PMID- 28598012
OWN - NLM
STAT- MEDLINE
DCOM- 20180508
LR  - 20180508
IS  - 1523-5378 (Electronic)
IS  - 1083-4389 (Linking)
VI  - 22
IP  - 5
DP  - 2017 Oct
TI  - Meta-analysis: Association of Helicobacter pylori infection with Parkinson's 
      diseases.
LID - 10.1111/hel.12398 [doi]
AB  - BACKGROUND: The results from observational studies on the relationship between 
      helicobacter pylori (H. pylori) infection and Parkinson's disease remain 
      controversial. A meta-analysis was conducted to evaluate the association between 
      helicobacter pylori infection and Parkinson's disease. METHODS: A comprehensive 
      literature search was performed on relevant studies published from January 1983 
      to January 2017 in PubMed, Web of Science and EMBASE databases. The fixed or 
      random effects model was used to pool the odds ratio with 95% confidence interval 
      from individual studies. Publication bias was estimated by Egger's test and the 
      funnel plot. RESULTS: Eight eligible studies involving 33 125 participants were 
      included in this meta-analysis. Compared with the no helicobacter pylori infected 
      person, the pooled odds ratio of Parkinson's disease in helicobacter pylori 
      infected person was 1.59 (95% confidence interval: 1.37-1.85). In subgroup 
      analyzes, the combined odds ratios were 1.96 (1.23-3.12) in Asia, 1.55 
      (1.32-1.82) in Europe, 1.59 (1.35-1.88) in case-control studies, 1.56 (1.01-2.39) 
      in cross-sectional studies, 1.56 (1.32-1.85) in studies with confounders 
      adjusted, and 1.71 (1.21-2.43) in studies with no confounder adjusted, 
      respectively. CONCLUSIONS: This meta-analysis indicated that H. pylori infection 
      might be associated with the risk of Parkinson's disease.
CI  - (c) 2017 John Wiley & Sons Ltd.
FAU - Shen, Xiaoli
AU  - Shen X
AUID- ORCID: 0000-0003-1643-5167
AD  - Department of Epidemiology and Health Statistics, Qingdao University Medical 
      College, Qingdao, China.
FAU - Yang, Huazhen
AU  - Yang H
AD  - Department of Epidemiology and Health Statistics, West China School of Public 
      Health, Sichuan University, Chengdu, China.
FAU - Wu, Yili
AU  - Wu Y
AD  - Department of Epidemiology and Health Statistics, Qingdao University Medical 
      College, Qingdao, China.
FAU - Zhang, Dongfeng
AU  - Zhang D
AD  - Department of Epidemiology and Health Statistics, Qingdao University Medical 
      College, Qingdao, China.
FAU - Jiang, Hong
AU  - Jiang H
AD  - Departments of Physiology, Qingdao University Medical College, Qingdao, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20170609
PL  - England
TA  - Helicobacter
JT  - Helicobacter
JID - 9605411
SB  - IM
MH  - Asia/epidemiology
MH  - Cross-Sectional Studies
MH  - Europe/epidemiology
MH  - Helicobacter Infections/*complications
MH  - Humans
MH  - Parkinson Disease/*epidemiology
MH  - Risk Assessment
OTO - NOTNLM
OT  - helicobacter pylori
OT  - Parkinson's disease
OT  - meta-analysis
EDAT- 2017/06/10 06:00
MHDA- 2018/05/09 06:00
CRDT- 2017/06/10 06:00
PHST- 2017/06/10 06:00 [pubmed]
PHST- 2018/05/09 06:00 [medline]
PHST- 2017/06/10 06:00 [entrez]
AID - 10.1111/hel.12398 [doi]
PST - ppublish
SO  - Helicobacter. 2017 Oct;22(5). doi: 10.1111/hel.12398. Epub 2017 Jun 9.