PMID- 28596485
OWN - NLM
STAT- MEDLINE
DCOM- 20180423
LR  - 20181113
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 29
DP  - 2017 Jul 18
TI  - Rumen-derived lipopolysaccharide provoked inflammatory injury in the liver of 
      dairy cows fed a high-concentrate diet.
PG  - 46769-46780
LID - 10.18632/oncotarget.18151 [doi]
AB  - Rumen-derived lipopolysaccharide (LPS) is translocated from the rumen into the 
      bloodstream when subacute ruminal acidosis (SARA) occurs following long-term 
      feeding with a high-concentrate (HC) diet in dairy cows. The objective of this 
      study was to investigate the mechanism of inflammatory responses in the liver 
      caused by HC diet feeding. We found that SARA was induced in dairy cows when 
      rumen pH below 5.6 lasted for at least 3 h/d with HC diet feeding. Also, the LPS 
      levels in the portal and hepatic veins were increased significantly and 
      hepatocytes were impaired as well as the liver function was inhibited during SARA 
      condition. Meanwhile, the mRNA expression of immune genes including TNF receptor 
      associated factor 6 (TRAF6), nuclear factor-kappa B (NF-kappaB), p38 
      mitogen-activated protein kinase (MAPK), extracellular regulated protein kinases 
      (ERK) MAPK, Interleukin-1 (IL-1) and serum amyloid A (SAA) in the liver were 
      significantly increased in SARA cows. Moreover, the phosphorylation level of 
      NF-kappaB p65 and p38 MAPK proteins in the liver and the concentration of Tumor 
      Necrosis Factor (TNF-alpha), Interleukin-1beta (IL-1beta) and Interleukin-6 (IL-6) in 
      peripheral blood were obviously increased under SARA condition. In conclusion, 
      the inflammatory injury in the liver caused by LPS that traveled from the 
      digestive tract to the liver through the portal vein after feeding with a HC 
      diet.
FAU - Guo, Junfei
AU  - Guo J
AD  - College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, P.R. 
      China.
FAU - Chang, Guangjun
AU  - Chang G
AD  - College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, P.R. 
      China.
FAU - Zhang, Kai
AU  - Zhang K
AD  - College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, P.R. 
      China.
FAU - Xu, Lei
AU  - Xu L
AD  - College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, P.R. 
      China.
FAU - Jin, Di
AU  - Jin D
AD  - College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, P.R. 
      China.
FAU - Bilal, Muhammad Shahid
AU  - Bilal MS
AD  - College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, P.R. 
      China.
FAU - Shen, Xiangzhen
AU  - Shen X
AD  - College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, P.R. 
      China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NF-kappa B)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - *Animal Feed
MH  - Animals
MH  - Biomarkers
MH  - Cattle
MH  - Cytokines/blood/metabolism
MH  - Gene Expression Regulation
MH  - Hepatitis, Animal/blood/*etiology/*metabolism/pathology
MH  - Hepatocytes/metabolism/pathology
MH  - Hydrogen-Ion Concentration
MH  - Inflammation Mediators/metabolism
MH  - Lipopolysaccharides/blood/*metabolism
MH  - Liver Function Tests
MH  - NF-kappa B/metabolism
MH  - Phosphorylation
MH  - RNA, Messenger/genetics/metabolism
MH  - Rumen/*metabolism
MH  - Signal Transduction
MH  - p38 Mitogen-Activated Protein Kinases/metabolism
PMC - PMC5564522
OTO - NOTNLM
OT  - Immune response
OT  - Immunity
OT  - Immunology and Microbiology Section
OT  - dairy cows
OT  - inflammatory injury
OT  - lipopolysaccharide
OT  - liver
OT  - subacute ruminal acidosis
COIS- CONFLICTS OF INTEREST The authors declare no conflicts of interest.
EDAT- 2017/06/10 06:00
MHDA- 2018/04/24 06:00
PMCR- 2017/07/18
CRDT- 2017/06/10 06:00
PHST- 2017/01/09 00:00 [received]
PHST- 2017/05/11 00:00 [accepted]
PHST- 2017/06/10 06:00 [pubmed]
PHST- 2018/04/24 06:00 [medline]
PHST- 2017/06/10 06:00 [entrez]
PHST- 2017/07/18 00:00 [pmc-release]
AID - 18151 [pii]
AID - 10.18632/oncotarget.18151 [doi]
PST - ppublish
SO  - Oncotarget. 2017 Jul 18;8(29):46769-46780. doi: 10.18632/oncotarget.18151.