PMID- 28594085
OWN - NLM
STAT- MEDLINE
DCOM- 20180402
LR  - 20231112
IS  - 1526-9914 (Electronic)
IS  - 1526-9914 (Linking)
VI  - 18
IP  - 4
DP  - 2017 Jul
TI  - Preliminary study of clinical application on IMRT three-dimensional dose 
      verification-based EPID system.
PG  - 97-105
LID - 10.1002/acm2.12098 [doi]
AB  - The three-dimensional dose (3D) distribution of intensity-modulated radiation 
      therapy (IMRT) was verified based on electronic portal imaging devices (EPIDs), 
      and the results were analyzed. Thirty IMRT plans of different lesions were 
      selected for 3D EPID-based dose verification. The gamma passing rates of the 3D 
      dose verification-based EPID system (Edose, Version 3.01, Raydose, Guangdong, 
      China) and Delta4 measurements were then compared with treatment planning system 
      (TPS) calculations using global gamma criteria of 5%/3 mm, 3%/3 mm, and 2%/2 mm. 
      Furthermore, the dose-volume histograms (DVHs) for planning target volumes (PTVs) 
      as well as organs at risk (OARs) were analyzed using Edose. For dose verification 
      of the 30 treatment plans, the average gamma passing rates of Edose 
      reconstructions under the gamma criteria of 5%/3 mm, 3%/3 mm, and 2%/2 mm were 
      (98.58 +/- 0.93)%, (95.67 +/- 1.97)%, and (83.13 +/- 4.53)%, respectively, whereas the 
      Delta4 measurement results were (99.14% +/- 1.16)%, (95.81% +/- 2.88)%, and (84.74% +/- 
      7.00)%, respectively. The dose differences between Edose reconstructions and TPS 
      calculations were within 3% for D(95%) , D(98%) , and D(mean) in each PTV, with 
      the exception that the D(98%) of the PTV-clinical target volume (CTV) in 
      esophageal carcinoma cases was (3.21 +/- 2.33)%. However, the larger dose 
      deviations in OARs (such as lens, parotid gland, optic nerve, and spinal cord) 
      can be determined based on DVHs. The difference was particularly obvious for OARs 
      with small volumes; for example, the maximum dose deviation for the lens reached 
      (-6.12 +/- 5.28)%. A comparison of the results obtained with Edose and Delta4 
      indicated that the Edose system could be applied for 3D pretreatment dose 
      verification of IMRT. This system could also be utilized to evaluate the gamma 
      passing rate of each treatment plan. Furthermore, the detailed dose distributions 
      of PTVs and OARs could be indicated based on DVHs, providing additional reliable 
      data for quality assurance in a clinic setting.
CI  - (c) 2017 The Authors. Journal of Applied Clinical Medical Physics published by 
      Wiley Periodicals, Inc. on behalf of American Association of Physicists in 
      Medicine.
FAU - Huang, Miaoyun
AU  - Huang M
AD  - Department of Radiation Oncology, Fujian Medical University Union Hospital, 
      Fuzhou, China.
FAU - Huang, David
AU  - Huang D
AD  - Medical Physics Graduate Program, Duke Kunshan University, Kunshan, China.
FAU - Zhang, Jianping
AU  - Zhang J
AD  - Department of Radiation Oncology, Fujian Medical University Union Hospital, 
      Fuzhou, China.
FAU - Chen, Yuangui
AU  - Chen Y
AD  - Department of Radiation Oncology, Fujian Medical University Union Hospital, 
      Fuzhou, China.
FAU - Xu, Benhua
AU  - Xu B
AD  - Department of Radiation Oncology, Fujian Medical University Union Hospital, 
      Fuzhou, China.
FAU - Chen, Lixin
AU  - Chen L
AD  - State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer 
      Center, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20170608
PL  - United States
TA  - J Appl Clin Med Phys
JT  - Journal of applied clinical medical physics
JID - 101089176
SB  - IM
MH  - Esophageal Neoplasms/*radiotherapy
MH  - Gamma Rays
MH  - Humans
MH  - Lens, Crystalline/radiation effects
MH  - Optic Nerve/radiation effects
MH  - Organs at Risk/*radiation effects
MH  - Parotid Gland/radiation effects
MH  - Radiotherapy Dosage
MH  - *Radiotherapy Planning, Computer-Assisted
MH  - Radiotherapy, Intensity-Modulated/*methods
MH  - Spinal Cord/radiation effects
PMC - PMC5875845
OTO - NOTNLM
OT  - Delta4
OT  - electronic portal imaging system (EPID)
OT  - intensity-modulated radiation therapy
OT  - quality assurance
OT  - three-dimensional dose verification
EDAT- 2017/06/09 06:00
MHDA- 2018/04/03 06:00
PMCR- 2017/06/08
CRDT- 2017/06/09 06:00
PHST- 2017/01/04 00:00 [received]
PHST- 2017/02/16 00:00 [revised]
PHST- 2017/04/02 00:00 [accepted]
PHST- 2017/06/09 06:00 [pubmed]
PHST- 2018/04/03 06:00 [medline]
PHST- 2017/06/09 06:00 [entrez]
PHST- 2017/06/08 00:00 [pmc-release]
AID - ACM212098 [pii]
AID - 10.1002/acm2.12098 [doi]
PST - ppublish
SO  - J Appl Clin Med Phys. 2017 Jul;18(4):97-105. doi: 10.1002/acm2.12098. Epub 2017 
      Jun 8.