PMID- 28595673
OWN - NLM
STAT- MEDLINE
DCOM- 20181018
LR  - 20220414
IS  - 1469-2198 (Electronic)
IS  - 0954-5794 (Print)
IS  - 0954-5794 (Linking)
VI  - 30
IP  - 2
DP  - 2018 May
TI  - Neonatal DNA methylation and early-onset conduct problems: A genome-wide, 
      prospective study.
PG  - 383-397
LID - 10.1017/S095457941700092X [doi]
AB  - Early-onset conduct problems (CP) are a key predictor of adult criminality and 
      poor mental health. While previous studies suggest that both genetic and 
      environmental risks play an important role in the development of early-onset CP, 
      little is known about potential biological processes underlying these 
      associations. In this study, we examined prospective associations between DNA 
      methylation (cord blood at birth) and trajectories of CP (4-13 years), using data 
      drawn from the Avon Longitudinal Study of Parents and Children. Methylomic 
      variation at seven loci across the genome (false discovery rate < 0.05) 
      differentiated children who go on to develop early-onset (n = 174) versus low (n 
      = 86) CP, including sites in the vicinity of the monoglyceride lipase (MGLL) gene 
      (involved in endocannabinoid signaling and pain perception). Subthreshold 
      associations in the vicinity of three candidate genes for CP (monoamine oxidase A 
      [MAOA], brain-derived neurotrophic factor [BDNF], and FK506 binding protein 5 
      [FKBP5]) were also identified. Within the early-onset CP group, methylation 
      levels of the identified sites did not distinguish children who will go on to 
      persist versus desist in CP behavior over time. Overall, we found that several of 
      the identified sites correlated with prenatal exposures, and none were linked to 
      known genetic methylation quantitative trait loci. Findings contribute to a 
      better understanding of epigenetic patterns associated with early-onset CP.
FAU - Cecil, Charlotte A M
AU  - Cecil CAM
AD  - King's College London.
FAU - Walton, Esther
AU  - Walton E
AD  - University of Bristol.
FAU - Jaffee, Sara R
AU  - Jaffee SR
AD  - University of Pennsylvania.
FAU - O'Connor, Tom
AU  - O'Connor T
AD  - University of Rochester Medical Center.
FAU - Maughan, Barbara
AU  - Maughan B
AD  - King's College London.
FAU - Relton, Caroline L
AU  - Relton CL
AD  - University of Bristol.
FAU - Smith, Rebecca G
AU  - Smith RG
AD  - Exeter University.
FAU - McArdle, Wendy
AU  - McArdle W
AD  - University of Bristol.
FAU - Gaunt, Tom R
AU  - Gaunt TR
AD  - University of Bristol.
FAU - Ouellet-Morin, Isabelle
AU  - Ouellet-Morin I
AD  - University of Montreal.
FAU - Barker, Edward D
AU  - Barker ED
AD  - King's College London.
LA  - eng
GR  - MC_UU_00011/4/MRC_/Medical Research Council/United Kingdom
GR  - MC_UU_12013/2/MRC_/Medical Research Council/United Kingdom
GR  - 102215/WT_/Wellcome Trust/United Kingdom
GR  - MC_PC_15018/MRC_/Medical Research Council/United Kingdom
GR  - R01 HD068437/HD/NICHD NIH HHS/United States
GR  - MC_UU_12013/8/MRC_/Medical Research Council/United Kingdom
GR  - G9815508/MRC_/Medical Research Council/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 102215/2/13/2/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20170609
PL  - United States
TA  - Dev Psychopathol
JT  - Development and psychopathology
JID - 8910645
SB  - IM
MH  - Adolescent
MH  - Age of Onset
MH  - Child
MH  - Child, Preschool
MH  - Conduct Disorder/*genetics
MH  - DNA Methylation/*genetics
MH  - Epigenesis, Genetic/*genetics
MH  - Female
MH  - Fetal Blood/*metabolism
MH  - *Genome-Wide Association Study
MH  - Humans
MH  - Infant, Newborn
MH  - Longitudinal Studies
MH  - Male
PMC - PMC7612607
MID - EMS143877
EDAT- 2017/06/10 06:00
MHDA- 2018/10/20 06:00
PMCR- 2022/04/11
CRDT- 2017/06/10 06:00
PHST- 2017/06/10 06:00 [pubmed]
PHST- 2018/10/20 06:00 [medline]
PHST- 2017/06/10 06:00 [entrez]
PHST- 2022/04/11 00:00 [pmc-release]
AID - S095457941700092X [pii]
AID - 10.1017/S095457941700092X [doi]
PST - ppublish
SO  - Dev Psychopathol. 2018 May;30(2):383-397. doi: 10.1017/S095457941700092X. Epub 
      2017 Jun 9.