PMID- 28593896
OWN - NLM
STAT- MEDLINE
DCOM- 20190701
LR  - 20191007
IS  - 1857-9345 (Print)
IS  - 1857-9345 (Linking)
VI  - 38
IP  - 1
DP  - 2017 Mar 1
TI  - Synergistic Effect of Hyperoxia and Biotrauma On Ventilator-Induced Lung Injury.
PG  - 91-96
LID - /j/prilozi.2017.38.issue-1/prilozi-2017-0012/prilozi-2017-0012.xml [pii]
LID - 10.1515/prilozi-2017-0012 [doi]
AB  - Patients undergoing mechanical ventilation in intensive care units (ICUs) may 
      develop ventilator-induced lung injury (VILI). Beside the high tidal volume (Vt) 
      and plateau pressure (Pplat), hyperoxia is supposed to precipitate lung injury. 
      Oxygen toxicity is presumed to occur at levels of fraction of inspired oxygen 
      (FiO2) exceeding 0.40. The exposure time to hyperoxia is certainly very important 
      and patients who spend extended time on mechanical ventilation (MV) are probably 
      more exposed to severe hyperoxic acute lung injury (HALI). Together, hyperoxia 
      and biotrauma (release of cytokines) have a synergistic effect and can induce 
      VILI. In the clinical practice, the reduction of FiO2 to safe levels through the 
      appropriate use of the positive end expiratory pressure (PEEP) and the alignment 
      of mean airway pressure is an appropriate goal. The strategy for lung protective 
      ventilation must include setting up FiO2 to a safe level that is accomplished by 
      using PaO2/FiO2 ratio with a lower limit of FiO2 to achieve acceptable levels of 
      PaO2, which will be safe for the patient without local (lungs) or systemic 
      inflammatory response. The protocol from the ARDS-net study is used for 
      ventilator setup and adjustment. Cytokines (IL-1, IL-6, TNFalpha and MIP-2) that are 
      involved in the inflammatory response are determined in order to help the 
      therapeutic approach in counteracting HALI. Computed tomography findings reflect 
      the pathological phases of the diffuse alveolar damage. At least preferably the 
      lowest level of FiO2 should be used in order to provide full lung protection 
      against the damage induced by MV.
FAU - Shosholcheva, Mirjana
AU  - Shosholcheva M
AD  - University Clinic of Surgery "Ss. Naum Ohridski", Medical Faculty, "Ss. Cyril and 
      Methodius" University.
FAU - capital JE, Serbianankulovski, Nikola
AU  - capital JE, Serbianankulovski N
AD  - University Clinic for Abdominal Surgery, Medical Faculty, "Ss. Cyril and 
      Methodius" University.
FAU - Kartalov, Andrijan
AU  - Kartalov A
AD  - Clinic for Anesthesiology, Reanimatology and Intensive Care Unit, Medical 
      Faculty, "Ss. Cyril and Methodius" University.
FAU - Kuzmanovska, Biljana
AU  - Kuzmanovska B
AD  - Clinic for Anesthesiology, Reanimatology and Intensive Care Unit, Medical 
      Faculty, "Ss. Cyril and Methodius" University.
FAU - Miladinova, Daniela
AU  - Miladinova D
AD  - Institute of Pathophysiology and Nuclear Medicine, Medical Faculty, "Ss. Cyril 
      and Methodius" University.
LA  - eng
PT  - Journal Article
PL  - North Macedonia
TA  - Pril (Makedon Akad Nauk Umet Odd Med Nauki)
JT  - Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski 
      nauki)
JID - 101677081
RN  - 0 (Chemokine CXCL2)
RN  - 0 (IL6 protein, human)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Acute Lung Injury/*etiology/metabolism/physiopathology/prevention & control
MH  - Animals
MH  - Chemokine CXCL2/metabolism
MH  - Humans
MH  - Hyperoxia/*complications/metabolism/physiopathology/prevention & control
MH  - Inflammation Mediators/metabolism
MH  - Interleukin-1/metabolism
MH  - Interleukin-6/metabolism
MH  - *Lung/metabolism/physiopathology
MH  - Protective Factors
MH  - Respiration, Artificial/*adverse effects
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Ventilator-Induced Lung Injury/*etiology/metabolism/physiopathology/prevention & 
      control
OTO - NOTNLM
OT  - cytokines
OT  - hyperoxia
OT  - lung-protective ventilation strategies
OT  - ventilator-induced lung injury
EDAT- 2017/06/09 06:00
MHDA- 2019/07/02 06:00
CRDT- 2017/06/09 06:00
PHST- 2017/06/09 06:00 [entrez]
PHST- 2017/06/09 06:00 [pubmed]
PHST- 2019/07/02 06:00 [medline]
AID - /j/prilozi.2017.38.issue-1/prilozi-2017-0012/prilozi-2017-0012.xml [pii]
AID - 10.1515/prilozi-2017-0012 [doi]
PST - ppublish
SO  - Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2017 Mar 1;38(1):91-96. doi: 
      10.1515/prilozi-2017-0012.