/physiopathology
MH  - Uterine Artery/*drug effects/physiopathology
MH  - Weight Gain/drug effects
EDAT- 2017/06/08 06:00
MHDA- 2017/08/23 06:00
CRDT- 2017/06/08 06:00
PHST- 2017/01/18 00:00 [received]
PHST- 2017/04/20 00:00 [accepted]
PHST- 2017/06/08 06:00 [entrez]
PHST- 2017/06/08 06:00 [pubmed]
PHST- 2017/08/23 06:00 [medline]
AID - S0102-86502017000500325 [pii]
AID - 10.1590/s0102-865020170050000001 [doi]
PST - ppublish
SO  - Acta Cir Bras. 2017 May;32(5):325-333. doi: 10.1590/s0102-865020170050000001.