PMID- 28593372
OWN - NLM
STAT- MEDLINE
DCOM- 20180409
LR  - 20180409
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Linking)
VI  - 409
IP  - 19
DP  - 2017 Jul
TI  - Simultaneous determination of dechloranes, polybrominated diphenyl ethers and 
      novel brominated flame retardants in food and serum.
PG  - 4507-4515
LID - 10.1007/s00216-017-0411-x [doi]
AB  - A sensitive method for the simultaneous quantification of dechloranes, 
      polybrominated diphenyl ethers (PBDEs) and novel brominated flame retardants 
      (NBFRs) has been developed for gas chromatography (GC) coupled to tandem mass 
      spectrometry operating in electron capture negative ionization (ECNI) mode. The 
      major advance has been achieved by combining selected ion monitoring (SIM) and 
      multiple reaction monitoring (MRM) modes in well-defined time windows, to 
      determine dechloranes, PBDEs and NBFRs at picogram per gram level in one single 
      analysis in complex matrix biological samples. From the chromatographic point of 
      view, efforts were devoted to study several injection modes using multimode inlet 
      (MMI) in order to obtain low instrumental detection limits, necessary for trace 
      compounds such as Dechlorane Plus (DP) isomers. Method performance was also 
      evaluated: calibration curves were linear from 20 fg muL(-1) to 100 pg muL(-1) for 
      the studied compounds, with method detection limits at levels of 50 fg g(-1) for 
      DPs. Repeatability and reproducibility, expressed as relative standard deviation, 
      were better than 5% even in solvent vent mode for the injection of standards. The 
      application to a wide range of complex samples (including food, human and animal 
      serum samples) indicated a sensitive and reliable way to quantify at the picogram 
      per gram level 4 halogenated norbornenes (HNs), Dechlorane Plus (anti-DP and 
      syn-DP) and 2 of their homologues (Dechlorane-602 and Dechlorane-603), 11 PBDE 
      congeners (no. 28, 47, 49, 66, 85, 99, 100, 153, 154, 183 and 209) and 5 novel 
      BFRs, i.e. decabromodiphenyl ethane (DBDPE), 1,2-bis(2,4,6-tribromophenoxy)ethane 
      (BTBPE), hexabromobenzene (HBB), 2,3,4,5-tetrabromo-ethylhexyl-benzoate (TBB) and 
      tetrabromophthalate (TBPH). Graphical Abstract GC-ECNI-MS/MS chromatograms 
      showing the most sensitive transition for DPs when injecting 2 muL of a 16 fg/muL 
      standard solution of s-DP and a-DP at three different source temperatures.
FAU - Sales, Carlos
AU  - Sales C
AUID- ORCID: 0000-0001-6337-063X
AD  - Research Institute for Pesticides and Water, University Jaume I, Av. de Vicent 
      Sos Baynat, s/n, 12071, Castellon, Spain. casales@uji.es.
FAU - Poma, Giulia
AU  - Poma G
AD  - Toxicological Centre, Department of Pharmaceutical Sciences, University of 
      Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium.
FAU - Malarvannan, Govindan
AU  - Malarvannan G
AD  - Toxicological Centre, Department of Pharmaceutical Sciences, University of 
      Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium.
FAU - Portoles, Tania
AU  - Portoles T
AD  - Research Institute for Pesticides and Water, University Jaume I, Av. de Vicent 
      Sos Baynat, s/n, 12071, Castellon, Spain.
FAU - Beltran, Joaquin
AU  - Beltran J
AD  - Research Institute for Pesticides and Water, University Jaume I, Av. de Vicent 
      Sos Baynat, s/n, 12071, Castellon, Spain.
FAU - Covaci, Adrian
AU  - Covaci A
AD  - Toxicological Centre, Department of Pharmaceutical Sciences, University of 
      Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium. 
      adrian.covaci@uantwerpen.be.
LA  - eng
PT  - Journal Article
DEP - 20170608
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 0 (Flame Retardants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
SB  - IM
MH  - Animals
MH  - Flame Retardants/*analysis
MH  - *Food Analysis
MH  - Halogenated Diphenyl Ethers/*analysis/blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*analysis/blood
OTO - NOTNLM
OT  - Biological matrices
OT  - Brominated flame retardants
OT  - Chemical ionization
OT  - Dechloranes
OT  - Gas chromatography
OT  - Large volume injection
EDAT- 2017/06/09 06:00
MHDA- 2018/04/10 06:00
CRDT- 2017/06/09 06:00
PHST- 2017/02/08 00:00 [received]
PHST- 2017/05/12 00:00 [accepted]
PHST- 2017/04/14 00:00 [revised]
PHST- 2017/06/09 06:00 [pubmed]
PHST- 2018/04/10 06:00 [medline]
PHST- 2017/06/09 06:00 [entrez]
AID - 10.1007/s00216-017-0411-x [pii]
AID - 10.1007/s00216-017-0411-x [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2017 Jul;409(19):4507-4515. doi: 10.1007/s00216-017-0411-x. 
      Epub 2017 Jun 8.