PMID- 28595202
OWN - NLM
STAT- MEDLINE
DCOM- 20180319
LR  - 20181023
IS  - 1308-4488 (Electronic)
IS  - 1016-5169 (Linking)
VI  - 45
IP  - 4
DP  - 2017 Jun
TI  - Vitamin D is a predictor of ST segment resolution and infarct size following 
      thrombolysis in patients with acute ST elevation myocardial infarction.
PG  - 324-332
LID - 10.5543/tkda.2017.17737 [doi]
AB  - OBJECTIVE: Vitamin D (VitD) insufficiency is linked to various chronic 
      conditions, including cardiovascular disease. Aim of the present study was to 
      examine role of serum VitD in resolution of ST segment elevation (STR) in 
      response to thrombolytic therapy following acute ST elevation myocardial 
      infarction (STEMI). METHODS: VitD was measured prospectively in all consecutive 
      patients who were admitted with STEMI and received thrombolysis during the 
      calendar year of 2014. STR was defined as >/=50% decrease in initial magnitude of 
      STR 90 minutes after treatment. Multivariate binary logistic regression analysis 
      was performed to identify effect of confounding variables on STR. RESULTS: 
      Average age was 58+/-14 years in 227 patients (41 female and 186 male). Total of 
      24.7% of patients had sufficient VitD (>30 ng/mL), whereas 46.2% had VitD 
      insufficiency (10-30 ng/mL), and remaining 29.1% had VitD deficiency (<10 ng/mL). 
      Significant STR occurred in 57.3% of the patients. In a nonlinear pattern, serum 
      VitD concentration directly correlated with likelihood of STR (p=0.012). VitD 
      deficient patients had larger enzymatic infarct size compared with those with 
      sufficient VitD (p=0.026). In multivariate logistic regression analysis, while 
      diabetes doubled (p=0.033) and involvement of anterior wall created 2.7-fold 
      increase in probability of nonresolution (p=0.001), for every unit increase in 
      serum VitD, likelihood of STR increased by 2.1% (p=0.023). CONCLUSION: VitD 
      deficiency in patients with STEMI was associated with lower occurrence of STR and 
      larger enzymatic infarct size in response to thrombolytic therapy.
FAU - Separham, Ahmad
AU  - Separham A
FAU - Sohrabi, Bahram
AU  - Sohrabi B
FAU - Pourafkari, Leili
AU  - Pourafkari L
FAU - Sepasi, Nazli
AU  - Sepasi N
FAU - Ghaffari, Samad
AU  - Ghaffari S
FAU - Aslanabadi, Naser
AU  - Aslanabadi N
FAU - Nader, Nader D
AU  - Nader ND
AD  - Department of Anesthesiology, University at Buffalo, Buffalo, NY, US. 
      nadernd@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - Turkey
TA  - Turk Kardiyol Dern Ars
JT  - Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir
JID - 9426239
RN  - 0 (Biomarkers)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Electrocardiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - ROC Curve
MH  - *ST Elevation Myocardial Infarction/blood/epidemiology/therapy
MH  - *Thrombolytic Therapy
MH  - Vitamin D/*blood
EDAT- 2017/06/09 06:00
MHDA- 2018/03/20 06:00
CRDT- 2017/06/09 06:00
PHST- 2017/06/09 06:00 [entrez]
PHST- 2017/06/09 06:00 [pubmed]
PHST- 2018/03/20 06:00 [medline]
AID - 10.5543/tkda.2017.17737 [doi]
PST - ppublish
SO  - Turk Kardiyol Dern Ars. 2017 Jun;45(4):324-332. doi: 10.5543/tkda.2017.17737.