PMID- 28593345
OWN - NLM
STAT- MEDLINE
DCOM- 20180718
LR  - 20180718
IS  - 1661-4917 (Electronic)
IS  - 0004-069X (Linking)
VI  - 65
IP  - 6
DP  - 2017 Dec
TI  - Exocrine Gland Morphogenesis: Insights into the Role of Amphiregulin from 
      Development to Disease.
PG  - 477-499
LID - 10.1007/s00005-017-0478-2 [doi]
AB  - Amphiregulin (AREG) is a well-characterized member of the epidermal growth factor 
      (EGF) family and is one of the ligands of the EGF receptor (EGFR). AREG plays a 
      key role in mammalian development and in the control of branching morphogenesis 
      in various organs. Furthermore, AREG participates in a wide range of 
      physiological and pathological processes activating the major intracellular 
      signalling cascades governing cell survival, proliferation and motility. In this 
      article, we review current advances in exocrine glands morphogenesis, focusing on 
      the salivary gland, and discuss the essential aspects of AREG structure, function 
      and regulation, and its differential role within the EGFR family of ligands. 
      Finally, we identify emerging aspects in AREG research applied to mammary gland 
      development and the salivary gland autoimmune disease, Sjogren's syndrome.
FAU - Sisto, Margherita
AU  - Sisto M
AD  - Section of Human Anatomy and Histology, Laboratory of Cell Biology, Department of 
      Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "Aldo 
      Moro", Piazza Giulio Cesare 1, 70124, Bari, Italy. margherita.sisto@uniba.it.
FAU - Lorusso, Loredana
AU  - Lorusso L
AD  - Section of Human Anatomy and Histology, Laboratory of Cell Biology, Department of 
      Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "Aldo 
      Moro", Piazza Giulio Cesare 1, 70124, Bari, Italy.
FAU - Ingravallo, Giuseppe
AU  - Ingravallo G
AD  - Pathology Section, Department of Emergency and Organ Transplantation (DETO), 
      University of Bari "Aldo Moro", Bari, Italy.
FAU - Lisi, Sabrina
AU  - Lisi S
AD  - Section of Human Anatomy and Histology, Laboratory of Cell Biology, Department of 
      Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "Aldo 
      Moro", Piazza Giulio Cesare 1, 70124, Bari, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170607
PL  - Poland
TA  - Arch Immunol Ther Exp (Warsz)
JT  - Archivum immunologiae et therapiae experimentalis
JID - 0114365
RN  - 0 (Amphiregulin)
RN  - 62229-50-9 (Epidermal Growth Factor)
SB  - IM
MH  - Amphiregulin/genetics/*metabolism
MH  - Animals
MH  - Epidermal Growth Factor/metabolism
MH  - Epithelial Cells/*physiology
MH  - Exocrine Glands/*physiology
MH  - Fibroblasts/*physiology
MH  - Gene Expression Regulation, Developmental
MH  - Humans
MH  - Morphogenesis
MH  - Salivary Glands/*physiology
MH  - Signal Transduction
MH  - Sjogren's Syndrome/*genetics/metabolism
OTO - NOTNLM
OT  - Amphiregulin
OT  - Epidermal growth factor
OT  - Exocrine glands
OT  - Morphogenesis
OT  - Salivary gland
OT  - Sjogren's syndrome
EDAT- 2017/06/09 06:00
MHDA- 2018/07/19 06:00
CRDT- 2017/06/09 06:00
PHST- 2016/11/17 00:00 [received]
PHST- 2017/06/02 00:00 [accepted]
PHST- 2017/06/09 06:00 [pubmed]
PHST- 2018/07/19 06:00 [medline]
PHST- 2017/06/09 06:00 [entrez]
AID - 10.1007/s00005-017-0478-2 [pii]
AID - 10.1007/s00005-017-0478-2 [doi]
PST - ppublish
SO  - Arch Immunol Ther Exp (Warsz). 2017 Dec;65(6):477-499. doi: 
      10.1007/s00005-017-0478-2. Epub 2017 Jun 7.