PMID- 28592692
OWN - NLM
STAT- MEDLINE
DCOM- 20170818
LR  - 20200225
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 37
IP  - 28
DP  - 2017 Jul 12
TI  - Genome-Wide Temporal Expression Profiling in Caenorhabditis elegans Identifies a 
      Core Gene Set Related to Long-Term Memory.
PG  - 6661-6672
LID - 10.1523/JNEUROSCI.3298-16.2017 [doi]
AB  - The identification of genes related to encoding, storage, and retrieval of 
      memories is a major interest in neuroscience. In the current study, we analyzed 
      the temporal gene expression changes in a neuronal mRNA pool during an olfactory 
      long-term associative memory (LTAM) in Caenorhabditis elegans hermaphrodites. 
      Here, we identified a core set of 712 (538 upregulated and 174 downregulated) 
      genes that follows three distinct temporal peaks demonstrating multiple gene 
      regulation waves in LTAM. Compared with the previously published positive LTAM 
      gene set (Lakhina et al., 2015), 50% of the identified upregulated genes here 
      overlap with the previous dataset, possibly representing stimulus-independent 
      memory-related genes. On the other hand, the remaining genes were not previously 
      identified in positive associative memory and may specifically regulate aversive 
      LTAM. Our results suggest a multistep gene activation process during the 
      formation and retrieval of long-term memory and define general memory-implicated 
      genes as well as conditioning-type-dependent gene sets.SIGNIFICANCE STATEMENT The 
      identification of genes regulating different steps of memory is of major interest 
      in neuroscience. Identification of common memory genes across different learning 
      paradigms and the temporal activation of the genes are poorly studied. Here, we 
      investigated the temporal aspects of Caenorhabditis elegans gene expression 
      changes using aversive olfactory associative long-term memory (LTAM) and 
      identified three major gene activation waves. Like in previous studies, aversive 
      LTAM is also CREB dependent, and CREB activity is necessary immediately after 
      training. Finally, we define a list of memory paradigm-independent core gene sets 
      as well as conditioning-dependent genes.
CI  - Copyright (c) 2017 the authors 0270-6474/17/376661-12$15.00/0.
FAU - Freytag, Virginie
AU  - Freytag V
AD  - Transfaculty Research Platform Molecular and Cognitive Neurosciences.
AD  - Division of Molecular Neuroscience, Department of Psychology.
FAU - Probst, Sabine
AU  - Probst S
AD  - Division of Molecular Neuroscience, Department of Psychology.
AD  - Biozentrum, Life Sciences Training Facility, University of Basel, 4056 Basel, 
      Switzerland, and.
FAU - Hadziselimovic, Nils
AU  - Hadziselimovic N
AD  - Division of Molecular Neuroscience, Department of Psychology.
AD  - Biozentrum, Life Sciences Training Facility, University of Basel, 4056 Basel, 
      Switzerland, and.
FAU - Boglari, Csaba
AU  - Boglari C
AD  - Division of Molecular Neuroscience, Department of Psychology.
AD  - Biozentrum, Life Sciences Training Facility, University of Basel, 4056 Basel, 
      Switzerland, and.
FAU - Hauser, Yannick
AU  - Hauser Y
AD  - Transfaculty Research Platform Molecular and Cognitive Neurosciences.
AD  - Division of Molecular Neuroscience, Department of Psychology.
FAU - Peter, Fabian
AU  - Peter F
AD  - Transfaculty Research Platform Molecular and Cognitive Neurosciences.
AD  - Division of Molecular Neuroscience, Department of Psychology.
AD  - Biozentrum, Life Sciences Training Facility, University of Basel, 4056 Basel, 
      Switzerland, and.
FAU - Gabor Fenyves, Bank
AU  - Gabor Fenyves B
AD  - Division of Molecular Neuroscience, Department of Psychology.
AD  - Department of Medical Chemistry, Semmelweis University, 1094 Budapest, Hungary.
FAU - Milnik, Annette
AU  - Milnik A
AUID- ORCID: 0000-0002-3933-3289
AD  - Transfaculty Research Platform Molecular and Cognitive Neurosciences.
AD  - Division of Molecular Neuroscience, Department of Psychology.
AD  - University Psychiatric Clinics, and.
FAU - Demougin, Philippe
AU  - Demougin P
AD  - Biozentrum, Life Sciences Training Facility, University of Basel, 4056 Basel, 
      Switzerland, and.
FAU - Vukojevic, Vanja
AU  - Vukojevic V
AD  - Transfaculty Research Platform Molecular and Cognitive Neurosciences.
AD  - Division of Molecular Neuroscience, Department of Psychology.
AD  - Biozentrum, Life Sciences Training Facility, University of Basel, 4056 Basel, 
      Switzerland, and.
FAU - de Quervain, Dominique J-F
AU  - de Quervain DJ
AD  - Transfaculty Research Platform Molecular and Cognitive Neurosciences.
AD  - University Psychiatric Clinics, and.
AD  - Division of Cognitive Neuroscience, Department of Psychology, University of 
      Basel, 4055 Basel, Switzerland.
FAU - Papassotiropoulos, Andreas
AU  - Papassotiropoulos A
AD  - Transfaculty Research Platform Molecular and Cognitive Neurosciences.
AD  - Division of Molecular Neuroscience, Department of Psychology.
AD  - University Psychiatric Clinics, and.
AD  - Biozentrum, Life Sciences Training Facility, University of Basel, 4056 Basel, 
      Switzerland, and.
FAU - Stetak, Attila
AU  - Stetak A
AD  - Transfaculty Research Platform Molecular and Cognitive Neurosciences, 
      a.stetak@unibas.ch.
AD  - Division of Molecular Neuroscience, Department of Psychology.
AD  - University Psychiatric Clinics, and.
LA  - eng
GR  - P40 OD010440/OD/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20170607
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Proteome)
SB  - IM
MH  - Animals
MH  - Association Learning/physiology
MH  - Caenorhabditis elegans/*physiology
MH  - Caenorhabditis elegans Proteins/genetics/*metabolism
MH  - Chromosome Mapping
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation/*physiology
MH  - Genome/genetics
MH  - Memory, Long-Term/*physiology
MH  - Nerve Tissue Proteins/*genetics
MH  - Proteome/genetics/*metabolism
PMC - PMC6596549
OTO - NOTNLM
OT  - C. elegans
OT  - CREB
OT  - expression
OT  - genes
OT  - long-term memory
OT  - microarray
EDAT- 2017/06/09 06:00
MHDA- 2017/08/19 06:00
PMCR- 2018/01/12
CRDT- 2017/06/09 06:00
PHST- 2016/08/17 00:00 [received]
PHST- 2017/04/09 00:00 [revised]
PHST- 2017/05/10 00:00 [accepted]
PHST- 2017/06/09 06:00 [pubmed]
PHST- 2017/08/19 06:00 [medline]
PHST- 2017/06/09 06:00 [entrez]
PHST- 2018/01/12 00:00 [pmc-release]
AID - JNEUROSCI.3298-16.2017 [pii]
AID - 3298-16 [pii]
AID - 10.1523/JNEUROSCI.3298-16.2017 [doi]
PST - ppublish
SO  - J Neurosci. 2017 Jul 12;37(28):6661-6672. doi: 10.1523/JNEUROSCI.3298-16.2017. 
      Epub 2017 Jun 7.