PMID- 28593819
OWN - NLM
STAT- MEDLINE
DCOM- 20200102
LR  - 20211204
IS  - 1814-1412 (Electronic)
IS  - 1562-2975 (Linking)
VI  - 20
IP  - 3
DP  - 2019 Mar
TI  - Voluntary exercise improves cognitive deficits in female dominant-negative DISC1 
      transgenic mouse model of neuropsychiatric disorders.
PG  - 243-252
LID - 10.1080/15622975.2017.1323118 [doi]
AB  - OBJECTIVES: Physical exercise has gained increasing interest as a treatment 
      modality that improves prognosis in psychiatric patients. The disrupted in 
      schizophrenia 1 (DISC1) gene is a candidate gene for major mental illness. In 
      this study, we aimed to determine whether voluntary wheel running can improve 
      cognitive deficits of dominant-negative DISC1 transgenic mice (DN-DISC1). 
      METHODS: DN-DISC1 and control mice (10-week-old male and female) were placed for 
      14 days in a cage with or without access to a running wheel. Two weeks later, 
      mice underwent behavioural tests evaluating cognition and social approach and 
      recognition. RESULTS: Voluntary exercise improved performance in the novel object 
      recognition test, restored the impairment in spatial memory in the Y maze, and 
      reversed the deficit in social recognition memory in DN-DISC1 females. DN-DISC1 
      males did not exhibit behavioural deficits at baseline. Tissue analysis revealed 
      that exercise induced a significant increase in hippocampal expression of 
      doublecortin (DCX), brain-derived neurotrophic factor (BDNF) and cannabinoid 
      receptor type 1 (CB1R) only in DN-DISC1 females. CONCLUSIONS: Voluntary exercise 
      is beneficial in attenuating cognitive deficits observed in a rodent model 
      relevant for neuropsychiatric disorders. The data add a preclinical aspect to the 
      accumulating clinical data supporting the incorporation of physical exercise to 
      patients' care.
FAU - Segal-Gavish, Hadar
AU  - Segal-Gavish H
AD  - a Laboratory of Neuroscience , Felsenstein Medical Research Center, Sackler 
      Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
FAU - Barzilay, Ran
AU  - Barzilay R
AD  - a Laboratory of Neuroscience , Felsenstein Medical Research Center, Sackler 
      Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
AD  - b Research Unit , Geha Mental Health Center , Petach Tikva , Israel.
FAU - Rimoni, Ofri
AU  - Rimoni O
AD  - a Laboratory of Neuroscience , Felsenstein Medical Research Center, Sackler 
      Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
FAU - Offen, Daniel
AU  - Offen D
AD  - a Laboratory of Neuroscience , Felsenstein Medical Research Center, Sackler 
      Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170608
PL  - England
TA  - World J Biol Psychiatry
JT  - The world journal of biological psychiatry : the official journal of the World 
      Federation of Societies of Biological Psychiatry
JID - 101120023
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (DCX protein, human)
RN  - 0 (Dcx protein, mouse)
RN  - 0 (Disc1 protein, mouse)
RN  - 0 (Doublecortin Domain Proteins)
RN  - 0 (Doublecortin Protein)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (Receptor, Cannabinoid, CB1)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cognitive Dysfunction/metabolism/*therapy
MH  - Disease Models, Animal
MH  - Doublecortin Domain Proteins
MH  - Doublecortin Protein
MH  - Female
MH  - Hippocampus/metabolism/*physiopathology
MH  - Humans
MH  - Male
MH  - *Maze Learning
MH  - Mice
MH  - Mice, Transgenic
MH  - Microtubule-Associated Proteins/metabolism
MH  - Nerve Tissue Proteins/genetics
MH  - Neuropeptides/metabolism
MH  - *Physical Conditioning, Animal
MH  - Receptor, Cannabinoid, CB1/metabolism
MH  - Running
MH  - Schizophrenia/metabolism/*therapy
OTO - NOTNLM
OT  - DISC1
OT  - animal model
OT  - exercise
OT  - neurogenesis
OT  - recognition memory
EDAT- 2017/06/09 06:00
MHDA- 2020/01/03 06:00
CRDT- 2017/06/09 06:00
PHST- 2017/06/09 06:00 [pubmed]
PHST- 2020/01/03 06:00 [medline]
PHST- 2017/06/09 06:00 [entrez]
AID - 10.1080/15622975.2017.1323118 [doi]
PST - ppublish
SO  - World J Biol Psychiatry. 2019 Mar;20(3):243-252. doi: 
      10.1080/15622975.2017.1323118. Epub 2017 Jun 8.