PMID- 28595187 OWN - NLM STAT- MEDLINE DCOM- 20180423 LR - 20221207 IS - 1421-9697 (Electronic) IS - 0250-6807 (Linking) VI - 70 IP - 4 DP - 2017 TI - rs10767664 Gene Variant in Brain-Derived Neurotrophic Factor Is Associated with Diabetes Mellitus Type 2 in Caucasian Females with Obesity. PG - 286-292 LID - 10.1159/000474956 [doi] AB - BACKGROUND: The role of brain-derived neurotrophic factor (BDNF) variants on diabetes prevalence, basal adipokine levels, body weight, and cardiovascular risk factors remains unclear in obese patients. OBJECTIVE: This study is aimed at analyzing the effects of rs10767664 BDNF gene polymorphism on diabetes mellitus prevalence, body weight, cardiovascular risk factors, and serum adipokine levels in obese female patients. DESIGN: A total of 507 obese women were enrolled in a prospective way. Biochemical evaluation and anthropometric measures were recorded. RESULTS: The frequency of diabetes mellitus in the group of patients with non-T allele was 20.1 and 28.3% in T-allele carriers. Logistic regression showed a risk of diabetes mellitus of 1.33 (95% CI 1.17-2.08) in subjects with T allele adjusted by age and body mass index (BMI). T-allele carriers with diabetes mellitus have a higher weight, BMI, waist circumference, blood pressure, glucose, homeostasis model assessment insulin resistance (HOMA-IR), insulin, and C-reactive protein (CRP) levels than non-T-allele carriers. CONCLUSION: rs10767664 polymorphism of BDNF gene is associated with prevalence of diabetes mellitus in obese female patients. T-allele carriers with diabetes mellitus have a higher weight, fat mass, blood pressure, level of insulin, glucose, HOMA-IR, and CRP than non-T-allele carriers. CI - (c) 2017 S. Karger AG, Basel. FAU - de Luis, Daniel Antonio AU - de Luis DA AD - Center of Investigation of Endocrinology and Nutrition, Medicine School and Department of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain. FAU - Aller, Rocio AU - Aller R FAU - Izaola, Olatz AU - Izaola O FAU - Primo, David AU - Primo D FAU - Romero, Enrique AU - Romero E LA - eng PT - Journal Article DEP - 20170609 PL - Switzerland TA - Ann Nutr Metab JT - Annals of nutrition & metabolism JID - 8105511 RN - 0 (Adipokines) RN - 0 (Blood Glucose) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Insulin) RN - 0 (Triglycerides) RN - 7171WSG8A2 (BDNF protein, human) RN - 9007-41-4 (C-Reactive Protein) RN - 97C5T2UQ7J (Cholesterol) SB - IM MH - Adipokines/blood MH - Adult MH - Blood Glucose/metabolism MH - Body Mass Index MH - Brain-Derived Neurotrophic Factor/*genetics MH - C-Reactive Protein/metabolism MH - Cardiovascular Diseases/blood/*genetics MH - Cholesterol/blood MH - Cross-Sectional Studies MH - Diabetes Mellitus, Type 2/blood/*epidemiology/*genetics MH - Diet MH - Female MH - Humans MH - Insulin/blood MH - Insulin Resistance MH - Middle Aged MH - Obesity/blood/*epidemiology/*genetics MH - Polymorphism, Single Nucleotide MH - Prevalence MH - Prospective Studies MH - Risk Factors MH - Triglycerides/blood MH - Waist Circumference MH - White People/genetics OTO - NOTNLM OT - Brain-derived neurotrophic factor OT - Cardiovascular risk factors OT - Diabetes mellitus type 2 OT - rs10767664 EDAT- 2017/06/09 06:00 MHDA- 2018/04/24 06:00 CRDT- 2017/06/09 06:00 PHST- 2017/01/24 00:00 [received] PHST- 2017/03/31 00:00 [accepted] PHST- 2017/06/09 06:00 [pubmed] PHST- 2018/04/24 06:00 [medline] PHST- 2017/06/09 06:00 [entrez] AID - 000474956 [pii] AID - 10.1159/000474956 [doi] PST - ppublish SO - Ann Nutr Metab. 2017;70(4):286-292. doi: 10.1159/000474956. Epub 2017 Jun 9.