PMID- 28591467
OWN - NLM
STAT- MEDLINE
DCOM- 20180723
LR  - 20220408
IS  - 1525-1594 (Electronic)
IS  - 0160-564X (Linking)
VI  - 41
IP  - 12
DP  - 2017 Dec
TI  - The Effect of Impella CP on Cardiopulmonary Physiology During Venoarterial 
      Extracorporeal Membrane Oxygenation Support.
PG  - 1109-1112
LID - 10.1111/aor.12923 [doi]
AB  - Left ventricle (LV) distension is a complication of venoarterial extracorporeal 
      membrane oxygenation (VA-ECMO) support. The effects of Impella on the pulmonary 
      circulatory physiology were studied in a single-center study of six consecutive 
      patients on VA-ECMO support who had LV unloading with Impella. Right ventricular 
      stroke volume, pulmonary hemodynamics, and partial pressure of end-tidal CO(2) 
      (PETCO(2) ) were measured on echocardiogram, pulmonary artery catheter, and 
      capnography, respectively. The addition of Impella CP increased total blood flow 
      and reduced pulmonary artery wedge pressure. There was a small reduction in 
      arterial oxygen saturation as Impella increased LV output. The increase in 
      pulmonary artery capacitance (PCap) exceeded the reduction in pulmonary vascular 
      resistance (PVR), thereby increasing the pulmonary artery time constant (product 
      of PCap and PVR). The right ventricular stroke volume increased and the 
      improvement in pulmonary hemodynamics and blood flow were associated with reduced 
      arterial-PETCO(2) gradient. The Impella CP unloads the LV during VA-ECMO support, 
      increasing total flow, reducing RV afterload, and facilitating RV output and 
      pulmonary blood flow with improvement in gas exchange.
CI  - (c) 2017 International Center for Artificial Organs and Transplantation and Wiley 
      Periodicals, Inc.
FAU - Lim, Hoong Sern
AU  - Lim HS
AD  - University Hospital Birmingham NHS Foundation Trust-Cardiology, Edgbaston, 
      Birmingham, United Kingdom.
LA  - eng
PT  - Journal Article
DEP - 20170607
PL  - United States
TA  - Artif Organs
JT  - Artificial organs
JID - 7802778
SB  - IM
MH  - Adult
MH  - *Extracorporeal Membrane Oxygenation/methods
MH  - Female
MH  - Heart Failure/physiopathology/therapy
MH  - *Heart-Assist Devices
MH  - *Hemodynamics
MH  - Humans
MH  - Lung/*blood supply/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Artery/physiopathology
MH  - Vascular Resistance
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - -Heart failure
OT  - -Ventricular assist device
OT  - Extracorporeal membrane oxygenation
EDAT- 2017/06/08 06:00
MHDA- 2018/07/24 06:00
CRDT- 2017/06/08 06:00
PHST- 2016/11/28 00:00 [received]
PHST- 2017/01/04 00:00 [revised]
PHST- 2017/01/10 00:00 [accepted]
PHST- 2017/06/08 06:00 [pubmed]
PHST- 2018/07/24 06:00 [medline]
PHST- 2017/06/08 06:00 [entrez]
AID - 10.1111/aor.12923 [doi]
PST - ppublish
SO  - Artif Organs. 2017 Dec;41(12):1109-1112. doi: 10.1111/aor.12923. Epub 2017 Jun 7.