PMID- 28594137
OWN - NLM
STAT- MEDLINE
DCOM- 20180206
LR  - 20220311
IS  - 1930-739X (Electronic)
IS  - 1930-7381 (Linking)
VI  - 25
IP  - 8
DP  - 2017 Aug
TI  - Increased Adipocyte Size, Macrophage Infiltration, and Adverse Local Adipokine 
      Profile in Perirenal Fat in Cushing's Syndrome.
PG  - 1369-1374
LID - 10.1002/oby.21887 [doi]
AB  - OBJECTIVE: To analyze changes in fat cell size, macrophage infiltration, and 
      local adipose tissue adipokine profiles in different fat depots in patients with 
      active Cushing's syndrome. METHODS: Subcutaneous (SC) and perirenal (PR) adipose 
      tissue of 10 patients with Cushing's syndrome was compared to adipose tissue of 
      10 gender-, age-, and BMI-matched controls with regard to adipocyte size 
      determined by digital image analysis on hematoxylin and eosin stainings, 
      macrophage infiltration determined by digital image analysis on CD68 stainings, 
      and adipose tissue leptin and adiponectin levels using fluorescent bead 
      immunoassays and ELISA techniques. RESULTS: Compared to the controls, mean 
      adipocyte size was larger in PR adipose tissue in patients. The percentage of 
      macrophage infiltration of the PR adipose tissue and PR adipose tissue lysate 
      leptin levels were higher and adiponectin levels were lower in SC and PR adipose 
      tissue lysates in patients. The adiponectin levels were also lower in the SC 
      adipose tissue supernatants of patients. Associations were found between the 
      severity of hypercortisolism and PR adipocyte size. CONCLUSIONS: Cushing's 
      syndrome is associated with hypertrophy of PR adipocytes and a higher percentage 
      of macrophage infiltration in PR adipose tissue. These changes are associated 
      with an adverse local adipokine profile.
CI  - (c) 2017 The Obesity Society.
FAU - Roerink, Sean H P P
AU  - Roerink SHPP
AD  - Department of Medicine, Division of Endocrinology, Radboud University Medical 
      Center, Nijmegen, the Netherlands.
FAU - Wagenmakers, Margreet A E M
AU  - Wagenmakers MAEM
AD  - Department of Medicine, Division of Endocrinology, Radboud University Medical 
      Center, Nijmegen, the Netherlands.
FAU - Langenhuijsen, Johan F
AU  - Langenhuijsen JF
AD  - Department of Urology, Radboud University Medical Center, Nijmegen, the 
      Netherlands.
FAU - Ballak, Dov B
AU  - Ballak DB
AD  - Department of Medicine, Division of Endocrinology, Radboud University Medical 
      Center, Nijmegen, the Netherlands.
FAU - Rooijackers, Hanne M M
AU  - Rooijackers HMM
AD  - Department of Medicine, Division of Endocrinology, Radboud University Medical 
      Center, Nijmegen, the Netherlands.
FAU - d'Ancona, Frank C
AU  - d'Ancona FC
AD  - Department of Urology, Radboud University Medical Center, Nijmegen, the 
      Netherlands.
FAU - van Dielen, Francois M
AU  - van Dielen FM
AD  - Department of General Surgery, Maxima Medical Center Eindhoven, Eindhoven, the 
      Netherlands.
FAU - Smit, Jan W A
AU  - Smit JWA
AD  - Department of Medicine, Division of Endocrinology, Radboud University Medical 
      Center, Nijmegen, the Netherlands.
FAU - Plantinga, Theo S
AU  - Plantinga TS
AD  - Department of Medicine, Division of Endocrinology, Radboud University Medical 
      Center, Nijmegen, the Netherlands.
FAU - Netea-Maier, Romana T
AU  - Netea-Maier RT
AD  - Department of Medicine, Division of Endocrinology, Radboud University Medical 
      Center, Nijmegen, the Netherlands.
FAU - Hermus, Ad R M M
AU  - Hermus ARMM
AD  - Department of Medicine, Division of Endocrinology, Radboud University Medical 
      Center, Nijmegen, the Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20170608
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
RN  - 0 (Adipokines)
RN  - 0 (Leptin)
SB  - IM
MH  - Adipocytes/*cytology
MH  - Adipokines/*blood
MH  - Adult
MH  - Aged
MH  - Body Mass Index
MH  - *Cell Size
MH  - Cross-Sectional Studies
MH  - Cushing Syndrome/*blood/complications
MH  - Female
MH  - Humans
MH  - Hypertrophy/blood/complications
MH  - Intra-Abdominal Fat/*metabolism
MH  - Leptin/metabolism
MH  - Macrophages/*cytology
MH  - Male
MH  - Middle Aged
MH  - Young Adult
EDAT- 2017/06/09 06:00
MHDA- 2018/02/07 06:00
CRDT- 2017/06/09 06:00
PHST- 2017/03/23 00:00 [received]
PHST- 2017/04/19 00:00 [revised]
PHST- 2017/04/27 00:00 [accepted]
PHST- 2017/06/09 06:00 [pubmed]
PHST- 2018/02/07 06:00 [medline]
PHST- 2017/06/09 06:00 [entrez]
AID - 10.1002/oby.21887 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2017 Aug;25(8):1369-1374. doi: 10.1002/oby.21887. Epub 
      2017 Jun 8.